DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and ABCB5

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_001157413.1	Gene:	ABCB5 / 340273	HGNCID:	46	Length:	1257	Species:	Homo sapiens

Alignment Length:	1273	Identity:	307/1273 - (24%)
Similarity:	518/1273 - (40%)	Gaps:	298/1273 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 ETLFITYLMYREIGIAA-VFGVAFMLLFIPLQAYLGKRT------SVL-------------RLRT 260
            |.:.:..|.|..||:|| :||...:.|:|...|...||.      |||             .|.|
Human   101 EDMTLLTLYYVGIGVAALIFGYIQISLWIITAARQTKRIRKQFFHSVLAQDIGWFDSCDIGELNT 165

  Fly   261 ALRTD---------ERVRMMNEIIS----GIQVIKMYAWELPF----------------EHMVAF 296
            .:..|         :::.::.:.:|    |:.|..:..|:|..                ..||..
Human   166 RMTDDIDKISDGIGDKIALLFQNMSTFSIGLAVGLVKGWKLTLVTLSTSPLIMASAAACSRMVIS 230

  Fly   297 ARKKEINAIRHVSYIRGILLSFI--IFLTRV------------------SIFLSLVGYVLLGTFL 341
            ...||::|......:...:||.|  :...|.                  .|..::...|.||.
Human   231 LTSKELSAYSKAGAVAEEVLSSIRTVIAFRAQEKELQRYTQNLKDAKDFGIKRTIASKVSLGA-- 293

  Fly   342 TPEVAFLITAYYNI-----------------LRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDE 389
               |.|.:...|.:                 :.|.:.|||....|...
Human   294 ---VYFFMNGTYGLAFWYGTSLILNGEPGYTIGTVLAVFFSVIHSSYC----------------- 338

  Fly   390 TNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGI---SISGLM 451
               :..:|...|.|..:.....|.....::..:.|              ..|.||.   ||.|.:
Human   339 ---IGAAVPHFETFAIARGAAFHIFQVIDKKPSID--------------NFSTAGYKPESIEGTV 386

  Fly   452 AKWDV--NSPDYS----LNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGS- 509
            ...:|  |.|...    |.|:|||::.|..:.:||..|||||:::|.:......:.|.|.|:.:
Human   387 EFKNVSFNYPSRPSIKILKGLNLRIKSGETVALVGLNGSGKSTVVQLLQRLYDPDDGFIMVDEND 451

  Fly   510 ------------MSYASQEPWLFSGTVRQNILFG------QPMDRRRYAKVVKKCALERDFEL-L 555
                        :...||||.||..|:..||.:|      :.|:|      ..:.|...||.: .
Human   452 IRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMER------AAREANAYDFIMEF 510

  Fly   556 PFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTH---VARHLFEQCMRGYL 617
            |.|..|:|||:||.:|||||.||::|||:.|...|.:||:..||:|:.   ..:...|:..:|
Human   511 PNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKG-- 573

  Fly   618 RERIVILATHQLQFLQHADQIVIMDKGRVSAVGTY-ESLRESGLDFASMLAD--PERDEQSEERS 679
              |..|:..|:|..::.||.||.:..|.::..|.: |.:.:.||.::.:::.  .:.|||.|
Human   574 --RTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQME--- 633

  Fly   680 RSRSGSYTHSHSDQRRNS--EQSLLSMADSCMDDLEAEQANNQERQEAGQIGLRLYSKYFKAGGG 742
                 |.|:| ::::.||  ..|:.|:....:|  :||::...:.....::.|....|..|....
Human   634 -----SMTYS-TERKTNSLPLHSVKSIKSDFID--KAEESTQSKEISLPEVSLLKILKLNKPEWP 690

  Fly   743 FFAFFVMMG--FCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGL 805
                ||::|  ..||:..:..:.....:..:|..||      |:.||                 |
Human   691 ----FVVLGTLASVLNGTVHPVFSIIFAKIITMFGN------NDKTT-----------------L 728

  Fly   806 SVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMK-ASIRLHNSMFRGITRAAMYFFN--TNPS 867
            ..|||:. :.||.::.|: ..|:.....||:..|.: .::||.:..|:.:....:.:|:  .|.:
Human   729 KHDAEIY-SMIFVILGVI-CFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENST 791

  Fly   868 GRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVV---NPLFLIPTV-----VLGIIF 924
            |.:....:.|:.|:.....: .:.|:.......|:.::|:.:   ...|||.::     |.|:|.
Human   792 GGLTTILAIDIAQIQGATGS-RIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIE 855

  Fly   925 YQLRT-FYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNY---QDMHSS 985
            ....| |..|..:::|....|.        ..:|..:.||.:...::..|..::..   |..::|
Human   856 TAAMTGFANKDKQELKHAGKIA--------TEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTS 912

  Fly   986 AFYMFISTSRAFGYWLDCFCVIYIAIITLSFFIFPPANGGDVGLAITQAMGMT--GM------VQ 1042
            .....|.:..||.:               :|..|..|.|...|..:.||..||  ||      :.
Human   913 KKAQIIGSCYAFSH---------------AFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIA 962

  Fly  1043 WGMRQSAELENTMTAVERVV---EYEDIEPEGA-LEAPADKKPP-KSWPEQGK--------IVFD 1094
            :|         .|...|.:|   ||...:...| |.|..:|||. .|..::||        :.|.
Human   963 YG---------AMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFR 1018

  Fly  1095 ELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYN--DGSVLIDKRDT 1157
            |:|..| |......:|:.||..|:..:.|..||.:|.|||:.:..|.|| |:  .|.||.|..|.
Human  1019 EVSFFY-PCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRL-YDPVQGQVLFDGVDA 1081

  Fly  1158 SEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVK-------LKEVVADLP 1215
            .|:.:..|||:|:|:|||||||:.::..|:    .|.|:.....|:|:|       :...:..||
Human  1082 KELNVQWLRSQIAIVPQEPVLFNCSIAENI----AYGDNSRVVPLDEIKEAANAANIHSFIEGLP 1142

  Fly  1216 SGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTV 1280
            ....:::...|...|.||:|.:.:|||:|::.:||::||||:.:|..::.::|..:.......|.
Human  1143 EKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTC 1207

  Fly  1281 LTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLAD 1318
            |.:.|||..|.::|.::|:..|:..|.||..|||...|
Human  1208 LVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRD 1245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	305/1268 (24%)
		ABC_membrane	107..360	CDD:294371	42/229 (18%)
		ABCC_MRP_domain1	445..645	CDD:213217	73/231 (32%)
		ABC_membrane	815..1014	CDD:294371	38/213 (18%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	76/237 (32%)
ABCB5	NP_001157413.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		PTZ00265	8..1251	CDD:240339	307/1273 (24%)
		ABC_membrane	52..333	CDD:279056	45/236 (19%)
		ABC_MTABC3_MDL1_MDL2	386..623	CDD:213216	75/246 (30%)
		ABC_membrane	696..962	CDD:279056	61/314 (19%)
		ABC_MTABC3_MDL1_MDL2	1016..1254	CDD:213216	79/236 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000