DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and abc2

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_593943.3	Gene:	abc2 / 2543193	PomBaseID:	SPAC3F10.11c	Length:	1478	Species:	Schizosaccharomyces pombe

Alignment Length:	1376	Identity:	435/1376 - (31%)
Similarity:	712/1376 - (51%)	Gaps:	154/1376 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 HCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTKGKPNLLR 80
            :.|..|...|.:..|....|.:..|...|.:......:|..|......:|....:|.|..
pombe   194 YANIFSRISFGWLSPLMKFGYRNYLTESDAWSLPPAERSSNLTIVFEKNWISHAKKKKSS----- 253

  Fly    81 ALLRVFG------WYFALLGLVLFLLELGLRTLQPIFLLKLI----AYYTHGSESIESAYYYAAG 135
              |.::|      |...::.:||.|::..:..:||..:.|::    :|.:...:..:..:..|..
pombe   254 --LYMWGVLFLNHWKLTVVIIVLKLVQDVVAFIQPNLIRKIVIFVSSYSSEHPQPPQVGFSLAIA 316

  Fly   136 VILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVGRL 200
            :.|.:.:...::..|....|.:|::.|..:.:.||||:||||.:|....:.|.:||.||.|..::
pombe   317 MFLTNVVQTALLQQYFQLGMVLGMRWRSELITAIYRKSLRLSSAARQSRSVGDIVNYMSVDTQKV 381

  Fly   201 DLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTALRTD 265
            ...|:|:..:..||.:.:.....:|..:|..|:.|.....|..|....:.......:.|.....|
pombe   382 CDLTMFLFVIVSGPFQIVLALTNLYHLVGYGALSGAFVTFLLFPCNVVIASIFKRFQNRQMKNKD 446

  Fly   266 ERVRMMNEIISGIQVIKMYAWELPF-EHMVAFARKKEINAIRHVSYIR----------GILLSFI 319
            .|.:.|.|||:.|:.||:||||..| :.::.....:|:..::.:..:.          .||:|..
pombe   447 ARSQFMTEIINNIRSIKLYAWENIFLQKLLQLRNTRELRMLKKIGIVNTIGNFTWLFAPILVSAA 511

  Fly   320 IFLTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKY 384
            .|.|    |:.|.|...:   |:.::.|...:.:|:|:..:|: .|..:|.:.|..|:|.|:..:
pombe   512 TFGT----FIVLYGKTRV---LSVDIVFACLSLFNLLQFPLTM-LPIVVSSVLEASVAISRIYGF 568

  Fly   385 MQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISG 449
            :.:.|.:              ||                      .:.....|.:.|...:.|..
pombe   569 LTAGELD--------------SN----------------------AVQRYPANKEPSGVCLEIKK 597

  Fly   450 LMAKWD---VNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMS 511
            ....|.   .|:.:.:|..::...:.|.:..|||:.|.|||||::|.||.:...||.:...||::
pombe   598 GTFSWSGPGQNAAEPTLRDIDFVARRGELCCIVGKVGMGKSSLLEACLGNMQKHSGSVFRCGSIA 662

  Fly   512 YASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKA 576
            ||:|:||:.:.|:::|||||..:|...|.|.::.|.|.||||:|...|:|.|||:|.||||||||
pombe   663 YAAQQPWILNATIQENILFGLELDPEFYEKTIRACCLLRDFEILADGDQTEVGEKGISLSGGQKA 727

  Fly   577 RISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCM--RGYLRERIVILATHQLQFLQHADQIV 639
            |||||||||..:.||||||.|||||.||.|.|....:  :|.||.|.|||:|:.|..|:.|..|.
pombe   728 RISLARAVYSRSDIYLLDDILSAVDQHVNRDLVRNLLGSKGLLRSRCVILSTNSLTVLKEASMIY 792

  Fly   640 IMDKGRVSAVGTYESLRES-GLDFASMLAD-PERDEQSE---ERSRSRSGSYTHSHSDQRRNSEQ 699
            ::..|::...|::..|..| ......:|:: .::|..|.   :...|||.|...|.:|...::.:
pombe   793 MLRNGKIIESGSFTQLSSSPDSQLFQLLSEFSKKDTASSTGADTPLSRSQSVITSSTDVTSSASR 857

  Fly   700 SLLSMAD-------------SCMDDLEAEQANNQ--ERQEAGQIGLRLYSKYFKAGGGFFAFFVM 749
            |..::::             ..:.|.:..:|..|  |:.|.|::..::|..||||...|..|...
pombe   858 SSDTVSNYPKATIKGTGRIRKRLTDEDNVKATGQAAEKMERGKVKWKVYWTYFKACSLFLIFLYF 922

  Fly   750 MGFCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDT 814
            : |.:...|:....:.:|.:|......:.|             .|:...:|.
pombe   923 L-FIIGGIGMNVGTNVWLKHWSEVNTQLGY-------------NPKPYFYLG------------- 960

  Fly   815 YIFTVITVLT-ILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDM 878
             |:|:..:|: .|::::...:....|:|:...||:||.:.:.||.|.||.|.|:||||||||.|:
pombe   961 -IYTLFGLLSCALISLSSLTITVFCAIKSCRYLHDSMVKAVLRAPMSFFETTPTGRILNRFSSDV 1024

  Fly   879 GQVDEILPAVMMDVIQIFLALAGIVIVIAVV---NPLFLIPTVVLGIIFYQLRTFYLKTSRDVKR 940
            .:|||::..|.|   ..|..|..||.|:||:   :|:|:|..|.|..::...:.:|.:|||::||
pombe  1025 YRVDEVISRVFM---FFFRNLFQIVFVLAVICYSSPMFMILIVPLFFLYRYNQVYYTQTSRELKR 1086

  Fly   941 MEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYW--LDC 1003
            ::::||||:|:|...||.|||||||:..:....:|.|...|.:...::::.|::|    |  :..
pombe  1087 LDSVTRSPLYAHFQESLGGLSTIRAYDMEDTFISENDIRVDTNHRIWFLYFSSNR----WQAIRV 1147

  Fly  1004 FCVIYIAIITLSFF-----IFPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVE 1063
            ..:..:.:.:.:||     :....|.|.|||:::.|:.:|..:.:.:|||.::|..:.:|||::|
pombe  1148 EAIGALVVFSSAFFGVLSAVRGNPNSGLVGLSLSYAVQITQSLTFVVRQSVDVETNIVSVERMLE 1212

  Fly  1064 YEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSEN---VLKSLSFVIKPKEKVGI 1125
            |..:..|.....| |.:||:.||..|.|.||..|:||     .||   ||..:|..|||:||:||
pombe  1213 YIGLPSEAPSIIP-DHRPPEGWPSHGAIKFDHYSVRY-----RENLPLVLNDISVNIKPQEKIGI 1271

  Fly  1126 VGRTGAGKSSLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDP 1189
            |||||||||:|..||||| ....|.:.:|..:.:.:|||||||:::|||||...|.||:|.||||
pombe  1272 VGRTGAGKSTLTLALFRLIEPTSGDIQLDDINITSIGLHDLRSRLAIIPQENQAFEGTIRENLDP 1336

  Fly  1190 FDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDE 1254
            ....:|:::|.:||...||:.:..|..||.|::||||.|.|.|||||:||.||:|...|:|::||
pombe  1337 NANATDEEIWHALEAASLKQFIQTLDGGLYSRVTEGGANLSSGQRQLMCLTRALLTPTRVLLLDE 1401

  Fly  1255 ATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADS 1319
            |||.||.:||.::|.|||.:|.:.|:||||||::|:|||:::||:|.|:.|||.:..:||. ..:
pombe  1402 ATAAVDVETDAIVQRTIRERFNDRTILTIAHRINTVMDSNRILVLDHGKVVEFDSTKKLLE-NKA 1465

  Fly  1320 KVFHGMVKQTG 1330
            .:|:.:.|::|
pombe  1466 SLFYSLAKESG 1476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	431/1359 (32%)
		ABC_membrane	107..360	CDD:294371	63/267 (24%)
		ABCC_MRP_domain1	445..645	CDD:213217	92/204 (45%)
		ABC_membrane	815..1014	CDD:294371	70/204 (34%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	116/224 (52%)
abc2	NP_593943.3	MRP_assoc_pro	96..1477	CDD:188098	435/1376 (32%)
		ABC_membrane	272..545	CDD:279056	66/279 (24%)
		ABCC_MRP_domain1	593..798	CDD:213217	92/204 (45%)
		ABC_membrane	928..1190	CDD:279056	85/295 (29%)
		ABCC_MRP_domain2	1237..1456	CDD:213211	116/223 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720