DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and l(2)03659

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster

Alignment Length:	1348	Identity:	855/1348 - (63%)
Similarity:	1042/1348 - (77%)	Gaps:	55/1348 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QSLKTADLPENPREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWE 66
            |:.|...||||||...||||:.|||||:|.|.||.::|||:.||||.|:|.||:.|||:||||||
  Fly    79 QNEKEKVLPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWE 143

  Fly    67 LELEKTKGKPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYTHGSESIESAYY 131
            .||:.....|:|:|||||||||.....||.:|::||||||||||||:|||:|::...::..:.:|
  Fly   144 RELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLISYFSGEPDAANAGFY 208

  Fly   132 YAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSND 196
            ||...|:.|||.|:|:.|...|..||..||||.|.|||:||||||:|.||||||:||||||:|||
  Fly   209 YAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISND 273

  Fly   197 VGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTA 261
            :.|||.|...|||||||||:.|.||||||:||||:|||||.|||||:|:|.|||.|||.::|:.|
  Fly   274 IPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAA 338

  Fly   262 LRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFLTRVS 326
            .|||.|:||:|||||.|||:||||||.|||.||..||:||:|.||...||||...:..|.|:||:
  Fly   339 ERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVA 403

  Fly   327 IFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETN 391
            |||||||||:||...|||:||:||||||:|...|:::.|..|.|.|:.|.||:||:::|||:|..
  Fly   404 IFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELG 468

  Fly   392 VMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDV 456
            ..|.|       :|.:::||..:              ||  :.|..|.|.::.|||..|.||||.
  Fly   469 SSDKS-------EGPSKDTVPGN--------------PP--SNNNEADLLKSAISIRDLKAKWDP 510

  Fly   457 NSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLFS 521
            |||||:|:|:||.::||:::.::|.||||||||||||||||.|.||:::||||:||.|||.||||
  Fly   511 NSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFS 575

  Fly   522 GTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYR 586
            ||||||||||||||.:||.:|||||||||||:|||.:|.||||||||:|||||||||||||:|||
  Fly   576 GTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYR 640

  Fly   587 ETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGT 651
            :.|||||||||||||..||||||:||:||:||...|:|.|||.|||.|.|||||:..|::.|:|.
  Fly   641 KASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGD 705

  Fly   652 YESLRESGL--DFASMLADPERDEQSEERSRSRSGSYTHSHSDQRRNSEQSLLSMADSCMDDLEA 714
            ||||.::||  ...|:....:...:.:|.....|....:..:..:.||||::...:..
  Fly   706 YESLLKTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSG------- 763

  Fly   715 EQANNQERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAY 779
              ..:.||||:|.|.|.||.|||:||||..||.||:...||:|...:.|||||:|||.|:...|.
  Fly   764 --KEHVERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAG 826

  Fly   780 RADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASI 844
            ..:..|                     ::::.:|.|.:|:|.:|::::.::.|||.||:|.||||
  Fly   827 HGEMED---------------------MESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASI 870

  Fly   845 RLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVV 909
            ||||::|..:|||.|:||:.|..|.|||||:|||.||||:||.|::||:||.|.||||:||||.|
  Fly   871 RLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANV 935

  Fly   910 NPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEA 974
            |||.|:||::|.:|||.||..|||||||:||:|||.||||||||||||.||:||||..||||||.
  Fly   936 NPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEK 1000

  Fly   975 EFDNYQDMHSSAFYMFISTSRAFGYWLDCFCVIYIAIITLSFFIFPPANGGDVGLAITQAMGMTG 1039
            |||:|||.|||||:|:||||:||||.::|.|||||:|||||||.|||.||.||||.||||||:..
  Fly  1001 EFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIITLSFFAFPPGNGADVGLVITQAMGLID 1065

  Fly  1040 MVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDP 1104
            |||||:||:|||||||||||||||||.|||||.||||.||||||:|||||:|:|.||:|||||:.
  Fly  1066 MVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNA 1130

  Fly  1105 KSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSVLIDKRDTSEMGLHDLRSKI 1169
            |:|||||||||||:|:|||||||||||||||||||||||||.|||||||.|||.:|||||||.:|
  Fly  1131 KAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRLSYTDGSVLIDTRDTRQMGLHDLRRQI 1195

  Fly  1170 SIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQR 1234
            ||||||||||||||||||||||||||:|||..||||||||||:|||.||.|||:|||||||||||
  Fly  1196 SIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQR 1260

  Fly  1235 QLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVM 1299
            ||||||||||||||||||||||||||||||||||.|||:||::|||||||||||||:|||||:||
  Fly  1261 QLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVM 1325

  Fly  1300 DAGRAVEFGTPYELLTLADSKVFHGMVKQTGHATYESLLKIAQKAFEN 1347
            ||||.||||:||||:|.:||||||.:|.|:|.|:||.||||||:.||:
  Fly  1326 DAGRVVEFGSPYELMTKSDSKVFHNLVNQSGRASYEGLLKIAQETFES 1373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	829/1304 (64%)
		ABC_membrane	107..360	CDD:294371	160/252 (63%)
		ABCC_MRP_domain1	445..645	CDD:213217	146/199 (73%)
		ABC_membrane	815..1014	CDD:294371	132/198 (67%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	191/220 (87%)
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	830/1306 (64%)
		ABC_membrane	171..437	CDD:294371	169/265 (64%)
		ABCC_MRP_domain1	499..699	CDD:213217	146/199 (73%)
		ABC_membrane	799..1045	CDD:294371	152/266 (57%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	191/220 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440870
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I210
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm26173
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
	13	12.810