DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and abcc5

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_001182542.1	Gene:	abcc5 / 336147	ZFINID:	ZDB-GENE-050517-17	Length:	1426	Species:	Danio rerio

Alignment Length:	1401	Identity:	462/1401 - (32%)
Similarity:	741/1401 - (52%)	Gaps:	154/1401 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSLKTADLPENPREHCNFISAACF-WYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCAS 64
            ::.:::....::|.::....|...| |.|....:..:|..|..:|::...:....|....:|...
Zfish    83 LKPIRSTSKYQHPVDNAGLFSFMTFNWLTSLAVLAHKKGQLFLEDIWAVSQFESCEINRRRLAGL 147

  Fly    65 WELELEKTKGKPNLLRALLRVFGWYFALLGLVLFLLELGLRTL----QPIFLLKLIAYYTHGSE- 124
            ||.|: :::|....||.::    |:|....|:|.:|.|.:..|    .|.|::..:..||..||
Zfish   148 WEEEI-RSRGNDASLRRVV----WHFCRTRLLLSILCLMVTQLAGFSSPAFVVWRLLEYTQRSEP 207

  Fly   125 SIESAYYYAAGVI-----------LCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSK 178
            .:........|::           |..|||      |..||     ::|..:.:|.:.|.|||
Zfish   208 DLPYGLLLVLGLLATELIRSWSHALTWALN------YRTGT-----RLRGAILTMAFHKILRL-- 259

  Fly   179 SALGDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPL-ETLFITYLMYREIGIAAVFGVAFMLLF 242
            .:|.:.:.|.::|:.|.|..|:..|......|..||| ..|.:.|.:: .:|..::.|.|..:||
Zfish   260 RSLREKSMGELINMCSGDGQRMFEAAAVGSLLAGGPLVAVLGMAYNLF-VLGPTSLLGSAVFILF 323

  Fly   243 IPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRH 307
            .|...:..:.|:..|.:....||:||:.||||::.|:.||||||...|...|...|.:|...:..
Zfish   324 YPTMMFSSRLTAYFRRKGVAVTDQRVQKMNEILNYIKFIKMYAWVKAFSQAVRRIRDEERQILER 388

  Fly   308 VSYIRGILLS---FIIFLTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGIS 369
            ..|.:.|.:.   .::.:..|:.|.:   ::|||..||...||.:...:|.:...:.| .|..:.
Zfish   389 TGYFQSITVGVAPIVVVIASVATFST---HMLLGYDLTAAQAFTVVTVFNAMTFALKV-TPFSVK 449

  Fly   370 QMAETLVSIKRVQKYMQSDETNVM-------DMSVDLT----------EDFQGSNQETVHAD--G 415
            .::|..|:|.|.:..:...|..::       .::|:::          ...|.|.:.|.|..  |
Zfish   450 SLSEASVAIDRFKSLLLMAEVKMIRELPRNPSVAVEMSGASLAWETGGHSAQPSPRGTPHVGTRG 514

  Fly   416 DEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSP--------------DYSLNGV 466
            ..::....|.   |....:.|.....:....:||.||    :||              ..:|:.:
Zfish   515 CRKKRRQRDV---PKHHAILEEETHGQLLNDVSGEMA----SSPKDQTLHVPTISQRLQRTLHCI 572

  Fly   467 NLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFG 531
            :|.:|.|.::|:.|..||||:|||.||||::....|.:.|:|..:|.:|:.|:.:.:.|.|||||
Zfish   573 DLSIQKGKLVGVCGSVGSGKTSLISAILGQMTLLEGTVAVDGDFAYVAQQAWILNASFRDNILFG 637

  Fly   532 QPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDP 596
            :.|:..||..::..|.|..|..:||..|.|.:|||||:|||||:.|||||||:|....||:||||
Zfish   638 KEMEEERYQAILSACCLRPDLAMLPSGDLTEIGERGANLSGGQRQRISLARALYSNRGIYILDDP 702

  Fly   597 LSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLD 661
            |||:|.||..|:|...::..||.:.||..|||||:|...|.:::|..|.::..|::|.|.....|
Zfish   703 LSALDAHVGNHIFNNAIKKQLRGKTVIFVTHQLQYLVDCDDVIVMRDGSIAEQGSHEDLMNVNGD 767

  Fly   662 FASMLADPERDEQS-EERSRSRSGSYTHSHSDQRRNSEQSLLSMADSCMDDLEAEQANNQ----E 721
            :|:|..:.:..|.. .|....:|||......::         |.|.|...:....|.:.|    |
Zfish   768 YAAMFNNLQLGETPIIEVPNKKSGSSLKKPLEK---------SKAGSVKKEKSTTQGDGQLMQVE 823

  Fly   722 RQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTK-KGNVAYRADNND 785
            .:..|.:...:|..|.:|.||:..|..::...:|:.|..:..:::|.||:.: .||...:..|:.
Zfish   824 ERGKGSVPWAVYKVYIQALGGWPVFLFILALFILNVGSTAFSNWWLCYWIKQGSGNTTVQVGNSS 888

  Fly   786 TTRSEELEPRLSTWLRDIGLSVDAEMLDTY--IFTVITVLTILVTVARSFLFFNLAMKASIRLHN 848
            .         ||..:|      |..::..|  ::|:...:.:|:.:.|..:|....::||.|||:
Zfish   889 V---------LSESMR------DNPLMQHYAAVYTMSMGVMLLLKLLRGIVFVKGTLRASSRLHD 938

  Fly   849 SMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILP--AVM--MDVIQIFLALAGIVIVIAVV 909
            .:|:.|.|:.|.||:|.|:.||||||||||.:||..||  |.|  .:||.:...||    ||..|
Zfish   939 ELFQKILRSPMKFFDTTPTARILNRFSKDMDEVDTRLPFQAEMFTQNVILVLFCLA----VIGSV 999

  Fly   910 NPLFLI---PTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRV 971
            .|.||:   |.|:|..:.:.:...::   |::||::.:|:||..||:|:|:.||:|:.|:|.:..
Zfish  1000 FPWFLVAVGPLVLLFTVLHVVSRVFI---RELKRLDNVTQSPFLSHIASSIQGLTTVHAYGKEDE 1061

  Fly   972 LEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCFCVIYIAIITLSFFI----FPPANGGDVGLAIT 1032
            ....:....|.:.:.||:|....|.....||...|..|:|..|...:    .|||.   .||||:
Zfish  1062 FLHRYQELLDQNQAPFYLFSCAMRWLAVRLDVISVALISITALMIVLMHGQIPPAY---AGLAIS 1123

  Fly  1033 QAMGMTGMVQWGMRQSAELENTMTAVERVVEY-EDIEPEGALEAPA---DKKPPKSWPEQGKIVF 1093
            .|:.:||:.|:.:|.::|.|...|:|||:..| :.:    :|||||   :|.||..||::|:|||
Zfish  1124 YAVQLTGLFQFTVRLASETEARFTSVERIHHYIKSL----SLEAPARVKNKAPPSDWPQEGEIVF 1184

  Fly  1094 DELSLRYTPDPKSEN---VLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVLIDK 1154
            |:..::|     .:|   :||..||.::||||:|||||||:|||||...|:|| ....||:.||.
Zfish  1185 DQTEMKY-----RDNLPLILKKASFTVRPKEKIGIVGRTGSGKSSLGVVLYRLVEPCGGSIKIDG 1244

  Fly  1155 RDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQ 1219
            .:..::||.|:|||:|||||||||||||:|.|||||.:||:.::|.:||...:||.|:.||..|:
Zfish  1245 VNICDIGLADVRSKLSIIPQEPVLFSGTVRSNLDPFSQYSEAQIWDALERTHMKECVSQLPLKLE 1309

  Fly  1220 SKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIA 1284
            |::.|.|.|||||:|||:|:||.:||:.:||::|||||.:..:||.|||.||||.|::||.||||
Zfish  1310 SEVVENGENFSVGERQLLCVARVLLRQCKILILDEATAAMGTETDCLIQETIRNAFQDCTTLTIA 1374

  Fly  1285 HRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSK 1320
            ||:||::..|:::|::.|:.|||..|.:||...:|:
Zfish  1375 HRVHTVLSCDRIMVLNQGQVVEFDEPSKLLANENSR 1410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	460/1383 (33%)
		ABC_membrane	107..360	CDD:294371	73/272 (27%)
		ABCC_MRP_domain1	445..645	CDD:213217	89/213 (42%)
		ABC_membrane	815..1014	CDD:294371	72/207 (35%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	119/224 (53%)
abcc5	NP_001182542.1	intraplasmic N-terminal	1..59
		transmembrane domain 1	59..149		10/65 (15%)
		CFTR_protein	95..1419	CDD:273530	462/1389 (33%)
		ABC_membrane	177..441	CDD:294371	75/280 (27%)
		nucleotide binding domain 1	188..248		15/70 (21%)
		transmembrane domain 2	279..379		33/100 (33%)
		nucleotide binding domain 2	403..450		12/50 (24%)
		ABCC_MRP_domain1	552..751	CDD:213217	83/198 (42%)
		ABC_membrane	851..1132	CDD:294371	95/305 (31%)
		ABCC_MRP_domain2	1180..1400	CDD:213211	119/224 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585979
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.660