DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and abc4

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_594558.1	Gene:	abc4 / 2543059	PomBaseID:	SPAC30.04c	Length:	1469	Species:	Schizosaccharomyces pombe

Alignment Length:	1328	Identity:	400/1328 - (30%)
Similarity:	651/1328 - (49%)	Gaps:	155/1328 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 CNFISAAC-FWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTKGKPNLLR 80
            |:..:.|| :.|..|..:..::|.::..|. ..:.::..    ||   :|....|:.| .|:|..
pombe   231 CSMFNFACSYGYLNPLVLTAKRRVVEVDDT-PVIPDYDK----NK---AWTYRFERMK-TPSLFI 286

  Fly    81 ALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYTHGSESIESAYYYAAGVILCSALNVI 145
            .:.::|......:|:..|::.: .:.|.||.|.:|:.:....|.|..:...:...::....|..:
pombe   287 TIHKIFWRQILGMGVSSFMVSV-CQFLSPIALNRLLKHLESPSSSSVNPLVWIVLLLTGPFLTSL 350

  Fly   146 IMHPYMLGTMHVGLKMRVGMCSMIYRKAL--RLSKSALGDTTAGHVVNLMSNDVGRLDLATIFVH 208
            ....|:..:.....:....:...||.|.:  |..::..||:..|...||:|.||..:.....|:|
pombe   351 FTQFYLFMSTRYLARSYTTLVQQIYNKVIRSRFVQNKSGDSKVGRSNNLISTDVDDIGEIREFIH 415

  Fly   209 YLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNE 273
            .:...|:|.....||:.:.:|.:|..|:|..:|...:...||...:.|.||....||.|:.:|:|
pombe   416 IIVRAPVEIAGSIYLLQKLLGWSAYVGLALTVLTCSVPIVLGPLVAKLTLRANRATDSRIELMSE 480

  Fly   274 IISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFLTRVSIFLSLVGY-VLL 337
            ::..|::.|.:.||||....|...|:.|:|....:..:...:...:..|...|:|.:.|.: .::
pombe   481 LLQSIRITKFFGWELPMLDRVKQRRQVELNRTWKLLLMEICIQVLVESLPVFSMFATFVVFTTIM 545

  Fly   338 GTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTED 402
            |..:||.:||...:.::.:||..: :....:.|:.:..|||.||..::
pombe   546 GQTITPSIAFTSISLFSFIRTQFS-WIAYLMRQIVQIFVSIGRVSDFL----------------- 592

  Fly   403 FQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVN-SP-DYSLNG 465
                          .:.||.:      |:.|:.:.::  |.|...:.|  .|..| || |:.|..
pombe   593 --------------NDPDEVD------PVNTIEDTSQ--EIGFFNASL--TWVSNPSPGDFCLRD 633

  Fly   466 VNLRVQPGTMLGIV-GRTGSGKSSLIQAILGELPAESGEIKVNGS--MSYASQEPWLFSGTVRQN 527
            :|: |.|...|.|| |.|||||||||.|:||||....|...:..|  :||.||.|||.:.|:|.|
pombe   634 LNI-VFPRNKLSIVIGPTGSGKSSLISALLGELSLNKGSYNLPRSKGVSYVSQVPWLRNATIRDN 697

  Fly   528 ILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYL 592
            |||..|....||.||::.|.|..|.:.....|.|.:||:|.:||||||.||:||||||..|||.|
pombe   698 ILFDYPYIEERYKKVIQACGLLTDLQSFVASDLTEIGEKGVTLSGGQKQRIALARAVYSPTSIVL 762

  Fly   593 LDDPLSAVDTHVARHLFEQCMRGYLRE-RIVILATHQLQ-FLQHADQIVIMDKGRVSAVGTYESL 655
            :||..||:|.|.:..:::.|.:..|.| |.|||.||.:. |:..|..||.:..|....|    :.
pombe   763 MDDVFSALDIHTSNWIYKHCFQSSLMENRTVILVTHNVHLFMDSAAFIVTVKNGSAFPV----TD 823

  Fly   656 RESGLDFASMLADPERDEQSEERSRSRSGSYTHSHSDQRRNSEQSLLSMADSCMDDLEAEQANN- 719
            :.|.|.|.:        ||:...|.:.:             .:.:.:.:.:. :||.||....:
pombe   824 KSSPLLFLA--------EQAASASEAAA-------------PDLAAIPIPNE-VDDAEAADEKDG 866

  Fly   720 ----QERQEAGQI---GLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNV 777
                :|::..|.:   .:..|.|:|  |.||:...|:: |.|.:|..:.|.|.::::|.....|
pombe   867 KLVEEEQRVTGDVVFSEIFSYMKHF--GSGFYVAAVLL-FFVTTQATSILIDLWVAFWTNSSVN- 927

  Fly   778 AYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKA 842
            :...:||..                  |.|...||..|     ::|..|.||:    :...|..|
pombe   928 SPDVNNNKF------------------LFVYGTMLLAY-----SLLDFLRTVS----YDRGAWWA 965

  Fly   843 SIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIA 907
            |.:||:||...:......:|:..|:|||:|||:||:..:|..|...:...|..||::||.::.::
pombe   966 SRKLHDSMLESVFGTFASWFDKTPTGRIVNRFAKDIRSIDMNLSGWLFFSINCFLSVAGGILSVS 1030

  Fly   908 VVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVL 972
            ...|:|:||.|::.:..|.....|.:....|||:.:|..||::|.|..|:.|:|.||||..|.:.
pombe  1031 SAMPIFMIPAVIVCLAGYYFGLLYTRAQVGVKRLISIYTSPIFSLLGESIVGVSVIRAFNRQTIF 1095

  Fly   973 EAEF----DNYQDMHSSAFYMFISTSRAFGYWLDCFCVIYIAIITLSFFIFPPANGGDVGLAITQ 1033
            :..|    ||...:.|:::    :.:|......|....:..||..|...:....:.|.||.::.|
pombe  1096 KQMFSERLDNLVRLQSTSY----NLNRWVAVRTDGISGLVGAIAGLIALLQKDLSPGVVGFSLNQ 1156

  Fly  1034 AMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADK---KPPKSWPEQGKIVFDE 1095
            |:..:..|...:|....|:..|.:.|||:||..:..|     ||..   :.|.:||::|.|||:.
pombe  1157 AVIFSSSVLLFVRSCNSLQAEMNSYERVLEYSKLPQE-----PAPTIAGQVPATWPKEGDIVFNH 1216

  Fly  1096 LSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYN-DGSVLIDKRDTSE 1159
            :|:.|:  .....:||.::..|.|.|||.:|||||:|||:|...|.|.::. .|.:.|:.|:|..
pombe  1217 VSVSYS--AAGPTILKDVNLHINPSEKVAVVGRTGSGKSTLGLTLLRFTHRISGEIYINGRETQS 1279

  Fly  1160 MGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVV-------ADLPSG 1217
            :.|:.||.:||.|||:|:|||||:|.|||||||..|:.|..:|:......::       ..:...
pombe  1280 VNLNALRQRISFIPQDPILFSGTVRSNLDPFDELEDNFLNEALKTSGASSMIMAHTDDQKPIHIT 1344

  Fly  1218 LQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLT 1282
            |.:.:...|:|||.||:|::.|||||:|.::|:::||.||:||...|..||.|:|..|.:.|:|.
pombe  1345 LDTHVASEGSNFSQGQKQVLALARAIVRRSKIIILDECTASVDDAMDQKIQKTLREAFGDATMLC 1409

  Fly  1283 IAHRLHTIMDSDKVLVMDAGRAVEFGTP 1310
            |||||.||:|.|||:|:|.|..||:|.|
pombe  1410 IAHRLKTIVDYDKVMVLDKGVLVEYGPP 1437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	400/1328 (30%)
		ABC_membrane	107..360	CDD:294371	63/255 (25%)
		ABCC_MRP_domain1	445..645	CDD:213217	93/206 (45%)
		ABC_membrane	815..1014	CDD:294371	60/202 (30%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	99/228 (43%)
abc4	NP_594558.1	CFTR_protein	240..1449	CDD:273530	397/1319 (30%)
		ABC_membrane	300..568	CDD:294371	65/268 (24%)
		ABCC_MRP_domain1	611..817	CDD:213217	94/208 (45%)
		ABC_membrane	901..1164	CDD:294371	79/295 (27%)
		ABCC_MRP_domain2	1210..1437	CDD:213211	99/228 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810