DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and pgp-7

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_001361833.1	Gene:	pgp-7 / 188697	WormBaseID:	WBGene00004001	Length:	1152	Species:	Caenorhabditis elegans

Alignment Length:	1305	Identity:	285/1305 - (21%)
Similarity:	478/1305 - (36%)	Gaps:	353/1305 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 EKTKGKPNLLRALLRV-------FGWYFALLGLVLFLLELGL----------------------- 104
            :..:.||..|.:.:||       |..:..|:| |.|.|..||
Worm    15 QSNEKKPLELCSFIRVIFKCTSCFEKFLFLIG-VFFSLVTGLCQPFVSYTLGETAQVLVTITNAI 78

  Fly   105 --RTLQPIFLLKLIAYYTHGSESIESAYYYAAGVILCSALN-VIIMHPYMLGTMHVGLKMRVGMC 166
              :|:.|..|.|....|..|...: ..|::..|   |:... ..|.|..|   .:||......:.
Worm    79 NNKTIDPADLKKAYEQYERGMYQV-VLYFFLCG---CAYFTFASIQHAIM---KYVGDNTTYRVR 136

  Fly   167 SMIYRKALRLSKSALGDTTAGHVVNLMSNDVGRL------DLATIFVHYLWVGPLETLFIT---- 221
            .....:.||.......:.:.||:..::::::.|.      .:|.||.       |.|.|:.
Worm   137 KQYISRLLRKDAEYFDNVSTGHLSTVLNDNLERFREVFNEKIALIFA-------LLTDFVVGTAL 194

  Fly   222 --YLMYR--EIGIAAVFGVAF------------------------MLLFIPLQAYL------GKR 252
              |..:|  ..||....|:||                        .:.|..|.||.      |:.
Worm   195 AFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQN 259

  Fly   253 TSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYI------ 311
            |.:.|....|:..|:.        ||....||:....|.:...    ..:|.:  :.|:
Worm   260 TEIERYTEELKAGEKY--------GIHRALMYSISRGFTYFFC----NSLNTV--ILYVGANMIY 310

  Fly   312 RGILLSFIIFLTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLV 376
            .|.|...::    |.||    .|::.|.|...|....|:.....:.:|         :.:||.|:
Worm   311 SGSLEPAVV----VRIF----HYMMFGAFCLSEALPHISRLAGAISST---------APIAEMLI 358

  Fly   377 SIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLS 441
            ....|   ::.|||: .|:.|:                                   ||.|
Worm   359 KEDNV---IEKDETD-YDVEVE-----------------------------------VNGN---- 380

  Fly   442 EAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKV 506
               ||...:...:........|.|::..||.|..:.:||.:|||||:::|.:|.....:||.|.:
Worm   381 ---ISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFI 442

  Fly   507 NGS-------------MSYASQEPWLFSGTVRQNILFGQP-MDRRRYAKVVKKCALERDFEL-LP 556
            :|.             :...||||.||:.|:.:||.||.| :........::| |...||.. .|
Worm   443 DGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRK-ANAYDFVCSFP 506

  Fly   557 FKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDT---HVARHLFEQCMRGYLR 618
            ...||||||||..||||||.||::||.:.|...|.|||:..||:|.   .|.:...|...:|
Worm   507 KGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQG--- 568

  Fly   619 ERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESL-RESGL--DFASMLADPERDEQSE---- 676
             |..|:..|:|..:::|.:|::|.||.:..||.::.| .:.|:  |..........|:..|
Worm   569 -RTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPL 632

  Fly   677 -ERSRSRSGSYTHSHSDQRRNSEQSLLSMAD--SCMDDLEAEQANNQERQEAGQIGLRLYSKYFK 738
             .|..|:..|..||::.||..|..:.:...|  ..:|:|..|.|.....:|   |..:....|
Worm   633 AARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLRE---IVKQCRPDY-- 692

  Fly   739 AGGGFFAFFVMMG-------FCVLSQ-------GLASLGD---YFLSYWVTKKGNVAYRADNNDT 786
                .|.|..:.|       :.:|:|       |.|.:|:   |:...|...
Worm   693 ----CFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALS------------- 740

  Fly   787 TRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMF 851
                                          |..:.|...|....:.:.|..::.:.|.||....|
Worm   741 ------------------------------FMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSF 775

  Fly   852 RGITRAAMYFFN--TNPSGRILNRFSKDMGQ----VDEILPAVMMDVIQIFLAL--AGIVIVIAV 908
            ..:......|::  .:.:.|:.||.:.|...    ||:.|..|:|.|:.|.:|:  |.:......
Worm   776 SHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMT 840

  Fly   909 VNPLFLIPTVVLGIIFYQLRTFYLKTS--RDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQ-R 970
            :..|...|.:.|....|...|   :||  .|....|...|:.:     .:|..:.|:||...: :
Worm   841 LEVLIFFPLLYLAEYCYDAAT---ETSIQEDTIAFENSNRTAI-----EALENMRTVRALNLEDK 897

  Fly   971 VLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCFCVIYIAIITLSFFIFPPANGGDVGLAITQAM 1035
            ::....::.|.:|.|.|...|....|.|..|.|:..:|........::
Worm   898 IMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCYLFVYSVSFKFGTYL----------------- 945

  Fly  1036 GMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKP-------------PKSWP- 1086
                    .:|:.....:|...:|.:....::....|...|..||.             |.:.|
Worm   946 --------ALRKEVAPMDTYLILETLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPF 1002

  Fly  1087 ---------EQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFR 1142
                     |:|:|:.:.:...|...| ...:|..::..:.|.:.:.:||.:|.|||::|:.|.|
Worm  1003 SSSDGKKNIEKGEIIGENVQFHYDQRP-DRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLER 1066

  Fly  1143 LSYN-DGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVK 1206
            ..:. ||.|.||..:..::.|:.|||.::::.|||.||:.::|.||    .|.   |.||:.:::
Worm  1067 FYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENL----LYG---LTRSVPQLE 1124

  Fly  1207 LKEVV 1211
            |::.:
Worm  1125 LEKAL 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	285/1305 (22%)
		ABC_membrane	107..360	CDD:294371	57/303 (19%)
		ABCC_MRP_domain1	445..645	CDD:213217	74/217 (34%)
		ABC_membrane	815..1014	CDD:294371	46/209 (22%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	37/124 (30%)
pgp-7	NP_001361833.1	MdlB	42..621	CDD:224055	158/675 (23%)
		ABC_MTABC3_MDL1_MDL2	381..618	CDD:213216	80/241 (33%)
		ABC_6TM_Pgp_ABCB1_D2_like	686..994	CDD:350022	64/389 (16%)
		TM helix 1	695..718	CDD:350022	4/22 (18%)
		TM helix 2	733..781	CDD:350022	9/90 (10%)
		TM helix 3	790..835	CDD:350022	13/44 (30%)
		TM helix 4	836..885	CDD:350022	11/56 (20%)
		TM helix 5	897..947	CDD:350022	10/74 (14%)
		TM helix 6	956..989	CDD:350022	6/32 (19%)
		P-loop_NTPase	1019..>1143	CDD:393306	35/119 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000