DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and Abcc9

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_037172.2	Gene:	Abcc9 / 25560	RGDID:	3787	Length:	1545	Species:	Rattus norvegicus

Alignment Length:	1422	Identity:	436/1422 - (30%)
Similarity:	716/1422 - (50%)	Gaps:	212/1422 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NFISAACFWYTMPTFIKGRKRTLDTKDL------------YRALKE------HKSETLGNKLCAS 64
            |.:|.|.:|:.....|...::.:|.|.:            |..|||      .|:....|:..:.
  Rat   221 NLLSKATYWWMNTLIISAHRKPIDLKAIGKLPIAMRAVTNYVCLKEAYEEQKKKAADHPNRTPSI 285

  Fly    65 WELELEKTKGKPNLLRALLRVFGWYFA-LLGLVLFLLELGL--RTLQPIFLLKLIAYYTHGSESI 126
            | |.:.:..|:|.||.:..|    |.| |||....|...|:  |..:|.......:......|.:
  Rat   286 W-LAMYRAFGRPILLSSTFR----YLADLLGFAGPLCISGIVQRVNEPKNNTTRFSETLSSKEFL 345

  Fly   127 ESAYYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKS--ALGDTTAGHV 189
            |:|:..|..:.|...|....:......|:..|:.:|..:.:|||.|.||||.|  ::|:.|.|.:
  Rat   346 ENAHVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQI 410

  Fly   190 VNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTS 254
            .||::.:..:|.........||..|::.:....|:|..:|.:|:.|.|.::|..|:|.::..:.:
  Rat   411 NNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLA 475

  Fly   255 VLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFI 319
            ..:..|...:.||::..|||:.||:::|:||||..|...|...|.||:::::          :|.
  Rat   476 EAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLK----------TFA 530

  Fly   320 IFLTRVSIFLSLVGYV--LLGTFLT----------PEVAFLITAYYNILRTTMTVFFPQGISQMA 372
            :: |.:|||::....:  :|.||:|          |..||...:.::||.|.:  |....:.:.|
  Rat   531 LY-TSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPL--FLLSTVVRFA 592

  Fly   373 -ETLVSIKRVQKYMQSDETNVMDMSVDLTED----------FQGSNQET--------------VH 412
             :.::|::::.:::.|||         :.||          |:...:.|              .|
  Rat   593 VKAIISVQKLNEFLLSDE---------IGEDSWRTGEGTLPFESCKKHTGVQSKPINRKQPGRYH 648

  Fly   413 ADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLG 477
            .|..|:.     :.|.|        |:..:..|.::.....|  .|...:|:.:::|:..|.:..
  Rat   649 LDNYEQA-----RRLRP--------AETEDVAIKVTNGYFSW--GSGLATLSNIDIRIPTGQLTM 698

  Fly   478 IVGRTGSGKSSLIQAILGELPAESGEIKVNG-----------------SMSYASQEPWLFSGTVR 525
            |||:.|.|||||:.|||||:....|::..|.                 |::||:|:|||.:.||.
  Rat   699 IVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVE 763

  Fly   526 QNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSI 590
            :||.||...:|:||..|...|:|:.|.:||||.|:|.:||||.:|||||:.||.:|||:|:.|:|
  Rat   764 ENITFGSSFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNI 828

  Fly   591 YLLDDPLSAVDTHVARHLFEQCMRGYLRE--RIVILATHQLQFLQHADQIVIMDKGRVSAVGTYE 653
            ..||||.||:|.|::.||.::.:..:|::  |.|:|.||:||:|.|||.|:.|..|.|...||.:
  Rat   829 VFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGTLK 893

  Fly   654 SLRESGLDF------------ASMLADPERDEQSEERSRSRSGSYTHSHSDQRRNSEQSLLSMAD 706
            .::...::.            ..:..|.|.|:.:.||...|...|:..               |.
  Rat   894 DIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSRE---------------AK 943

  Fly   707 SCMDDLEAEQANNQERQEAGQIGLRLYSK-------YFKAGGGFFAFFVMMGFCVLSQGLASLGD 764
            :.|:|.:.|:...::..:.....:||.:|       ::...||||..|:|:...:|...:....|
  Rat   944 AQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWWYLTSGGFFLLFLMIFSKLLKHSVIVAID 1008

  Fly   765 YFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYI--FTVITVLTILV 827
            |:|:.|.::     |..  ||..::::                     ..|:  |:::....|.:
  Rat  1009 YWLATWTSE-----YSI--NDPGKADQ---------------------TFYVAGFSILCGAGIFL 1045

  Fly   828 TVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDV 892
            .:..|.....:.:.|:..||:::...|....:.||:|.|.|.||||||.|...:|:.:|..:..:
  Rat  1046 CLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESL 1110

  Fly   893 IQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASL 957
            .:..|.....:.:|:...|:|||....||:.||.::.::...|:|::.::..|:.|:..|.:.:.
  Rat  1111 TRSTLLCLSAIGMISYATPVFLIALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETA 1175

  Fly   958 TGLSTIRAFG-----AQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDC------FCVIYIAI 1011
            .||:|||||.     .||:||....|      :..|:|:|   |...||:.      .|::..|.
  Rat  1176 EGLTTIRAFRHETRFKQRMLELTDTN------NIAYLFLS---AANRWLEVRTDYLGACIVLTAS 1231

  Fly  1012 ITLSFFIFPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAP 1076
            |.   .|...:|.|.|||.:..|:.:|..:.|.:|..|:||..|.||::|..:..:|.|......
  Rat  1232 IA---SISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTM 1293

  Fly  1077 ADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALF 1141
            ...:.|:.||::|:|...:|.:||..:.|.  |||.:...|||.:||||.||||:|||||..|.|
  Rat  1294 DPSQVPEHWPQEGEIKIHDLCVRYENNLKP--VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFF 1356

  Fly  1142 RL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEV 1205
            |: ...||.::||..|.|::.||.|||::|||.|:|:||||::|:||||..:.:||:||.:||..
  Rat  1357 RMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIA 1421

  Fly  1206 KLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTT 1270
            :||.:|..||.||.:.:||||.|||||||||.|||||.:|::.||:||||||::|..|:.::|..
  Rat  1422 QLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKV 1486

  Fly  1271 IRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVK 1327
            :...|.:.||:|||||:|||:.:|.|:||..|..:|:.||..||...|. ||...|:
  Rat  1487 VMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQEDG-VFASFVR 1542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	431/1408 (31%)
		ABC_membrane	107..360	CDD:294371	70/266 (26%)
		ABCC_MRP_domain1	445..645	CDD:213217	89/218 (41%)
		ABC_membrane	815..1014	CDD:294371	58/211 (27%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	113/221 (51%)
Abcc9	NP_037172.2	MRP_assoc_pro	222..1542	CDD:188098	434/1419 (31%)
Abcc9	NP_037172.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..963		4/37 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345041
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650