DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and Abcc8

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	XP_036008753.1	Gene:	Abcc8 / 20927	MGIID:	1352629	Length:	1597	Species:	Mus musculus

Alignment Length:	1445	Identity:	446/1445 - (30%)
Similarity:	729/1445 - (50%)	Gaps:	208/1445 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NFISAACFWYTMPTFIK-GRKRTLDTKDL------YRALKEHKSETLGNKLCASWELELEK---- 71
            |.:|...:|: |..||| ..::.:|.:.:      .|||..::      :|||:::.:..|
Mouse   223 NLLSKGTYWW-MNAFIKTAHRKPIDLRAIGKLPIAMRALTNYQ------RLCAAFDAQARKDTQS 280

  Fly    72 TKGKPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLI------------------AY 118
            .:|...:.|||...||....|......|.:| |....|:.:..::                  .|
Mouse   281 QQGARAIWRALCHAFGRRLVLSSTFRILADL-LGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVY 344

  Fly   119 YTHGSESIESAYYYAAGVILCSALNVIIMHPYMLGTMHV----GLKMRVGMCSMIYRKALRLSKS 179
            :....|.:.:||..|  |:|..||  ::...::..:.:|    |:.:|..:.:.||.|.:.||.|
Mouse   345 FVSSQEFLGNAYVLA--VLLFLAL--LLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTS 405

  Fly   180 --ALGDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLF 242
              ::|:.|||.:.||::.|..:|.........||..|::.:....|:|..:|::|:.|.|.::|.
Mouse   406 NLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILL 470

  Fly   243 IPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRH 307
            .|:|.::..:.|..:..|...::||::..||::.||:::|:||||..|...|...|:||:.::|
Mouse   471 APVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFCSRVEMTRRKEMTSLR- 534

  Fly   308 VSYIRGILLSFIIFLTRVSIFLSL---VGYVLLGTFL-----------TPEVAFLITAYYNILRT 358
                     :|.:: |.:|||::.   :..||: ||:           :|.|||...:.::||.|
Mouse   535 ---------AFAVY-TSISIFMNTAIPIAAVLI-TFVGHVSFFKESDFSPSVAFASLSLFHILVT 588

  Fly   359 TMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTED---------------FQGSNQ 408
            .: ......:....:.|||::::.:::.|.|         :.|:               :|....
Mouse   589 PL-FLLSSVVRSTVKALVSVQKLSEFLSSAE---------IREEQCAPREPAPQGQAGKYQAVPL 643

  Fly   409 ETVHADGDEERDEAEDKLLGP-PIATVNENAKLSEAGISISGLMAKWDVNSPD--YSLNGVNLRV 470
            :.|:.. ...|:|..| |||| ...|.:.:.......:.|.|....|   :||  .:|:.:.:|:
Mouse   644 KVVNRK-RPAREEVRD-LLGPLQRLTPSMDGDADNFCVQIIGGFFTW---TPDGIPTLSNITIRI 703

  Fly   471 QPGTMLGIVGRTGSGKSSLIQAILGELPAESGEI------------------------------- 504
            ..|.:..|||:.|.|||||:.|.|||:...||.:
Mouse   704 PRGQLTMIVGQVGCGKSSLLLATLGEMQRVSGAVFWNSSLPDSEGEDPRYCLRTSNPERETAADS 768

  Fly   505 --KVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERG 567
              :..|.::||||:|||.:.||.:||.|..|.:::||..|::.|:|:.|.::||..|:|.:||||
Mouse   769 DARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERG 833

  Fly   568 ASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRE--RIVILATHQLQ 630
            .:|||||:.|||:|||:|:.|::..||||.||:|.|::.||.:..:...||:  |.|:|.||:||
Mouse   834 INLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQ 898

  Fly   631 FLQHADQIVIMDKGRVSAVGTYESLRESG---LDFASMLADPERDEQSEERSRSRSGSYTHSHSD 692
            :|.|||.|:.|..|.:...||.:..:.|.   .:....|.:.:..|..:|....|..........
Mouse   899 YLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLP 963

  Fly   693 QRRNSEQSLLSMADSCMDDLEAEQANNQE-------RQEAGQIGLRLYSKYFKAGGGFFAFFVMM 750
            :..:|...||  .|.  |:.|.|.|.::|       ..:..:|..|..:||..:.|     .:::
Mouse   964 RAMSSRDGLL--LDE--DEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAG-----VLLL 1019

  Fly   751 GFCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDA---EML 812
            ...|.||.|..:....:.||:.|..:.|.               .||...|:..||.:.   :.:
Mouse  1020 SLLVFSQLLKHMVLVAIDYWLAKWTDSAL---------------VLSPAARNCSLSQECALDQSV 1069

  Fly   813 DTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKD 877
            ...:|||:..|.|.:.:..|.......:|.:.|||.|:...|..|.|.||.|.|.|.||||||.|
Mouse  1070 YAMVFTVLCSLGIALCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSD 1134

  Fly   878 MGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRME 942
            ...:|:.:|:.:..:.:..|.....:.||:.|.|:||:..:.|.::.|.::.::...|||:::::
Mouse  1135 CNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLD 1199

  Fly   943 AITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDC---- 1003
            ..|:.|:.||.|.::.||:|||||..:...:.:...|.|.::.|.....:.:|    ||:.
Mouse  1200 DTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANR----WLEVRMPG 1260

  Fly  1004 -----------FCVIYIAIIT-LSFFIFPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMT 1056
                       .||:.||..| :|..:....:.|.|||.:|.|:.::..:.|.:|..|::|..:.
Mouse  1261 PAAVLPQEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLG 1325

  Fly  1057 AVERV---VEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIK 1118
            ||:|:   ::.|....||.|   |....||:||:||||....||:||  |...:.|||.::.:|.
Mouse  1326 AVKRIHTLLKTEAESYEGLL---APSLIPKNWPDQGKIQIQNLSVRY--DSSLKPVLKHVNALIA 1385

  Fly  1119 PKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGT 1182
            |.:|:||.||||:||||...|.||: ...:|.::||..|.:::.||.|||::|||.|:|||||||
Mouse  1386 PGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGT 1450

  Fly  1183 MRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILREN 1247
            :|:||||..:.||..||.:||..:||.||..||.||.:.|||||.|||.|||||.|||||.:|:.
Mouse  1451 IRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKT 1515

  Fly  1248 RILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYE 1312
            .|.:||||||::|..|:.::|..:...|.:.||:|||||:|||:.:|.|:|:..|..:||..|.:
Mouse  1516 SIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEK 1580

  Fly  1313 LLTLADSKVFHGMVK 1327
            ||:..|| ||...|:
Mouse  1581 LLSQKDS-VFASFVR 1594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	440/1431 (31%)
		ABC_membrane	107..360	CDD:294371	74/290 (26%)
		ABCC_MRP_domain1	445..645	CDD:213217	89/236 (38%)
		ABC_membrane	815..1014	CDD:294371	63/214 (29%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	112/221 (51%)
Abcc8	XP_036008753.1	MRP_assoc_pro	224..1594	CDD:188098	444/1442 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841687
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650