Protein Alignment CG7627 and ABCC6

DIOPT Version :9

• Sequence 1: NP_001245943.1
• Gene: CG7627 / 34148
• FlyBaseID: FBgn0032026
• Length: 1355
• Species: Drosophila melanogaster
• Sequence 2: XP_024306029.1
• Gene: ABCC6 / 368
• HGNCID: 57
• Length: 1515
• Species: Homo sapiens
• Alignment Length: 1414
• Identity: 425/1414 - (30%)
• Similarity: 689/1414 - (48%)
• Gaps: 199/1414 - (14%)

  Fly    10 PENPREH-------CNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWE- 66
            ||:|::.       ..|.|.|.||:......:|.:|.|..|||:...:|:.||.|.::|...|.
Human   206 PEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMR 270

  Fly    67 ------------------------------LELEKTKGKPNLLRALLRVFGWYFALLGLVLFLLE 101
                                          |..|.::.:| ||:|:.:||...| |||.:..::.
Human   271 NRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRP-LLKAIWQVFHSTF-LLGTLSLIIS 333

  Fly   102 LGLRTLQPIFLLKLIAYYTHGSESIESAYYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMC 166
            ...|...|..|...:.:...........|..|..:.|.:.|..:.....|.....:.:::|..:.
Human   334 DVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAIT 398

  Fly   167 SMIYRKALRLSKSALGDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYL-MYREIGI 230
            .::|||.|.||..:...:..|.||||:|.||.||..:.::::.||: ||..:.:.:: :::.:|.
Human   399 GLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWL-PLVWIVVCFVYLWQLLGP 462

  Fly   231 AAVFGVAFMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVA 295
            :|:..:|..|..:||..::.|:.:..:.....:.|.|.|:.:.|:...:.||.:.||..|...|.
Human   463 SALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVL 527

  Fly   296 FARKKEINAIRHVSYIRGILLSFIIFLTRVSIFL-SLVGY----VLLGTFLTPEVAFLITAYYNI 355
            ..|.:|:.|:|    ..|:|.|..:...:||.|| :||.:    ::....:..|.||:.....||
Human   528 GIRGQELGALR----TSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNI 588

  Fly   356 LRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERD 420
            |.... .|.|..|..:.:..||..|:..::..:|.:
Human   589 LNKAQ-AFLPFSIHSLVQARVSFDRLVTFLCLEEVD----------------------------- 623

  Fly   421 EAEDKLLGPPIATVNENAKLSEAG---ISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRT 482
                    |.:  |:.::..|.||   |:|......|...||. .|:.:||.|..|.:|.:||..
Human   624 --------PGV--VDSSSSGSAAGKDCITIHSATFAWSQESPP-CLHRINLTVPQGCLLAVVGPV 677

  Fly   483 GSGKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCA 547
            |:|||||:.|:||||....|.:.:.|:::|..||.|:.:.:|.:|:.|||.:|.....:|::.||
Human   678 GAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACA 742

  Fly   548 LERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQC 612
            |:.|.:..|....|.:||:|.:||||||.|:||||||||:.::|||||||:|:|.||.:|:|.|.
Human   743 LQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQV 807

  Fly   613 M--RGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESL--RESGLDFASMLADPERDE 673
            :  .|.|:....||.||.|..|..||.|:::..|.::.:|:|:.|  |:..|   ..|.|..|..
Human   808 IGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGAL---MCLLDQARQP 869

  Fly   674 QSEERSRSRSGSYTHSHSDQRRNS---------EQSLLSMADSCMDDLEAE---QANNQERQ--- 723
            .......:..|:.|   .|.|..|         |:|:.|:.:......||:   ..::.:|.
Human   870 GDRGEGETEPGTST---KDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWP 931

  Fly   724 ------EAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRAD 782
                  :.|::...::..|.:|.|.....:.:  |..|.|.:||   :...||
Human   932 AGKDSIQYGRVKATVHLAYLRAVGTPLCLYAL--FLFLCQQVAS---FCRGYW------------ 979

  Fly   783 NNDTTRSEELEPRLSTWLRD--IGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLA------ 839
                         ||.|..|  :|.......|...||.::..|..:      .||.::|
Human   980 -------------LSLWADDPAVGGQQTQAALRGGIFGLLGCLQAI------GLFASMAAVLLGG 1025

  Fly   840 MKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVI 904
            .:||..|...:...:.|:.:.||...|.|.:||||||:...||..:|..:..::.....|..:.:
Human  1026 ARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSL 1090

  Fly   905 VIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQ 969
            |:||..||..:..:.|.:::...::.|:.:|..::|:|:.:.|.|.||:|.:..|.:.:|||..|
Human  1091 VVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQ 1155

  Fly   970 RVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDC----------FCVIYIAIITLSFFIFPPANG 1024
            ....|:.:...|......:..:...|    ||..          |.....|:::.:..     :.
Human  1156 APFVAQNNARVDESQRISFPRLVADR----WLAANVELLGNGLVFAAATCAVLSKAHL-----SA 1211

  Fly  1025 GDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAP-ADKKPPKSWPEQ 1088
            |.||.:::.|:.:|..:||.:|...:|||::.:|||:.:|.....|.....| ...:||  ||:.
Human  1212 GLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPP--WPQG 1274

  Fly  1089 GKIVFDELSLRYTPD-PKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVL 1151
            |:|.|.:..|||.|: |.:   ::.:||.|...||||||||||||||||.:.|.|| ...:|.:.
Human  1275 GQIEFRDFGLRYRPELPLA---VQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIW 1336

  Fly  1152 IDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPS 1216
            ||....:.:|||.|||:||||||:|:||.|::|.|||...|:||:.:|.:||.|:||.:||.||.
Human  1337 IDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPG 1401

  Fly  1217 GLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVL 1281
            .||.|..:.|.:.||||:||:|||||:||:.:||::|||||.|||.|:..:|..:.:.|.:||||
Human  1402 QLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVL 1466

  Fly  1282 TIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTG 1330
            .|||||.::||..:|||||.|:..|.|:|.:|  ||...:|:.:.:::|
Human  1467 LIAHRLRSVMDCARVLVMDKGQVAESGSPAQL--LAQKGLFYRLAQESG 1513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	419/1395 (30%)
		ABC_membrane	107..360	CDD:294371	64/258 (25%)
		ABCC_MRP_domain1	445..645	CDD:213217	86/201 (43%)
		ABC_membrane	815..1014	CDD:294371	51/214 (24%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	115/222 (52%)
ABCC6	XP_024306029.1	SunT	14..1514	CDD:331423	425/1414 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151601
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650