DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and Abcc9

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_035641.1	Gene:	Abcc9 / 20928	MGIID:	1352630	Length:	1546	Species:	Mus musculus

Alignment Length:	1429	Identity:	437/1429 - (30%)
Similarity:	716/1429 - (50%)	Gaps:	225/1429 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NFISAACFWYTMPTFIKGRKRTLDTKDL------------YRALKE------HKSETLGNKLCAS 64
            |.:|.|.:|:.....|...::.:|.|.:            |..|||      .|:....|:..:.
Mouse   221 NLLSKATYWWMNTLIISAHRKPIDLKAIGKLPIAMRAVTNYVCLKEAYEEQKKKAADHPNRTPSI 285

  Fly    65 WELELEKTKGKPNLLRALLRVFGWYFA-LLGLVLFLLELGL--------RTLQPIFLLKLIAYYT 120
            | |.:.:..|:|.||.:..|    |.| |||....|...|:        .|.:.:|...|
Mouse   286 W-LAMYRAFGRPILLSSTFR----YLADLLGFAGPLCISGIVQRVNEKTNTTREMFPETL----- 340

  Fly   121 HGSESIESAYYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKS--ALGD 183
            ...|.:|:|:..|..:.|...|....:......|:..|:.:|..:.:|||.|.||||.|  ::|:
Mouse   341 SSKEFLENAHVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGE 405

  Fly   184 TTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAY 248
            .|.|.:.||::.:..:|.........||..|::.:....|:|..:|.:|:.|.|.::|..|:|.:
Mouse   406 MTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYF 470

  Fly   249 LGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRG 313
            :..:.:..:..|...:.||::..|||:.||:::|:||||..|...|...|.||:::::
Mouse   471 IATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLK------- 528

  Fly   314 ILLSFIIFLTRVSIFLSLVGYV--LLGTFLT----------PEVAFLITAYYNILRTTMTVFFPQ 366
               :|.:: |.:|||::....:  :|.||:|          |..||...:.::||.|.:  |...
Mouse   529 ---TFALY-TSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPL--FLLS 587

  Fly   367 GISQMA-ETLVSIKRVQKYMQSDETNVMDMSVDLTED----------FQGSNQET---------- 410
            .:.:.| :.::|::::.:::.|||         :.||          |:...:.|
Mouse   588 TVVRFAVKAIISVQKLNEFLLSDE---------IGEDSWRAGEGTLPFESCKKHTGVQSKPINRK 643

  Fly   411 ----VHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQ 471
                .|.|..|:.     :.|.|        |:..:..|.::.....|  .|...:|:.:::|:.
Mouse   644 QPGRYHLDSYEQA-----RRLRP--------AETEDIAIKVTNGYFSW--GSGLATLSNIDIRIP 693

  Fly   472 PGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNG-----------------SMSYASQEPWL 519
            .|.:..|||:.|.|||||:.|||||:....|::..|.                 |::||:|:|||
Mouse   694 TGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWL 758

  Fly   520 FSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAV 584
            .:.||.:||.||.|.:|:||..|...|:|:.|.:||||.|:|.:||||.:|||||:.||.:|||:
Mouse   759 LNATVEENITFGSPFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARAL 823

  Fly   585 YRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRE--RIVILATHQLQFLQHADQIVIMDKGRVS 647
            |:.|:|..||||.||:|.|::.||.::.:..:|::  |.|:|.||:||:|.|||.|:.|..|.|.
Mouse   824 YQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVL 888

  Fly   648 AVGTYESLRESGLDF------------ASMLADPERDEQSEERSRSRSGSYTHSHSDQRRNSEQS 700
            ..||.:.::...::.            ..:..|.|.|:.:.||...|...|:..
Mouse   889 REGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSRE----------- 942

  Fly   701 LLSMADSCMDDLEAEQANNQERQEAGQIGLRLYSK-------YFKAGGGFFAFFVMMGFCVLSQG 758
                |.:.|:|.:.|:...::.::.....:||.:|       ::...||||..|:|:...:|...
Mouse   943 ----AKAQMEDEDEEEEEEEDEEDNMSTVMRLRTKMPWKTCWWYLTSGGFFLLFLMIFSKLLKHS 1003

  Fly   759 LASLGDYFLSYWVTKKG-NVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYI--FTVI 820
            :....||:|:.|.::.. |...:||..                             .|:  |:::
Mouse  1004 VIVAIDYWLATWTSEYSINHPGKADQT-----------------------------FYVAGFSIL 1039

  Fly   821 TVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEIL 885
            ....|.:.:..|.....:.:.|:..||:::...|....:.||:|.|.|.||||||.|...:|:.:
Mouse  1040 CGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHI 1104

  Fly   886 PAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVY 950
            |..:..:.:..|.....:.:|:...|:||:....||:.||.::.::...|:|::.::..|:.|:.
Mouse  1105 PPTLESLTRSTLLCLSAIGMISYATPVFLVALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLL 1169

  Fly   951 SHLAASLTGLSTIRAFG-----AQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDC------F 1004
            .|.:.:..||:|||||.     .||:||....|      :..|:|:|   |...||:.      .
Mouse  1170 CHFSETAEGLTTIRAFRHETRFKQRMLELTDTN------NIAYLFLS---AANRWLEVRTDYLGA 1225

  Fly  1005 CVIYIAIITLSFFIFPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEP 1069
            |::..|.|.   .|...:|.|.|||.:..|:.:|..:.|.:|..|:||..|.||::|..:..:|.
Mouse  1226 CIVLTASIA---SISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMES 1287

  Fly  1070 EGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKS 1134
            |.........:.|:.||::|:|...:|.:||..:.|.  |||.:...|||.:||||.||||:|||
Mouse  1288 ENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKP--VLKHVKAYIKPGQKVGICGRTGSGKS 1350

  Fly  1135 SLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKL 1198
            ||..|.||: ...||.::||..|.|::.||.|||::|||.|:|:||||::|:||||..:.:||:|
Mouse  1351 SLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRL 1415

  Fly  1199 WRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQT 1263
            |.:||..:||.:|..||.||.:.:||||.|||||||||.|||||.:|::.||:||||||::|..|
Mouse  1416 WEALEIAQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMAT 1480

  Fly  1264 DGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVK 1327
            :.::|..:...|.:.||:|||||:|||:.:|.|:||..|..:|:.||..||...|. ||...|:
Mouse  1481 ENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQEDG-VFASFVR 1543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	432/1415 (31%)
		ABC_membrane	107..360	CDD:294371	71/266 (27%)
		ABCC_MRP_domain1	445..645	CDD:213217	90/218 (41%)
		ABC_membrane	815..1014	CDD:294371	57/211 (27%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	113/221 (51%)
Abcc9	NP_035641.1	MRP_assoc_pro	23..1543	CDD:188098	436/1427 (31%)
Abcc9	NP_035641.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..964		4/37 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841667
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.640