DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and Sur

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster

Alignment Length:	2052	Identity:	454/2052 - (22%)
Similarity:	732/2052 - (35%)	Gaps:	803/2052 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 FISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTKGKPNL----- 78
            |.|.:|||:..|....|.|..|:.:||.:...|..:.:..:.....:..:.:|:...|:|
  Fly   228 FYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSSPSLWYCYI 292

  Fly    79 --------LRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAY----YTHGSE------- 124
                    |..:|::.|..|||:|              |:.:.|::.|    |...||
  Fly   293 KNSWQMFALGGILKLAGDLFALIG--------------PLAIQKIVEYIEQLYAQASEPPAKSPG 343

  Fly   125 ------------------------SIESAYYYA-------------AGVILCSALNVIIMHPYML 152
                                    :|:....|:             |.::|.:|   |.......
  Fly   344 NEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAA---ITQGALSQ 405

  Fly   153 GTMHV----GLKMRVGMCSMIYRKALRL----------------SKSALGD---------TTAGH 188
            .:.|:    |::::..:..:||||:|.|                |.|:..|         .|..|
  Fly   406 ASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEH 470

  Fly   189 VVN----LMSNDVGRL------DLATI-----FVHYLWVGPLETLFITYLMYREIGIAAVFG-VA 237
            |.|    .:|:|:|.:      |...|     .:||.|..|.:...:.||:|..:||:||.| :|
  Fly   471 VDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIA 535

  Fly   238 FMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEI 302
            .:::..|||.::|...|......|..||||::.:::.:.||:|||:.||:..|...:..||:||:
  Fly   536 CIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKEL 600

  Fly   303 NAIRHVSYIRGILLSFIIFLTRVSIFLSLVGYVLLGTF----------LTPEVAFLITAYYNILR 357
                  .|:......:.:......|...|:.:|.||.:          |.....|...|.:..|
  Fly   601 ------KYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQL- 658

  Fly   358 TTMTVFFPQGISQMAETLVSIKRVQKYMQSDE--------------TNVMDMSVDLTEDFQGSN- 407
            |...:.||..:..:....||.:|::::::|.|              .:..|.|:|:.|..:.||
  Fly   659 TVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNM 723

  Fly   408 -QETVHADGDEERDEAEDKLLGPPIAT----VNENAKLS-------------------------- 441
             ..|..|:..........|...|.:||    :.:||:.|
  Fly   724 TMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLR 788

  Fly   442 ---------------------------------------------EAGISISGLMAKWDVNS--P 459
                                                         :..:||:..:..|...|  |
  Fly   789 NTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMP 853

  Fly   460 DYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEI--KVNGSMSYASQEPWLFSG 522
            ...|:...:.|..|.:..:||:.||||:||:.|:|.|:|..:|.:  ....::||.||:|||.:.
  Fly   854 VVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLND 918

  Fly   523 TVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRE 587
            |:|:|||||:....:||..|::.|||:.|.||:|..|.:|:||||.::||||:.||::|||:|..
  Fly   919 TIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSS 983

  Fly   588 TSIYLLDDPLSAVDTHVARHLFEQCMRGYLRE--RIVILATHQLQFLQHADQIVIMDKGRVSAVG 650
            .::.::||||:::|..|..|:|:.|:|..|::  |..||.|.||..::.|:.::.:..|||.|.|
  Fly   984 ANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACG 1048

  Fly   651 TY--------------------------------------------------------------- 652
            :|
  Fly  1049 SYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDAN 1113

  Fly   653 ----------------------------------------------------------------- 652

  Fly  1114 VACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPL 1178

  Fly   653 -----------------------------ESLRESGL---------------------------- 660
                                         .|.|.|||
  Fly  1179 PIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSS 1243

  Fly   661 ---------DFASMLADPERD-------------------------------EQSEERSRSRS-- 683
                     |.|:...:|...                               ::|||..||.:
  Fly  1244 YAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSS 1308

  Fly   684 ---------GSY----------------THSH---------------------------SDQRRN 696
                     ||:                .|.|                           :|..:|
  Fly  1309 ESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKN 1373

  Fly   697 ---------------SEQSLLSMADSC--MDDLE---------AEQANNQER------------- 722
                           |:::.::..|:|  ..|.|         |:|..:.||
  Fly  1374 ETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRE 1438

  Fly   723 ------------QEAGQIGLRLYSKYFKAGG--GFFAFFVMMGFCVLSQGLASLGDYFLSYW--- 770
                        ::.|:|...:|..|.:|.|  ....||:.   .::.|.|....|.:|..|
  Fly  1439 SMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFIT---ALIWQCLRVYTDIWLQQWSNV 1500

  Fly   771 ---VTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIF-------TVITVLTI 825
               |..||:|.......|    .|:                     ||.|       .|..::.:
  Fly  1501 HGRVASKGHVVLHPSEQD----HEV---------------------TYYFRMYAAISCVCIIMAL 1540

  Fly   826 LVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMM 890
            :.|.|..:...|    |...||:.:.:.|....::||...|.|||:||||.||..:|:.:.|...
  Fly  1541 VSTPAGQYAGCN----ARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQ 1601

  Fly   891 DVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAA 955
            .::|..|.....:::...:.|..|:.|:.:...:|.::.||..::|:::|:|..|.|||.|||:.
  Fly  1602 RLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSE 1666

  Fly   956 SLTGLSTIRAFGAQ-RVLEAEFDNYQDMHSSAFYMFISTS-RAFGYWLDCF--CVIYIAIIT--- 1013
            ::.|::|||||..| |..|..|...:  .::..|..::|| |..|..||..  |::::|.:|
  Fly  1667 TIQGVTTIRAFNQQTRFTEILFKRLE--ANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALT 1729

  Fly  1014 ---------LSFFIFPPANGGD---------------------VGLAITQAMGMTGMVQWGMRQS 1048
                     ......|.|:...                     |||||...:.:...:.|.::..
  Fly  1730 AASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLL 1794

  Fly  1049 AELENTMTAVERVVEYE---------------------DIEP----------------------- 1069
            |::|....:|||:..|.                     |.||
  Fly  1795 ADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVY 1859

  Fly  1070 -----------------------------------EGALEAPADK-------------------- 1079
                                               |...||.|||
  Fly  1860 PGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPA 1924

  Fly  1080 --------------------KPPK--------------------------SWPEQGKIVFDELSL 1098
                                .||:                          |||::|.|.||.:||
  Fly  1925 TAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSL 1989

  Fly  1099 RYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVLIDKRDTSEMGL 1162
            ||  :.:.:||:.:|:..|...:::||.||||:|||||..:||. |....|.:.||..|...:..
  Fly  1990 RY--EGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRP 2052

  Fly  1163 HDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVV-ADLPSGLQSKITEGG 1226
            .:||:::|||||:..||:.|:|.||||...:.|.:||..||..:|||.| ..||.||.:.|.:||
  Fly  2053 DELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGG 2117

  Fly  1227 TNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIM 1291
            .|.|.|.|||:||||||||.:..||:||||:.:|..|:..:.......|:..|::||||||.||:
  Fly  2118 LNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTIL 2182

  Fly  1292 DSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQ 1328
            |.|:::|:|.||.||.|.|.||..| :..||.|::::
  Fly  2183 DYDRLIVLDQGRIVEDGNPRELQQL-EGSVFRGLLEK 2218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	450/2037 (22%)
		ABC_membrane	107..360	CDD:294371	78/355 (22%)
		ABCC_MRP_domain1	445..645	CDD:213217	79/205 (39%)
		ABC_membrane	815..1014	CDD:294371	62/221 (28%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	102/222 (46%)
Sur	NP_001334732.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.160