DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and wu:fb13g09

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	XP_009289330.1	Gene:	wu:fb13g09 / 336563	ZFINID:	ZDB-GENE-030131-8507	Length:	1393	Species:	Danio rerio

Alignment Length:	1386	Identity:	452/1386 - (32%)
Similarity:	728/1386 - (52%)	Gaps:	129/1386 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ENPREHCNFISAACFWYTMPTFIKGRKRT-LDTKDLYRALKEHKSETLGNKLCASWELELEKTKG 74
            ::|.::..|.|.....:..|...:..|.: |..:|::.......|||...:|...|..|| |.:|
Zfish    59 QHPVDNAGFFSFMTLQWLSPLAWRAHKDSCLKMEDVWGLSCHEASETNCQRLEWLWHEEL-KRRG 122

  Fly    75 KPNLLRALLRVFGWYFA----LLGLVLFLLELGLRTLQPIFLLKLIAYYTHGSESIESAYYYA-- 133
            |..  .:|.||| |.|.    |:.:...|:.:....:.|..|::.:..::..|| ::..|..|
Zfish   123 KDG--ASLSRVF-WRFCQTRMLVAIFSLLITMVAGFVGPALLIRALLEFSQCSE-VKLLYGLALV 183

  Fly   134 AGVILCSALNVIIMHPYMLGTM-----HVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLM 193
            ||:.|..     :...:.|..|     ....::|....:..::|.|||..:.  |.::|.:||:.
Zfish   184 AGIFLME-----LTRSWSLAFMWAINYRTAARLRGAALTFAFQKILRLRSTK--DVSSGELVNIC 241

  Fly   194 SNDVGRLDLATIFVHYLWVGPL-ETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLR 257
            ::|..||..|......|..||| ..|.:||..| .:|..|:.|.|..::|.|......:.|:..|
Zfish   242 ASDGQRLYEAVSVGCLLAGGPLVGMLGLTYTTY-FLGPTALVGSAIFIIFYPTMMLASRMTAYFR 305

  Fly   258 LRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFL 322
            .:....||.|||:||||:..::.||||.||.||.:.:...|.:|...:.....::.:.|.....:
Zfish   306 KKCVAVTDRRVRLMNEILGCMKFIKMYCWETPFANNIQKVRSEERRNLEWAGCVQSLTLGVAPVV 370

  Fly   323 TRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQS 387
            ..::...:...::.||..||...||.:.|.:|.:...:.| .|..:..::|..|::||.||....
Zfish   371 VVIASVCTFTLHMALGYDLTAAQAFTVVAVFNSMTFALKV-TPLAVRALSEGSVAVKRFQKLFMM 434

  Fly   388 DETNVMDMSVDLTED-------------------FQGSNQETVHADGDEERDEAEDKLLGPPIAT 433
            ::..::.:.   |||                   .|.....|....|..:|....:| |...|.|
Zfish   435 EDRELISVK---TEDPYNVVEFKDATLAWEKTCGSQTKKSRTQLKRGGMKRVLRREK-LSLYIIT 495

  Fly   434 VNENAKLSEAGISISGLMAKWDVNSPD--------------YSLNGVNLRVQPGTMLGIVGRTGS 484
            .....|:.|.  :...|:...:..||.              .:|:.::|.:|.|:::|:.|..||
Zfish   496 EENKGKIEEP--NAEHLLTHMEQESPQSTISSTQSIRPPLHKTLHRIDLCIQKGSLVGVCGGVGS 558

  Fly   485 GKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALE 549
            |||||:.|:||::....|.:.|||..:|.:|:.|:.:.::|:|||||:..:..:|..|::.|.|.
Zfish   559 GKSSLLSALLGQMTLLGGSVSVNGGFAYVAQQAWILNDSLRENILFGKKYNEEKYNAVLEACCLF 623

  Fly   550 RDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMR 614
            .|...||:.|.|.:|||||:|||||:.|:|||||:|.|..|.||||||||||..|...||...:|
Zfish   624 PDIIELPYGDMTEIGERGANLSGGQRQRVSLARALYSERPILLLDDPLSAVDARVGSRLFHSAIR 688

  Fly   615 GYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLDFASMLADPERDE------ 673
            ...:.:.||..|||||:|...|.:|:|..|:::..||:..|.|.|.|:|::....:::.
Zfish   689 PAAKGKTVIFVTHQLQYLPECDDVVLMKDGQIAEHGTHTQLMEKGRDYAALFNSVQQENLVRKNL 753

  Fly   674 QSEERSRSRSGSYT-HSHSDQRRNSEQSLLSMADSCMDDLEAEQANNQERQEAGQIGLRLYSKYF 737
            :::|::...|...| |..:..:.::|..            :.:|....|.:.:|.:...:|:.|.
Zfish   754 KNKEKAEKESSPQTLHVSNPPKPDTESK------------KTDQLMQAEEKGSGAVAWPVYAAYI 806

  Fly   738 KAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSE--ELEPRLSTWL 800
            ||.||..||.|.:...:.:.|..:..:::||||:.:....:.....|:|..|:  .|.|.:..:.
Zfish   807 KAAGGPLAFIVTILLFLFTTGSIAFSNWWLSYWIRQGSGNSSLLLGNETAESDSMRLNPHIQYYS 871

  Fly   801 RDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTN 865
            |...||:.|.:             .|.|: |..:|....::|:..||:.:|:.:..:.|.||:|.
Zfish   872 RVYVLSMGAAL-------------FLKTI-RGLVFVKCTVRAASVLHDKLFKTLLLSPMRFFDTT 922

  Fly   866 PSGRILNRFSKDMGQVDEIL---PAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQL 927
            |.|||||||||||.:||..|   ..:::..:.:.|...|   |:..|.|.||...:.||...:.:
Zfish   923 PLGRILNRFSKDMDEVDVRLAMQAEMLLQNVTLVLFCLG---VVGAVFPWFLFSIIPLGAFLFIV 984

  Fly   928 RTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEF-DNYQ---DMHSSAFY 988
            ........|::||:|.|::||..||:.:||.|||||.|:|.    .|:| ..||   |.:.:..:
Zfish   985 NRISRVLIRELKRLENISQSPFTSHITSSLQGLSTIYAYGR----GADFIHRYQALLDTNQACQF 1045

  Fly   989 MFISTSRAFGYWLDCFCVIYIAIITLSFFI----FPPANGGDVGLAITQAMGMTGMVQWGMRQSA 1049
            :|....|.....||...:..|..:.|...:    ..||.   .|||::.|:.:||:.|:.:|..:
Zfish  1046 LFSCAMRWLAVRLDLISISLITTVALLIVLMHGHISPAY---AGLALSYAVQLTGLFQFTVRLLS 1107

  Fly  1050 ELENTMTAVERVVEY-EDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPD-PKSENVLKS 1112
            |.|...|:|||:..| :::|.||..:.........|||.:|:|.|.::.:||... |.   |||:
Zfish  1108 ETEARFTSVERINHYIKNLESEGPRQITGCPTSSSSWPAEGQITFQDVEMRYRDGLPL---VLKN 1169

  Fly  1113 LSFVIKPKEKVGIVGRTGAGKSSLINALFRLS-YNDGSVLIDKRDTSEMGLHDLRSKISIIPQEP 1176
            |.|.|.|:|.:|||||||:|||||..|||||: .:.||::||..:.:.:||.|||||:|:|||||
Zfish  1170 LCFSILPEETIGIVGRTGSGKSSLGVALFRLAELSRGSIIIDGVNIAHIGLEDLRSKLSVIPQEP 1234

  Fly  1177 VLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLAR 1241
            |||.||:|.||||:|:|:|.::|.:||:..:|::|:.||:.|.|::|:.|.|||||:|||:|:||
Zfish  1235 VLFIGTVRSNLDPWDQYTDAQIWEALEKTHIKDMVSQLPNSLHSEVTDNGENFSVGERQLLCVAR 1299

  Fly  1242 AILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVE 1306
            |:||.::||::|||||.:|.:||.|||.|||:.|..||.|.|||||:|::..::::|:|.|:.:|
Zfish  1300 ALLRHSKILLLDEATAAIDTETDRLIQDTIRSSFSGCTTLVIAHRLNTVLGCNRIMVLDQGQILE 1364

  Fly  1307 FGTPYELLTLADSKVFHGMVK 1327
            |.||..|||..:|: ||.|::
Zfish  1365 FDTPSNLLTDENSR-FHAMME 1384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	446/1371 (33%)
		ABC_membrane	107..360	CDD:294371	68/260 (26%)
		ABCC_MRP_domain1	445..645	CDD:213217	85/213 (40%)
		ABC_membrane	815..1014	CDD:294371	64/205 (31%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	117/222 (53%)
wu:fb13g09	XP_009289330.1	SunT	61..1386	CDD:331423	452/1384 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585989
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.760