DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and Abcc12

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	XP_008770597.1	Gene:	Abcc12 / 291923	RGDID:	735100	Length:	1378	Species:	Rattus norvegicus

Alignment Length:	1415	Identity:	446/1415 - (31%)
Similarity:	728/1415 - (51%)	Gaps:	174/1415 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLKT-------ADLPENPREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNK 60
            ||||       |.|..||.:....:|.|.|.:..|..|:..|.|| |.|....|..:.|..:..|
  Rat    28 SLKTMIPMRPYARLAPNPVDDAGLLSFATFSWLTPVMIRSYKHTL-TVDTLPPLSPYDSSDVNAK 91

  Fly    61 -LCASWELELEKTKGKPNLLRALLRVFGWYF----ALLGLVLFLLELGLRTLQPIFLL-KLIAYY 119
             |...|:.|:|:...:    ||.|....|.|    .|:.:|..:|.:.:..|.|..|: :::.:.
  Rat    92 RLQILWDEEIERVGPE----RASLGRVVWKFQRTRVLMDVVANILCIIMAALGPTVLIHQILQHV 152

  Fly   120 THGSESIESAYYYAAGVILCSAL------NVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSK 178
            |:.|..     :....:.||.||      .|:.............::::|.:.::|::..  ||.
  Rat   153 TNISSG-----HIGISICLCLALFATEFTKVLFWALAWAINYRTAIRLKVALSTLIFKNL--LSF 210

  Fly   179 SALGDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFI 243
            ..|...:||.|:|::|:|...|..|.:|.......|:..:......:..:|..|:.|:...|:||
  Rat   211 KTLTHISAGEVLNVLSSDSYSLFEAALFCPLPATIPILMVVCAVYAFFILGSTALVGICVYLIFI 275

  Fly   244 PLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHV 308
            |:|.::.|..|..|......||:||:.|||.::.|::|||||||..|.:.:...||:|...:...
  Rat   276 PIQMFMAKLNSAFRRSAISVTDKRVQTMNEFLTCIKLIKMYAWEKSFMNTIHDIRKREKKLLEKA 340

  Fly   309 SYIRGILLSFIIFLTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAE 373
            .|::....:....::.::|..:...::.|...||..|||.:.|.:|:::.::.: .|..:..:||
  Rat   341 GYVQSGNSALAPIVSTIAIVSTFTCHIFLKRTLTAPVAFSVIAMFNVMKFSIAI-LPFSVKAVAE 404

  Fly   374 TLVSIKRVQKYM----------QSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLG 428
            ..||::|::|.:          |.::.:.:.:..:.|..::   ||.....|..:..:....:..
  Rat   405 ASVSLRRMKKILVAKSPPSYITQPEDPDTILLLANATLTWE---QEINRKRGPLKTQDQRRHVFK 466

  Fly   429 PPIATVNENAKLSEAGISI----SGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSL 489
            ...|.:.....||:.|::.    ||        ||...|:.::..|:.|.:|||.|..|||||||
  Rat   467 KQRAELYSEQSLSDQGVASPERQSG--------SPKSVLHNISFVVRKGKVLGICGNVGSGKSSL 523

  Fly   490 IQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFEL 554
            |.|:||::..:.|.:.|:|.::|.||:.|:|.|.||:|||||:..:.:||...|..|.|::|...
  Rat   524 ISALLGQMQLQKGVVAVSGPLAYVSQQAWIFHGNVRENILFGEKYNHQRYQHTVHVCGLQKDLNS 588

  Fly   555 LPFKDKT-------IVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQC 612
            ||:.|.|       .:||||.:|||||:.|||||||||....:|||||||||||.||.:|:||:|
  Rat   589 LPYGDLTECHYPHLQIGERGVNLSGGQRQRISLARAVYANRQLYLLDDPLSAVDAHVGKHVFEEC 653

  Fly   613 MRGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLDFASML--------ADP 669
            ::..|:.:.|:|.|||||||:..|::::::.|.:...||::.|.|....:|.::        .||
  Rat   654 IKKTLKGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDP 718

  Fly   670 ERDEQSEERSRSRSGSYTHSHS---------DQRRNSEQSLLSMADSCMDDLEAE---------- 715
            |                 |.::         .|.:..|.::|:..|...:..|.|
  Rat   719 E-----------------HIYNVAMVETLKESQAQRDEDAVLASGDERDEGKEPETEEFVDIKAP 766

  Fly   716 --QANNQERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVA 778
              |....|..:.|.:..:.|..|.||.||:...|:::....|..|.::...::|..|:.....|.
  Rat   767 VHQLIQIESPQEGIVTWKTYHTYIKASGGYLVSFLVLCLFFLMMGSSAFSTWWLGLWLDSGSQVI 831

  Fly   779 YRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDT--------YIFTVITVLTILVTVARSFLF 835
            ....:|:|                 ..:|:..:.||        ||.::::|||.  .:.:.|.|
  Rat   832 CAPQSNET-----------------ACNVNQTLQDTKHHMYQLVYIASMMSVLTF--GIIKGFTF 877

  Fly   836 FNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALA 900
            .|..:.||..|||.:|..|..:.|.||:|.|:||::|||||||.::|..||....:.:|.|..:.
  Rat   878 TNTTLMASSSLHNRVFNKIVSSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFSMVV 942

  Fly   901 GIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRA 965
            .|::::|...|:.|:....|.|:|:.|...:.:..:::|::|.|:|||.:||:.:|:.||..|.|
  Rat   943 FILVIMAASFPVVLVVLAGLAILFFILLRIFHRGVQELKQVENISRSPWFSHITSSMQGLGVIHA 1007

  Fly   966 FGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCF--CVIYIA--IITLSFFIFPPANGGD 1026
            :..:....::|....|.:||....|....|.|...:|..  .|.::.  ::|||   |...:...
  Rat  1008 YDKKDDCISKFKALNDENSSHLLYFNCALRWFALRMDILMNIVTFVVALLVTLS---FSSISASS 1069

  Fly  1027 VGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEY-EDIEPE-------GALEAPADKKPPK 1083
            .||:::..:.::|::|..:|...|.:...|:.|.:.|| ....||       |..        ||
  Rat  1070 KGLSLSYIIQLSGLLQVCVRTGTETQAKFTSAELMREYISTCVPEHTQSFKVGTC--------PK 1126

  Fly  1084 SWPEQGKIVFDELSLRY---TPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-S 1144
            .||.:|:|.|.:..:||   ||     .||..|:..|:..:.||||||||:|||||..||||| .
  Rat  1127 DWPSRGEITFKDYRMRYRDNTP-----LVLDGLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVE 1186

  Fly  1145 YNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKE 1209
            ...|::.||:.|...:||.:||:|:::|||:||||.||:||||||...::|:.||..||...:::
  Rat  1187 PASGTIFIDEVDICTVGLEELRTKLTMIPQDPVLFVGTVRYNLDPLGSHTDEMLWHVLERTFMRD 1251

  Fly  1210 VVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNK 1274
            .:..||..||:::||.|.|||||:|||:|:|||:||.::|:::|||||::|.:||.|:|:||:..
  Rat  1252 TIMKLPEKLQAEVTENGENFSVGERQLLCMARALLRNSKIILLDEATASMDSKTDTLVQSTIKEA 1316

  Fly  1275 FKECTVLTIAHRLHTIMDSDKVLVMDAGR-----AVEFGTPYELLTLADS 1319
            ||.||||||||||:|:::.|.||||:.|:     .:||..|..|....||
  Rat  1317 FKSCTVLTIAHRLNTVLNCDLVLVMENGKVQEVLVIEFDKPEVLAEKPDS 1366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	438/1393 (31%)
		ABC_membrane	107..360	CDD:294371	65/259 (25%)
		ABCC_MRP_domain1	445..645	CDD:213217	94/210 (45%)
		ABC_membrane	815..1014	CDD:294371	64/202 (32%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	113/229 (49%)
Abcc12	XP_008770597.1	CFTR_protein	44..1348	CDD:273530	434/1379 (31%)
		ABC_membrane	127..388	CDD:294371	67/267 (25%)
		ABCC_MRP_domain1	487..686	CDD:213217	94/206 (46%)
		ABC_membrane	802..1084	CDD:294371	81/303 (27%)
		ABCC_MRP_domain2	1132..1357	CDD:213211	113/229 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345073
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.660