DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7627 and Abcb4

DIOPT Version :9

Sequence 1:NP_001245943.1 Gene:CG7627 / 34148 FlyBaseID:FBgn0032026 Length:1355 Species:Drosophila melanogaster
Sequence 2:NP_036822.1 Gene:Abcb4 / 24891 RGDID:620248 Length:1278 Species:Rattus norvegicus


Alignment Length:1423 Identity:319/1423 - (22%)
Similarity:580/1423 - (40%) Gaps:313/1423 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 KLCASWEL-----ELEKTKGKPNLL--RALLRVFGW---YFALL----------GLVLFLLELG- 103
            :|...:||     :..:.|.|.||:  ..|.|...|   .|.||          ||.|.::..| 
  Rat    13 RLDGDFELGSISNQSREKKKKVNLIGPLTLFRYSDWQDKLFMLLGTAMAIAHGSGLPLMMIVFGE 77

  Fly   104 -------------------LRTLQPIFLLKLIAYYTHGSESIESAYYYA---AGVILCSALNVII 146
                               |..|.|..:|:        .|....||||:   .||:|.:.:.|  
  Rat    78 MTDKFVDNAGNFSLPVNFSLSMLNPGRILE--------EEMTRYAYYYSGLGGGVLLAAYIQV-- 132

  Fly   147 MHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVGRLD---------- 201
                ...|:..|.::| .:....:...||.............:...:::|:.::.          
  Rat   133 ----SFWTLAAGRQIR-KIRQKFFHAILRQEMGWFDIKGTTELNTRLTDDISKISEGIGDKVGMF 192

  Fly   202 ---LATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTALR 263
               :||.|..:: ||.:....:|.::   :.|.|:.|::..:....|..:..|..:......|:.
  Rat   193 FQAIATFFAGFI-VGFIRGWKLTLVI---MAITAILGLSTAVWAKILSTFSDKELAAYAKAGAVA 253

  Fly   264 TDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINA---------IRHVSYIRGILLSFI 319
            .:....:...|..|.|..::..::...|:......||.|:|         :.:.||.........
  Rat   254 EEALGAIRTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGST 318

  Fly   320 IFLTR-------VSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVS 377
            :.:::       :::|.|    :|:|.|...:.|..|.|:.|.......:|              
  Rat   319 LVISKEYTIGNAMTVFFS----ILIGAFSVGQAAPCIDAFPNARGAAYVIF-------------- 365

  Fly   378 IKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSE 442
                         :::|.:..:              |...||....|.:.|        |.:.|:
  Rat   366 -------------DIIDNNPKI--------------DSFSERGHKPDSIKG--------NLEFSD 395

  Fly   443 --------AGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPA 499
                    |.|.|               |.|:||:|:.|..:.:||.:|.|||:.:|.:......
  Rat   396 VHFSYPSRANIKI---------------LKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDP 445

  Fly   500 ESGEIKVNGS-------------MSYASQEPWLFSGTVRQNILFGQ---PMDRRRYAKVVKKCAL 548
            ..|.|.::|.             :...||||.|||.|:.:||.:|:   .||..:  |.||: |.
  Rat   446 TEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIK--KAVKE-AN 507

  Fly   549 ERDFEL-LPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQC 612
            ..||.: ||.|..|:||:|||.||||||.||::|||:.|...|.|||:..||:||.....:  |.
  Rat   508 AYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV--QA 570

  Fly   613 MRGYLRE-RIVILATHQLQFLQHADQIVIMDKGRVSAVGTY-ESLRESGLDF---------ASML 666
            .....|| |..|:..|:|..:::||.|...:.|.:...|:: |.:::.|:.|         :.:|
  Rat   571 ALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIKKEGIYFRLVNMQTSGSQIL 635

  Fly   667 ADPERDEQSEERSRSRSGSYTHSHSDQR--RNSEQSLLSMADSCMDDLEAEQANNQERQEAGQIG 729
            ::....|.|:|::   :|....:....|  |||.:..|..:.:..:.|:.|  .|:.......:.
  Rat   636 SEEFEVELSDEKA---AGGVAPNGWKARIFRNSTKKSLKSSRAHQNRLDVE--TNELDANVPPVS 695

  Fly   730 LRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEP 794
               :.|..:.....:.:||:...|.::.|...     .::.:.....:|.....:||.:.::.. 
  Rat   696 ---FLKVLRLNKTEWPYFVVGTLCAIANGALQ-----PAFSIILSEMIAIFGPGDDTVKQQKCN- 751

  Fly   795 RLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAM 859
                             :.:.:|..:.|.:......:.|.|.......:.||.:..|:.:.|..|
  Rat   752 -----------------MFSLVFLGLGVHSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDM 799

  Fly   860 YFF--NTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNP-------LFLI 915
            .:|  :.|.:|.:..|.:.|..|| :......:.:|....|..|..|:|:.:..       |.::
  Rat   800 SWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVV 863

  Fly   916 PTV-VLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNY 979
            |.: |.||:  :::.......||.|.|||..:.     ...::..:.|:.:...:|..|:.:  .
  Rat   864 PFIAVAGIV--EMKMLAGNAKRDKKEMEAAGKI-----ATEAIENIRTVVSLTQERKFESMY--V 919

  Fly   980 QDMH---------SSAFYMFISTSRAFGY--WLDCFCVIYIAIITLSFFIFPPANG----GDVGL 1029
            :.:|         :..:.:..|.|:||.|  :..||          .|..:...||    .||.|
  Rat   920 EKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCF----------RFGSYLIVNGHMRFKDVIL 974

  Fly  1030 AITQAMGMTGMVQWGMRQS-------AELENT--MTAVERVVEYEDIEPEGALEAPADKKPPKSW 1085
            ..:..  :.|.|..|...|       |:|...  .:..||....:....||            .|
  Rat   975 VFSAI--VLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSREG------------MW 1025

  Fly  1086 PE--QGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYND- 1147
            |:  :|.:.|:|:...| |...:..||:.||..:|..:.:.:||.:|.|||:::..|.|. |:. 
  Rat  1026 PDKFEGSVTFNEVVFNY-PTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERF-YDPM 1088

  Fly  1148 -GSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNL---DPFDEYSDDKLWRSLEEVKLK 1208
             |:||:|.::..::.:..||:::.|:.|||:||..::..|:   |.....|.|::.|:.:|..:.
  Rat  1089 AGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAKNIAYGDNSRVVSQDEIVRAAKEANIH 1153

  Fly  1209 EVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRN 1273
            ..:..||...::::.:.||..|.||:|.:.:|||::|:.|:|::||||:.:|.:::.::|..:..
  Rat  1154 PFIETLPQKYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDK 1218

  Fly  1274 KFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVK-QTG 1330
            ..:..|.:.|||||.||.::|.::|:|.|:..|.||..:|  ||...::..||. |.|
  Rat  1219 AREGRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQL--LAQKGIYFSMVNIQAG 1274

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7627NP_001245943.1 CFTR_protein 12..1315 CDD:273530 313/1405 (22%)
ABC_membrane 107..360 CDD:294371 49/284 (17%)
ABCC_MRP_domain1 445..645 CDD:213217 76/217 (35%)
ABC_membrane 815..1014 CDD:294371 43/219 (20%)
ABCC_MRP_domain2 1089..1310 CDD:213211 71/225 (32%)
Abcb4NP_036822.1 PTZ00265 29..1271 CDD:240339 314/1402 (22%)
ABC_membrane 58..342 CDD:279056 49/306 (16%)
ABC_MTABC3_MDL1_MDL2 392..628 CDD:213216 83/255 (33%)
Interaction with HAX1. /evidence=ECO:0000269|PubMed:15159385 622..646 4/23 (17%)
ABC_membrane 714..984 CDD:279056 55/314 (18%)
ABC_MTABC3_MDL1_MDL2 1033..1272 CDD:213216 76/242 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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