DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and abcc8

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	XP_005170744.1	Gene:	abcc8 / 553281	ZFINID:	ZDB-GENE-050517-22	Length:	1594	Species:	Danio rerio

Alignment Length:	1443	Identity:	441/1443 - (30%)
Similarity:	729/1443 - (50%)	Gaps:	220/1443 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NFISAACFWYTMPTFI-KGRKRTLDTKDLYRALKEHKSETLGNKLCASWELE------------- 68
            |.:|.:.:|: |.||| ...:|.:|.|.:.|.....::.|...||..::|.:
Zfish   236 NLLSKSTYWW-MNTFITSAHRRPIDLKVIGRLPIAMRALTNYIKLRQAFEAQKGPQDTPPQGSKW 299

  Fly    69 ----LEKTKGKPNLLRALLRV------FGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYTHGS 123
                |.:..|||.:|....|.      |.....:.|:|..|.:.....|.|:..|.:  |:....
Zfish   300 IWAALRQAFGKPLILSITYRFMADLLGFAGPLCISGIVHHLSKENHTILPPVKHLGM--YFISSQ 362

  Fly   124 ESIESAYYYAAGVILCSALNVIIMHPYMLGTMHV----GLKMRVGMCSMIYRKALRL--SKSALG 182
            |.:.:.|..|  |:|..||  ::...::..:.:|    |:.:|..:.:.|:.|.:||  |..::|
Zfish   363 EFLANGYVLA--VLLFFAL--LLQRTFLQASYYVAIETGINLRGAIQTKIFNKIMRLCTSNLSMG 423

  Fly   183 DTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQA 247
            ..|.|.:.||::.|..:|.........|:..|::.:....|:|..:||:|:.|...:.|..|:|.
Zfish   424 GMTVGQICNLVAIDTNQLMWFFFLCPNLFAMPVQIIVGIILLYYLLGISALIGATIITLLAPVQY 488

  Fly   248 YLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIR 312
            ::..:.|..:..|...:.||::..||::.||:::|:||||..|...|...|.||:.:::
Zfish   489 FVATKLSDAQKSTLEYSSERLKKTNELLRGIKLLKLYAWEHIFCSNVEETRCKELTSLQ------ 547

  Fly   313 GILLSFIIFLTRVSIFLSL---VGYVLLGTF-----------LTPEVAFLITAYYNILRTTMTVF 363
                :|.:: |.:|||::.   :..||: ||           |:|.|||...:.::||.|.: ..
Zfish   548 ----AFALY-TSISIFMNTAIPIAAVLV-TFVAHVHLSDDADLSPAVAFASLSLFHILVTPL-FL 605

  Fly   364 FPQGISQMAETLVSIKRVQKYMQSDE---------------TN----------VMDMSVDLTEDF 403
            ....:....:.|||::::.::...||               ||          |::....:.||:
Zfish   606 LSSVVRSTVKALVSVQKLSEFFSCDEIGGEQEPRATVVPNSTNHNKYQALPLKVVNRKRPVREDW 670

  Fly   404 -----QGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSL 463
                 |...::.|.|.|||                        :..|.|:.....|...:.  :|
Zfish   671 NSFALQSEQEDEVLAVGDE------------------------DICIKITNGYFSWTEGTS--TL 709

  Fly   464 NGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGE-----------------------LP--AESGE 503
            :.||:::..|.:..|||:.|.|||||:.|.|||                       ||  |..|:
Zfish   710 SNVNIKIPFGQLTMIVGQVGCGKSSLLLAALGEMQKISGTVIWNRMPTLDAEGNESLPDAAAEGD 774

  Fly   504 IKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGA 568
            |:..|:::||||:|||.:.|:.:||.|..|:.::||..|::.|:|:.|.::||..|:||:||||.
Zfish   775 IRKRGAVAYASQKPWLLNTTLAENITFEMPLIKQRYRAVIEACSLQPDIDILPQGDQTIIGERGI 839

  Fly   569 SLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRE--RIVILATHQLQF 631
            .|||||:.|||:|||:|:.|::..||||.||:|.|::.||.::.:...|||  |.|::.||:||:
Zfish   840 ILSGGQRQRISVARALYQTTNVVFLDDPFSALDIHLSDHLMQEGILKLLREEKRTVVIVTHKLQY 904

  Fly   632 LQHADQIVIMDKGRVSAVGTYESLRESGLDFASMLADPERDEQSEERSRSRSGSYTHSHSD---- 692
            |.|||.|:.|..|.:...||.:.:::|         .||..||.:.....:...:.....|
Zfish   905 LPHADWIIAMKDGSIQTEGTLKDIQKS---------QPELFEQWKTLMHRQDKEFEKETVDENMT 960

  Fly   693 --QRRN------SEQSLLSMADSCMDDLEAEQANN--QERQEAGQIGLRLYSKYFKAGGGFFAFF 747
              :|:|      |.::|.:..|...:.||::..:|  |..:....|..|....|..:.|......
Zfish   961 VLERKNLRRAMYSREALKTEEDEEEESLESDDDDNLSQVMRHRATIPWRSCGTYLSSAGLLLLLL 1025

  Fly   748 VMMGFCVLSQGLASLGDYFLSYWVTK--KGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAE 810
            :::. .:|...|....||:|::|.:|  ...:...|.|             .:.::|||.:..:.
Zfish  1026 LLLS-QLLKHSLLVAIDYWLAHWTSKVITAKIDAAAHN-------------CSLVQDIGFTHSSY 1076

  Fly   811 MLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFS 875
            :|   :|:::..|.|::.:|.|.......::.:..||:::...|..|.|..|.|.|.|.||||||
Zfish  1077 LL---VFSLLCCLGIVLCLATSVAVEWTGLRVAKELHHNLLSNIILAPMRLFETTPLGSILNRFS 1138

  Fly   876 KDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKR 940
            .|...:|:.:||.:..:.:..|.....:.||:.|.|:|||....|.|..|.::.::...|:|:::
Zfish  1139 SDTNTIDQHIPATLECLSRSTLLCVSALGVISYVTPVFLIVLAPLTIACYFIQKYFRVASKDLQQ 1203

  Fly   941 MEAITRSPVYSHLAASLTGLSTIRAFG-----AQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYW 1000
            :|..|:.|:.||.:.::.||:|||||.     .||:|:     :.|.::.|.....:.:|    |
Zfish  1204 LEDSTQLPLLSHFSETVEGLTTIRAFRYEPRFRQRLLQ-----FTDANNMASLFLTAANR----W 1259

  Fly  1001 LDC------FCVIYI-AIITLSFFIFPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAV 1058
            |:.      .|::.| |:.:::..::...:.|.|||.:|.|:.::..:.|.:|..|::|..:.||
Zfish  1260 LEVRMEYIGACIVLIAAVASITNSLYSHLSTGLVGLGLTYALMVSNYLNWMVRNLADMEVQLGAV 1324

  Fly  1059 ERVVEYEDIEP---EGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPK 1120
            :|:......||   ||.|.|   .:.|:.||:||:|....||:||  |...:.|||.::..|||.
Zfish  1325 KRIKALLRTEPENYEGLLSA---SQVPEGWPQQGEIQIQNLSVRY--DSTLKPVLKHVNAHIKPG 1384

  Fly  1121 EKVGIVGRTGAGKSSLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMR 1184
            :|:||.||||:||||...|.||: ...:|.::||..|.:::.|..|||:.|||.|:|.|||||:|
Zfish  1385 QKLGICGRTGSGKSSFSLAFFRMVDTFEGRIIIDDIDIAKLPLQTLRSRFSIIQQDPFLFSGTIR 1449

  Fly  1185 YNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRI 1249
            :||||..:.:|..||.:||..:||.||..||.||.:.|||||.|||.|||||.|||||.:|::.|
Zfish  1450 FNLDPEMKATDSMLWEALEIAQLKPVVKTLPGGLDAIITEGGENFSQGQRQLFCLARAFVRKSSI 1514

  Fly  1250 LVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELL 1314
            |:||||||::|..|:.::|..:...|.:.||:|||||:|||:::|.|:||..|..:||..|..||
Zfish  1515 LIMDEATASIDMATESILQKVVMTAFADRTVVTIAHRVHTILNADLVIVMKRGVILEFDKPEVLL 1579

  Fly  1315 TLADSKVFHGMVK 1327
            ...|| ||...|:
Zfish  1580 DQEDS-VFASFVR 1591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	435/1429 (30%)
		ABC_membrane	107..360	CDD:294371	72/272 (26%)
		ABCC_MRP_domain1	445..645	CDD:213217	91/226 (40%)
		ABC_membrane	815..1014	CDD:294371	60/210 (29%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	111/221 (50%)
abcc8	XP_005170744.1	MRP_assoc_pro	39..1591	CDD:188098	440/1441 (31%)
		ABC_membrane	<388..603	CDD:294371	61/226 (27%)
		P-loop_NTPase	693..918	CDD:304359	91/226 (40%)
		ABC_membrane	1038..1307	CDD:279056	77/293 (26%)
		P-loop_NTPase	1355..1594	CDD:304359	119/240 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586049
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.650