DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and abcc2

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_956883.2	Gene:	abcc2 / 393561	ZFINID:	ZDB-GENE-040426-1523	Length:	1567	Species:	Danio rerio

Alignment Length:	1483	Identity:	497/1483 - (33%)
Similarity:	771/1483 - (51%)	Gaps:	249/1483 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QSLKTADLPENPREHCNFISAACF-WYTMPTFIKGRKRTLDTKDLY------------------- 46
            ::.|.|:  .||.....|:|...| |:....: ||.||.|..:|::
Zfish   199 EAKKVAE--TNPEAKATFLSRITFNWFNSMVW-KGFKRPLVQEDMWDLNKNDSTHFICQTFEDVM 260

  Fly    47 -RALKEHKSETLGNK-----------------------LCASWELELEKTKGKPN---------- 77
             :.||:.::.....|                       |....|.|.|..|.|..
Zfish   261 AKELKKARNNLQKKKSKKRKTVDAEGQNGLAKGVSQDVLVMETETEKESKKKKKKKQKDSDSDYP 325

  Fly    78 ---LLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYTHGSESIE-SAYYYAAGVIL 138
               |:..:::.|..  .||...||.|...|.:.....||||:..:|...:|.. :.|.||..::|
Zfish   326 QSWLVTTIVKSFKG--VLLESALFKLLQDLLSFASPQLLKLMIAFTQNKDSYAWTGYLYAVLLVL 388

  Fly   139 CSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVGRLDLA 203
            .:.:..:::..|......:|:|:|..:.:.:|:|||.:|..:..::|||.:|||||.|..|.:..
Zfish   389 VAFVQSVVLQQYFQRCFILGMKVRTAIMAAVYKKALVVSNDSRKESTAGEIVNLMSADAQRFNDV 453

  Fly   204 TIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTALRTDERV 268
            |.|:|.||..||:.......::.|:|.:.:.|:..|:|.:|:..:|..::...:::.....|.|:
Zfish   454 TNFIHLLWSCPLQIALSIAFLWIELGPSVLSGLLVMVLMVPINGWLATKSRQFQMQNMKFKDSRM 518

  Fly   269 RMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIF--------LTRV 325
            :::|::::||:::|.||||..||..|...|:||:..:|..:|:..:  |..||        |...
Zfish   519 KIVNDLLNGIKILKYYAWETSFEAQVQEIREKELKVMRKFAYLSSV--STFIFSCAPALVSLATF 581

  Fly   326 SIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDET 390
            ::|:|    |.....|..|.||...:.:||||..:.: .||.||.|.:|.||.||::|::..|:
Zfish   582 AVFVS----VSPDNILDAEKAFTSISLFNILRFPLAM-LPQLISIMVQTSVSKKRLEKFLSGDD- 640

  Fly   391 NVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWD 455
                  :|.|                                ||..::.:: |.:|::.....|:
Zfish   641 ------LDTT--------------------------------TVTHDSSIT-AAVSMTNGTYAWE 666

  Fly   456 VNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLF 520
             ...:..|..|:|.::||.::.:||..||||:||:.|:||||.:..|.|.:|||::|..|:.|:.
Zfish   667 -RDTEPVLKRVSLDIKPGRLVAVVGAVGSGKTSLVSALLGELHSIKGNININGSVAYVPQQAWIQ 730

  Fly   521 SGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVY 585
            :.|::.|||||..:|..||..|:|.|||..|.:|||.:|:|.:||:|.:||||||.|:|||||||
Zfish   731 NATLKDNILFGSSVDEERYQSVIKACALGPDLDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVY 795

  Fly   586 RETSIYLLDDPLSAVDTHVARHLFEQCM--RGYLRERIVILATHQLQFLQHADQIVIMDKGRVSA 648
            ....:|||||||||||:||.:||||:.:  .|.||::..||.||.:.||.:.|:||::..|.||.
Zfish   796 SSADVYLLDDPLSAVDSHVGKHLFEKVIGPNGLLRDKTRILITHGISFLPYVDEIVVLVHGVVSE 860

  Fly   649 VGTYESLRESGLDFASMLADPERDEQSEERSR--------------------------------- 680
            :|:|||||.|...|:..|....:||.:::..:
Zfish   861 IGSYESLRASKGAFSEFLETYGKDESNKDNDKKAAAAQTPVYEEIETLPEGLETQADGSPEDIVS 925

  Fly   681 ---SRSGSYTHSHSDQRRN------SEQSLLSMADSCMDDLEAEQANNQERQEAGQIGLRLYSKY 736
               .|..|..||....:||      ...||.:..|.  :|.:.::...:|..|.|::...:|.:|
Zfish   926 STLKRENSLRHSQRHSKRNGSVKVRKNSSLRAQKDP--EDKKGQRLIEKEMMETGRVKFSVYLQY 988

  Fly   737 FKAGG----GF-FAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRL 796
            ..|.|    || |.|:.:....|:.|.|      :||.|            .:|:.  |......
Zfish   989 LSAMGWWYVGFSFVFYFIQNVAVIGQNL------WLSDW------------TDDSI--EYFNQTY 1033

  Fly   797 STWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFF-------NLAMKASIRLHNSMFRGI 854
            ...:||..:.|...:                .:|:.||.|       :.::.||..||.|:...|
Zfish  1034 PNHIRDTRIGVFGAL----------------GLAQGFLVFFGTILLADGSISASRTLHTSLLTNI 1082

  Fly   855 TRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVV 919
            .:..|.||:|.|||||:|||:||:..|||::|......|...|.:.|.:.||.:..|:|....|.
Zfish  1083 LKVPMMFFDTTPSGRIVNRFAKDIFTVDEMIPMSFRSWILCLLGVLGTLFVICLATPIFTAVVVP 1147

  Fly   920 LGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHS 984
            :.:::|.::.||:.|||.::|:::::|||:|||...:::|||.|||:|.|.......::..|.:.
Zfish  1148 MAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDRFLKRNEHTIDQNL 1212

  Fly   985 SAFYMFISTSR-------AFGYWLDCFCVIYIAIITLSFFIFPPANGGDVGLAITQAMGMTGMVQ 1042
            .:.|.:|.::|       :.|..:..|..::..|...|.      |.|.|||:|:.|:.:|..:.
Zfish  1213 KSVYPWIVSNRWLAMRLESLGNLVVFFAALFAVISRDSL------NSGLVGLSISYALNVTQTLN 1271

  Fly  1043 WGMRQSAELENTMTAVERVVEYEDIEPEGALEAP--ADKKPPKSWPEQGKIVFDELSLRYTPDPK 1105
            |.:|.::|||..:.|||||.||.:|:.    |||  ...:||..||..|.|.|::..:||.|:
Zfish  1272 WLVRMTSELETNIVAVERVREYAEIQN----EAPWVTSVRPPDDWPSAGNIRFEDYKVRYRPE-- 1330

  Fly  1106 SENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKI 1169
            .|.||..::..|:..||:|||||||||||||.|.|||: ...||.:|||..|.:.:|||||||::
Zfish  1331 LELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDLRSRL 1395

  Fly  1170 SIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQR 1234
            :||||:|||||||:|.|||||..:||.::|..||...|||.|..||:||:.:::|||.|.|:|||
Zfish  1396 TIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLSLGQR 1460

  Fly  1235 QLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVM 1299
            ||:|||||:||::|||::|||||.||.:||.|||:|||.:|..||||||||||:||:||.:|:|:
Zfish  1461 QLLCLARALLRKSRILILDEATAAVDLETDDLIQSTIRREFSHCTVLTIAHRLNTILDSSRVMVL 1525

  Fly  1300 DAGRAVEFGTPYELLTLADSKVFHGMVKQTGHATYESLLKIAQKAFENRQNHS 1352
            |:|:.|||.:|.|||:            :.||  :.|:.:.|....|..|:.|
Zfish  1526 DSGKIVEFDSPNELLS------------KPGH--FSSMAEDAGIRREEEQSQS 1564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	487/1434 (34%)
		ABC_membrane	107..360	CDD:294371	76/261 (29%)
		ABCC_MRP_domain1	445..645	CDD:213217	94/201 (47%)
		ABC_membrane	815..1014	CDD:294371	64/212 (30%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	129/221 (58%)
abcc2	NP_956883.2	MRP_assoc_pro	10..1555	CDD:188098	494/1472 (34%)
		ABC_membrane	346..612	CDD:294371	80/271 (30%)
		ABCC_MRP_domain1	656..856	CDD:213217	94/200 (47%)
		ABC_membrane	1001..1270	CDD:279056	86/310 (28%)
		ABCC_MRP_domain2	1316..1536	CDD:213211	129/221 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586115
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.660