DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and CG31792

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster

Alignment Length:	1358	Identity:	925/1358 - (68%)
Similarity:	1094/1358 - (80%)	Gaps:	44/1358 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSLKTADLPENPREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASW 65
            |||.|..||||||||..|..||..||||:||||||:|.||..||||||||||::|:||||||:||
  Fly     1 MQSFKNEDLPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSW 65

  Fly    66 ELELEKTKGKPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYTHGSESIES-A 129
            ..|||..|...:|||.|.||||.||..||||||.||: :.|:||:||:|||:.:::.|.:... |
  Fly    66 ANELETNKKNASLLRVLFRVFGRYFVFLGLVLFCLEV-ILTVQPMFLMKLISSFSNPSPTSNGVA 129

  Fly   130 YYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMS 194
            |.||.||||.|||.||:|:||.....|:|||:|||:.||||||.|||:|:.||:.:.||::||:|
  Fly   130 YAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLIS 194

  Fly   195 NDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLR 259
            ||:||:|....|.||||:.||:.|.:|||||:|||||||||:.|:|||||||.||||:.|.|||:
  Fly   195 NDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLK 259

  Fly   260 TALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFLTR 324
            ||:|:|:|:|:|.|||:|||||||||||||||.|||.||.||||:||||:|.:.::.||..|||.
  Fly   260 TAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSFNRFLTP 324

  Fly   325 VSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDE 389
            |||||||||:||:|.|||.|||||||||||::||.||.:|..|::|.||||||||||||.:.|.|
  Fly   325 VSIFLSLVGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGE 389

  Fly   390 TNVMDMSVDLTEDFQGSNQETVHADG-DEERDEAEDKLL--GPPIATVNENAKLSEAGISISGLM 451
            ....|              |.|.::| :|:..||.:|||  ..|:....:....||..:|||.|.
  Fly   390 VVAKD--------------ENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELK 440

  Fly   452 AKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQE 516
            |||..|||||:|:||||:|..|.::.|||.||||||||||||||||..|||||:|.|||||||||
  Fly   441 AKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQE 505

  Fly   517 PWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLA 581
            |||||||||||||||||||||||..||:||||||||||||.|||||:|:||||||||||||||||
  Fly   506 PWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLA 570

  Fly   582 RAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHADQIVIMDKGRV 646
            |:|||:.|||||||||||||:.|||.|||:|:||:||::||||.||||||||.|||||||:.|:|
  Fly   571 RSVYRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKV 635

  Fly   647 SAVGTYESLRESGLDFASMLADPERD-EQSEERSRSRSGSYTHSHSDQRRNSEQSLLSMADSCMD 710
            .||||||||.:|||||..:|.||..| |.:|:|||      |.|.:||||:|.:|:||.|:||.:
  Fly   636 KAVGTYESLHKSGLDFGIVLDDPVNDNEAAEDRSR------TSSITDQRRSSVKSVLSHAESCPE 694

  Fly   711 DLEAEQANNQERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKG 775
            |:..||..|.:||:.|:.||.:|..||:|||||.:|.|:|.|.|.|||||||||||||.||::..
  Fly   695 DVGEEQKINLQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNE 759

  Fly   776 NVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAM 840
            .:   ..:|.||.:::               .|.||...||:.:||||:|:||:.||||||||||
  Fly   760 KM---VAHNYTTDAKD---------------ADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAM 806

  Fly   841 KASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIV 905
            :|||:|||||||||:||:|||||.||:|.||||||||||||||:||.::|.|||.||...|.:||
  Fly   807 RASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIV 871

  Fly   906 IAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQR 970
            ||:||||||||.:..||:.|.||:||||||.||||:||.||||||||.||||.||||||||||..
  Fly   872 IAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGS 936

  Fly   971 VLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCFCVIYIAIITLSFFIFPPANGGDVGLAITQAM 1035
            :||||||.||||||||.||||||||||.||:|.|||::||:||||||||||::..||||||||||
  Fly   937 ILEAEFDGYQDMHSSASYMFISTSRAFAYWMDIFCVLFIAMITLSFFIFPPSSAADVGLAITQAM 1001

  Fly  1036 GMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRY 1100
            |:||.|||.:||||||||||.:|||::|||:|||||.|||.|||||.:||||||||.|.||||||
  Fly  1002 GLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRY 1066

  Fly  1101 TPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSVLIDKRDTSEMGLHDL 1165
            .|..|||:||||||||||||||||||||||||||||||||||||||||||.||.:||::||||||
  Fly  1067 EPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSVRIDDKDTNDMGLHDL 1131

  Fly  1166 RSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFS 1230
            |||||||||||||||||:|:|||||||||||:||.:||||:||:|||.:.:||::||||||:|||
  Fly  1132 RSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFS 1196

  Fly  1231 VGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDK 1295
            |||||||||||||||:||||||||||||||||||.|||.||||||:||||||:|||||||||||:
  Fly  1197 VGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDR 1261

  Fly  1296 VLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTGHATYESLLKIAQKAFENRQNHSL 1353
            ||||||||.|||||||||||..|:..|..:|||||.|||::||||:|:.||..:..||
  Fly  1262 VLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTGQATYDTLLKISQREFEKSEKPSL 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	896/1307 (69%)
		ABC_membrane	107..360	CDD:294371	163/253 (64%)
		ABCC_MRP_domain1	445..645	CDD:213217	159/199 (80%)
		ABC_membrane	815..1014	CDD:294371	148/198 (75%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	188/220 (85%)
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	896/1307 (69%)
		ABC_membrane	94..360	CDD:294371	171/266 (64%)
		ABCC_MRP_domain1	434..634	CDD:213217	159/199 (80%)
		ABC_membrane	736..980	CDD:294371	171/261 (66%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	188/220 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440868
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I210
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm26173
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
	13	12.810