DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7627 and mrp-8

DIOPT Version :9

Sequence 1:NP_001245943.1 Gene:CG7627 / 34148 FlyBaseID:FBgn0032026 Length:1355 Species:Drosophila melanogaster
Sequence 2:NP_499598.2 Gene:mrp-8 / 190710 WormBaseID:WBGene00003414 Length:1461 Species:Caenorhabditis elegans


Alignment Length:1373 Identity:442/1373 - (32%)
Similarity:704/1373 - (51%) Gaps:159/1373 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LPENPREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTK 73
            :.:.|.|..:|:|...|.:..|....|.|:.|..:.|:...:...||.|..:    |..|.:|.|
 Worm   173 IEQTPEEKSSFLSKIFFCWLNPLIRAGAKQPLTNESLHNLNENATSEWLYTR----WRAEFDKEK 233

  Fly    74 -----GKPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYTHGSESIESAYYYA 133
                 |:.:::...:|:.......|.|.....:: :..|.||.|.:||.|.:...:.:......|
 Worm   234 AGRKSGETSIVWPFIRIQRATIITLTLARLTADI-VHYLNPILLKQLIDYVSLHDQPLSFGIAIA 297

  Fly   134 AGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVG 198
            ..:..||....::.:..:.|.....:..:..:.:.|..|.||||.||..:.|||.::|..:.|:.
 Worm   298 CIMFSCSTTRSLLQNYQIAGMCRQAVYYQTVLSNAILHKILRLSPSARSNRTAGEILNHAAVDIE 362

  Fly   199 RLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTALR 263
            .:..:..::..:|..|.:......::...:|.||:.||..|:|||||.....:...:.:.:....
 Worm   363 IIVHSVPYLQNMWSVPFQVTLAMTMLAITLGWAAMAGVCIMILFIPLNLCTSRFIKLSQQKQMKI 427

  Fly   264 TDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFLTRVSIF 328
            .|||.::.||:::||:|:|:||||..||..:...|.||:..:|:|.    ||...:......|.|
 Worm   428 KDERTKLSNEMLNGIKVVKLYAWEESFEDQINRLRAKEVKMLRNVC----ILSRIVDVANAASPF 488

  Fly   329 LSLVG----YVLLG---TFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETL----VSIKRVQ 382
            |..:|    |||..   ..|||.|||:....:|.||..|.:     ::.:..||    ||.||::
 Worm   489 LVAIGSFTCYVLWSPDENGLTPSVAFVALTIFNQLRQPMRM-----VANLINTLVQARVSNKRLR 548

  Fly   383 KYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISI 447
            :::                             .|||.:...:..||.  |.|.:||.|:..|   
 Worm   549 QFL-----------------------------NDEEMERKTEVALGN--AIVFKNASLNWKG--- 579

  Fly   448 SGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSY 512
                   ..|.|  .|..::..::||.::.|||..|.|||||:.|:|.|:....|.:||.||::|
 Worm   580 -------PQNPP--VLKDLSATIKPGQLIAIVGSVGGGKSSLLSAVLDEMVLLDGRVKVGGSIAY 635

  Fly   513 ASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKAR 577
            ..|..|:|:.|:::|||||..:....|.:||..|.|:.||......:.|:|||.|.:||||||||
 Worm   636 VPQHSWIFNKTIKENILFGNELSNYFYDQVVGSCQLKTDFRHFQQGENTMVGENGITLSGGQKAR 700

  Fly   578 ISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCM--RGYLRERIVILATHQLQFLQHADQIVI 640
            ||||||||::..||||||||||||.||.|.||::.:  .|.||.:..:|.||.||:.::.|.|.:
 Worm   701 ISLARAVYQDKDIYLLDDPLSAVDAHVGRALFDKVIGPDGLLRSKTRVLVTHNLQYTKYVDTIYV 765

  Fly   641 MDKGRVSAVGTYESLRESGLDFASMLADPERDEQ--SEERSRSRSGSY----------------- 686
            ::.|::...|::|.:......|..:.::.|..::  ::|.:.|...|.                 
 Worm   766 IEDGQIVQHGSFEDIAYVDGPFGRLWSECENSDEDVADEEAESSEASVTPPVPVLENGDNGAIEK 830

  Fly   687 ------THSH-SDQRRNSEQSLLSMADSCMDDLEAEQANNQERQEAGQIGLRLYSKYFKAGGGF- 743
                  |:|| |::.|.||:.            ..:...|.|..:.|::...:|..|.|..|.| 
 Worm   831 SSQIDRTNSHFSEKSRKSEEK------------PQKVEKNVENVQLGRVKKSVYQLYIKTMGIFN 883

  Fly   744 ---FAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEE----LEPRLSTWLR 801
               |..|.:..|.|:......|.|:.......||..:: ..|..::|.|.:    :|.||..:..
 Worm   884 SSAFLIFFIAHFTVMIMRSLWLSDWSNENAAIKKATLS-SVDYLNSTSSVDGPVSVETRLIVYAG 947

  Fly   802 DIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNP 866
            ..||.:   :|....|||:|:               .:::||..||:.:...:..|.:.||:|.|
 Worm   948 FGGLEM---LLLALAFTVLTI---------------GSLRASYGLHSPLIHALLVAPISFFDTTP 994

  Fly   867 SGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFY 931
            :|||:||.|:|:..:|::...:.| ..|..|....|:::|::..|:||:....|.:|:|.:..:|
 Worm   995 TGRIINRLSRDLDVIDKLQDNIRM-CTQTLLNACMILVLISISTPIFLVCAAPLILIYYFVMIYY 1058

  Fly   932 LKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRA 996
            :.|||.:||:|:..|||:.|.:|.|:.|.|:||||..............|..:...|:...::|.
 Worm  1059 IPTSRQLKRLESANRSPILSTIAESIHGASSIRAFDKTERTTTALSTNVDKFAQCRYLSHMSNRW 1123

  Fly   997 FGYWLDCF---CVIYIAI-ITLS--FFIFPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTM 1055
            ....|:..   ||::.:: .|||  :|...|   |..||:::.|:.:|.::...:|..:|:|:.:
 Worm  1124 LATRLELLGNTCVLFASLSATLSTKYFGLTP---GMAGLSVSYALTITEVLNICVRSVSEIESNI 1185

  Fly  1056 TAVERVVEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSEN---VLKSLSFVI 1117
            .:||||.||:.:|||.........:..:.||.:|||..|..|:||     .:|   |||::...|
 Worm  1186 VSVERVNEYQKLEPEAPWRIEKSLENEEKWPVKGKIELDGFSMRY-----RKNLPLVLKNIDLKI 1245

  Fly  1118 KPKEKVGIVGRTGAGKSSLINALFRLSYND-GSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSG 1181
            :..|::|::||||:|||||..||:|:...: |::.||..:...:|||.||||:.|||||||:|||
 Worm  1246 EGGERIGVIGRTGSGKSSLTMALYRMIEGESGTIKIDDVEIDTIGLHQLRSKLIIIPQEPVVFSG 1310

  Fly  1182 TMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRE 1246
            |:|:|||||::||||::|..||..:||:...:....|...|.|||.|.|||:|||:||.||:||.
 Worm  1311 TLRFNLDPFNQYSDDQIWNCLEICQLKQFAQEDDKTLDRYIAEGGKNMSVGERQLLCLCRALLRG 1375

  Fly  1247 NRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPY 1311
            .||:::|||||:||..|||::|..||..|.:.|.::|||||.||:|||:::|:||||..||.||.
 Worm  1376 ARIVILDEATASVDTVTDGIVQRAIRQHFPQSTTISIAHRLDTIVDSDRIVVLDAGRVAEFDTPS 1440

  Fly  1312 ELLTLADS 1319
            .||...||
 Worm  1441 NLLLNPDS 1448

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7627NP_001245943.1 CFTR_protein 12..1315 CDD:273530 439/1364 (32%)
ABC_membrane 107..360 CDD:294371 75/259 (29%)
ABCC_MRP_domain1 445..645 CDD:213217 87/201 (43%)
ABC_membrane 815..1014 CDD:294371 57/202 (28%)
ABCC_MRP_domain2 1089..1310 CDD:213211 114/224 (51%)
mrp-8NP_499598.2 CFTR_protein 173..1459 CDD:273530 442/1373 (32%)
ABC_membrane 259..527 CDD:294371 76/272 (28%)
ABCC_MRP_domain1 568..770 CDD:213217 92/213 (43%)
ABC_membrane 887..1168 CDD:294371 83/303 (27%)
ABCC_MRP_domain2 1219..1439 CDD:213211 114/224 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.720

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