DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and ABCC1

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	XP_016878726.1	Gene:	ABCC1 / 4363	HGNCID:	51	Length:	1549	Species:	Homo sapiens

Alignment Length:	1436	Identity:	472/1436 - (32%)
Similarity:	755/1436 - (52%)	Gaps:	233/1436 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTKGK-- 75
            |....:|:|...||:.....::|.::.|:..||:...||..||.:...|..:|:.|..||:.:
Human   227 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 291

  Fly    76 -------------------------------------PNLLRALLRVFGWYFALLGLVLFLLELG 103
                                                 |:|.:.|.:.||.|        ||:...
Human   292 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY--------FLMSFF 348

  Fly   104 LRTLQPIF------LLKLIAYYTHGSESIE-SAYYYAAGVILCSALNVIIMHPYMLGTMHV---- 157
            .:.:..:.      :|||:..:.:.:::.: ..|:|...:.:.:.|..:::|.|    .|:
Human   349 FKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY----FHICFVS 409

  Fly   158 GLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVGR-LDLATIFVHYLWVGPLETLFIT 221
            |::::..:...:|||||.::.||...:|.|.:|||||.|..| :|||| :::.:|..||:.:...
Human   410 GMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLAT-YINMIWSAPLQVILAL 473

  Fly   222 YLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAW 286
            ||::..:|.:.:.|||.|:|.:|:.|.:..:|...::......|.|:::||||::||:|:|:|||
Human   474 YLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAW 538

  Fly   287 ELPFEHMVAFARKKEINAIRHVSYIRG------ILLSFIIFLTRVSIFLSLVGYVLLGTFLTPEV 345
            ||.|:..|...|::|:..::..:|:..      :...|::.|...::::::..    ...|..:.
Human   539 ELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDE----NNILDAQT 599

  Fly   346 AFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQET 410
            ||:..|.:||||..:.: .|..||.:.:..||:||::.::..:|.....:.....:|..|:|..|
Human   600 AFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSIT 663

  Fly   411 VHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTM 475
            |                        .||..:            |..:.|. :|||:...:..|.:
Human   664 V------------------------RNATFT------------WARSDPP-TLNGITFSIPEGAL 691

  Fly   476 LGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYA 540
            :.:||:.|.|||||:.|:|.|:....|.:.:.||::|..|:.|:.:.::|:|||||..::...|.
Human   692 VAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYR 756

  Fly   541 KVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVA 605
            .|::.|||..|.|:||..|:|.:||:|.:||||||.|:|||||||....|||.||||||||.||.
Human   757 SVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVG 821

  Fly   606 RHLFEQCM--RGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLDFASML-- 666
            :|:||..:  :|.|:.:..||.||.:.:|...|.|::|..|::|.:|:|:.|......||..|
Human   822 KHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRT 886

  Fly   667 -ADPERDEQSEER-----------------------------SRSRSGSYTHSHSDQRRNSEQSL 701
             |..|:::.:||.                             .|..|.|.::|....|.::..:.
Human   887 YASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAE 951

  Fly   702 LSMADSCMDD----LEAEQANNQERQEAGQIGLRLYSKYFKAGGGFFAFF-VMMGFCVLSQGLAS 761
            |..|::..::    :||::|      :.||:.|.:|..|.||.|.|.:|. :.:..|.....|||
Human   952 LQKAEAKKEETWKLMEADKA------QTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALAS 1010

  Fly   762 LGDYFLSYWVTKKGNVAYRADN---NDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVL 823
              :|:||.|          .|:   |.|  .|..:.|||.: ..:|:|
Human  1011 --NYWLSLW----------TDDPIVNGT--QEHTKVRLSVY-GALGIS----------------- 1043

  Fly   824 TILVTVARSFLFFNLAMKASIR-------LHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQV 881
                   :....|..:|..||.       ||..:...|.|:.|.||...|||.::|||||::..|
Human  1044 -------QGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTV 1101

  Fly   882 DEILPAVMMDVIQIFLA----LAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRME 942
            |.::|    :||::|:.    :.|..|||.:..|:..|....||:|::.::.||:.:||.:||:|
Human  1102 DSMIP----EVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLE 1162

  Fly   943 AITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCF--C 1005
            :::|||||||...:|.|:|.||||..|.....:.|...|.:..|:|..|..:|.....|:|.  |
Human  1163 SVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNC 1227

  Fly  1006 VIYIAIITLSFFIFP--PANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIE 1068
            ::..|.:   |.:..  ..:.|.|||:::.::.:|..:.|.:|.|:|:|..:.||||:.||.:.|
Human  1228 IVLFAAL---FAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETE 1289

  Fly  1069 PEGALEAP---ADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTG 1130
            .    |||   .:..||.|||:.|::.|....|||..|  .:.||:.::..|...||||||||||
Human  1290 K----EAPWQIQETAPPSSWPQVGRVEFRNYCLRYRED--LDFVLRHINVTINGGEKVGIVGRTG 1348

  Fly  1131 AGKSSLINALFRLSYN-DGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYS 1194
            ||||||...|||::.: :|.::||..:.:::||||||.||:||||:||||||::|.|||||.:||
Human  1349 AGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYS 1413

  Fly  1195 DDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANV 1259
            |:::|.|||...||:.|:.||..|..:..|||.|.|||||||||||||:||:.:|||:|||||.|
Human  1414 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAV 1478

  Fly  1260 DPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHG 1324
            |.:||.|||:|||.:|::||||||||||:||||..:|:|:|.|...|:|.|.:|  |....:|:.
Human  1479 DLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDL--LQQRGLFYS 1541

  Fly  1325 MVKQTG 1330
            |.|..|
Human  1542 MAKDAG 1547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	467/1419 (33%)
		ABC_membrane	107..360	CDD:294371	74/270 (27%)
		ABCC_MRP_domain1	445..645	CDD:213217	83/201 (41%)
		ABC_membrane	815..1014	CDD:294371	66/211 (31%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	126/221 (57%)
ABCC1	XP_016878726.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151518
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.660