DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7627 and abcc6a

DIOPT Version :9

Sequence 1:NP_001245943.1 Gene:CG7627 / 34148 FlyBaseID:FBgn0032026 Length:1355 Species:Drosophila melanogaster
Sequence 2:XP_009300481.1 Gene:abcc6a / 566555 ZFINID:ZDB-GENE-050517-18 Length:1507 Species:Danio rerio


Alignment Length:1392 Identity:459/1392 - (32%)
Similarity:728/1392 - (52%) Gaps:165/1392 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 PREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTKGKPN 77
            |.:..:|:|...||:......||.:..|..:||:...:|..||.:.:.|...|..:..|.:.:.|
Zfish   205 PVQDASFLSKILFWWFSGLIFKGYRSPLQAEDLWSLREEDTSERIISDLEEEWTAKRTKLQQQEN 269

  Fly    78 -------------------------------LLRALLRVFGWYFALLGLVLFLLELGLRTLQPIF 111
                                           |||.|.|.||.||....|.|.:.::.:.:: |..
Zfish   270 HMSTSAALGSRLPDQAQLLRKIQKEQSSGFCLLRTLARSFGPYFLTGTLCLIVHDVFMFSV-PQV 333

  Fly   112 LLKLIAYYTHGSESIESAYYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRL 176
            |..|:.:.......:...|:||..:.|.|.|..:..|.|......||::::..:..::|||:|.:
Zfish   334 LSLLLGFMKDEDTPLWKGYFYATLMFLLSCLQSVFNHQYTYTCFTVGMRVKTAVMGLVYRKSLVM 398

  Fly   177 SKSALGDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLL 241
            :.||....|.|.:|||:|.|..:|....::.:.:|:.|:|.....:.:::.:|.:|:.|:|.::.
Zfish   399 NSSARRTCTVGEIVNLVSADTQKLMDFVVYFNAVWLAPIEVTLCLFFLWQHLGPSALAGIATVIF 463

  Fly   242 FIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIR 306
            ..||..::.::.|.|:.......|.||::||||::||:::|.||||..|...|...|:||:..::
Zfish   464 IFPLNGFIARKRSKLQEIQMKYMDGRVKLMNEILNGIKILKFYAWEKAFLEQVLGYREKELKTLK 528

  Fly   307 HVSYIRGILL------SFIIFLTRVSIFLSLVGYVLLG--TFLTPEVAFLITAYYNILRTTMTVF 363
            ....:..:.|      ||:|......:      |||:.  ..|..:..|:..|..|||:|.::. 
Zfish   529 KSQILYSVSLASFNSSSFLIAFAMFGV------YVLIDDKNVLDAQKIFVSMALINILKTPLSQ- 586

  Fly   364 FPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLG 428
            .|..:|...:.|||:||:.|::..||....:::           :|:..:|.|            
Zfish   587 LPFAMSTTMQALVSLKRLGKFLCQDELKPDNVA-----------RESFKSDVD------------ 628

  Fly   429 PPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAI 493
               ..|.:|...|            |..:.|. .|..::::|..|:::.:||..|||||||:.|:
Zfish   629 ---GVVFDNGTFS------------WSKDGPP-CLKRISVKVPCGSLVAVVGHVGSGKSSLLSAM 677

  Fly   494 LGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFK 558
            |||....||.:.|.||::|..|:.|:.:.:::.|||||:......|.:|::.|||..|.:.||..
Zfish   678 LGETEKRSGTVSVKGSIAYVPQQAWIQNASLQDNILFGREKKESWYQRVLEACALLPDLDNLPAG 742

  Fly   559 DKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCM--RGYLRERI 621
            |.|.:||:|.:||||||.|:||||||||:..:|||||||||||.||.:|:|.:.:  :|.||::.
Zfish   743 DATEIGEKGLNLSGGQKQRVSLARAVYRKGDVYLLDDPLSAVDAHVGQHIFNKVIGPKGILRDKT 807

  Fly   622 VILATHQLQFLQHADQIVIMDKGRVSAVGTY-ESLRESG--LDFASMLADPERDE-QSEERSRSR 682
            .:|.||.:.||..||.|:::..|.:|..|:| |.|..:|  .||....|:.||.| .||...|..
Zfish   808 RVLVTHGMSFLPQADLILVLVDGEISERGSYQELLNRNGAFADFIHTFANSERKECFSEALQRGS 872

  Fly   683 SGSYTHSHSD----QRRNSEQSLLS----------MADSCMDDLEAE--QANNQERQEAGQIGLR 731
            ..|...|.:|    .|..|::.|:.          :.||..|.:..:  :....::...|::.|.
Zfish   873 RKSVRLSVTDYMPFSRDLSQEQLIGGDTNSIAIEPLPDSDEDHIPEDLGKLTKVDKARIGRVKLE 937

  Fly   732 LYSKYFKAGGGFFAFFVMMGFCVLSQGLASL-GDYFLSYWVTKKGNVAYRADN---NDTTRSEEL 792
            :|.:||:..|  ....:.:.|....|..||| .:|:||.|          ||.   |.|..:.:|
Zfish   938 MYIEYFRTIG--LPLIISIVFLYAFQQAASLSNNYWLSLW----------ADQPVINGTQLNTDL 990

  Fly   793 EPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRA 857
            :      |...|....|:.:..:..||...|..::              ||..||..:...:..:
Zfish   991 K------LGVYGALGFAQGISIFGTTVAISLGCII--------------ASRHLHLDLLNNVLHS 1035

  Fly   858 AMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGI 922
            .|.||.:.|||.:||||:|::..:|.::|..:..::..|..|..:.|::.:..|...:  ::|.:
Zfish  1036 PMSFFESTPSGNLLNRFAKEIDAIDNMIPDGLKMMLSYFFKLTEVCIIVLMATPFAAV--IILPM 1098

  Fly   923 IFYQ--LRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSS 985
            :|..  :::||:.||..::|:|:::|||:|:||..::.|.|.||||..|.......::..|.:.:
Zfish  1099 VFLYGFIQSFYVATSCQLRRLESVSRSPIYTHLNETVQGASVIRAFNEQSRFIMGANHKVDHNQT 1163

  Fly   986 AFY-MFISTSRAFGYWLDCFCV-----IYIAIITLSFFIFPPANGGDVGLAITQAMGMTGMVQWG 1044
            |:: .||:|.     ||.....     |.:|...||.......:.|.||||::.::.:||.:.|.
Zfish  1164 AYFPRFIATR-----WLGVNLEFLGNGIVLAASILSVMAKGTLSPGMVGLAVSHSLQVTGFLSWI 1223

  Fly  1045 MRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENV 1109
            :|...::||.:.:||||.||.|...|.|........|| |||:.|.|.|.:..|:|...  .|..
Zfish  1224 VRSWTDVENNIVSVERVKEYADTPKEAAWSIEGSSLPP-SWPQTGTIEFQDYGLQYRKG--LELA 1285

  Fly  1110 LKSLSFVIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVLIDKRDTSEMGLHDLRSKISIIP 1173
            ||.:|..|..:||:|||||||||||||...:|| |....|.:.||..:.:|:|||||||:|:|||
Zfish  1286 LKGISVHIHEREKIGIVGRTGAGKSSLALGIFRILEAAKGEIYIDGINIAEIGLHDLRSRITIIP 1350

  Fly  1174 QEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVC 1238
            |:||||||::|.|||||:.|||:::|.:||...||..|::||..|..:.:|||.|.|:|||||||
Zfish  1351 QDPVLFSGSLRMNLDPFNAYSDEEVWNALELAHLKNFVSELPDKLNHECSEGGENLSLGQRQLVC 1415

  Fly  1239 LARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGR 1303
            ||||:||:.::||:|||||.:|.:||.|||:|||::|::|.||||||||:||||..||:|||.|.
Zfish  1416 LARALLRKTKVLVLDEATAALDLETDTLIQSTIRSQFEDCAVLTIAHRLNTIMDYTKVIVMDKGH 1480

  Fly  1304 AVEFGTPYELLTLADSKVFHGMVKQTG 1330
            .||..:|..|  :|....|:.|.::.|
Zfish  1481 VVEMDSPSNL--IAKRGQFYYMCREAG 1505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7627NP_001245943.1 CFTR_protein 12..1315 CDD:273530 455/1375 (33%)
ABC_membrane 107..360 CDD:294371 71/260 (27%)
ABCC_MRP_domain1 445..645 CDD:213217 85/201 (42%)
ABC_membrane 815..1014 CDD:294371 54/206 (26%)
ABCC_MRP_domain2 1089..1310 CDD:213211 124/221 (56%)
abcc6aXP_009300481.1 MRP_assoc_pro 5..1506 CDD:188098 459/1392 (33%)
ABC_membrane 317..584 CDD:279056 73/273 (27%)
ABCC_MRP_domain1 630..831 CDD:213217 88/213 (41%)
ABC_membrane 955..1218 CDD:279056 78/299 (26%)
ABCC_MRP_domain2 1267..1487 CDD:213211 124/221 (56%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170586072
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.660

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