DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7627 and Abcb1a

DIOPT Version :9

Sequence 1:NP_001245943.1 Gene:CG7627 / 34148 FlyBaseID:FBgn0032026 Length:1355 Species:Drosophila melanogaster
Sequence 2:NP_035206.2 Gene:Abcb1a / 18671 MGIID:97570 Length:1276 Species:Mus musculus


Alignment Length:1414 Identity:307/1414 - (21%)
Similarity:573/1414 - (40%) Gaps:319/1414 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 EKTKGKPNL-LRALLRVFGW---YFALLGLVLFLLE-LGLRTLQPIFLLKLIAYYTHGSESIES- 128
            ||.:.||.: :..:.|..||   .:.|:|.:..::. :.|..:..||.....::.:.|:.|..| 
Mouse    25 EKKEKKPAVSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSKNST 89

  Fly   129 ---------------------AYYY---AAGVILCSALNVII--------MHPYMLGTMHVGLKM 161
                                 ||||   .|||::.:.:.|..        :|.......|..:..
Mouse    90 NMSEADKRAMFAKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQ 154

  Fly   162 RVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVGRLD-------------LATIFVHYL--- 210
            .:|...:               ...|.:...:::||.:::             :||.|..::   
Mouse   155 EIGWFDV---------------HDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGF 204

  Fly   211 ---WVGPLETLFITYLM---------------------YREIGIAAVFGVAFMLLFIPLQAYLGK 251
               |...|..|.|:.::                     |.:.|..|...:|.:...|   |:.|:
Mouse   205 TRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVI---AFGGQ 266

  Fly   252 RTSVLRLRTALRTDERVRMMNEIISGIQV----IKMYA-WELPFEHMVAFARKKEINAIRHVSYI 311
            :..:.|....|...:|:.:...|.:.|.:    :.:|| :.|.|.:..:....||        |.
Mouse   267 KKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKE--------YS 323

  Fly   312 RGILLSFIIFLTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLV 376
            .|.:|         ::|.|    ||:|.|...:.:..|.|:.|.......||      ::.:...
Mouse   324 IGQVL---------TVFFS----VLIGAFSVGQASPNIEAFANARGAAYEVF------KIIDNKP 369

  Fly   377 SIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQ-ETVHADGDEERDEAEDKLLGPPIATVNENAKL 440
            ||....|            |....::.||:.: :.:|......::                    
Mouse   370 SIDSFSK------------SGHKPDNIQGNLEFKNIHFSYPSRKE-------------------- 402

  Fly   441 SEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIK 505
                :.|               |.|:||:|:.|..:.:||.:|.|||:.:|.:........|.:.
Mouse   403 ----VQI---------------LKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVS 448

  Fly   506 VNGS-------------MSYASQEPWLFSGTVRQNILFGQ---PMDRRRYAKVVKKCALERDFEL 554
            ::|.             :...||||.||:.|:.:||.:|:   .||  ...|.||: |...||.:
Mouse   449 IDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMD--EIEKAVKE-ANAYDFIM 510

  Fly   555 -LPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTH---VARHLFEQCMRG 615
             ||.:..|:||||||.||||||.||::|||:.|...|.|||:..||:||.   |.:...::...|
Mouse   511 KLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREG 575

  Fly   616 YLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESL-RESGLDFASMLADPERD--EQSEE 677
                |..|:..|:|..:::||.|...|.|.:...|.::.| ||.|:.|..::.....:  |...|
Mouse   576 ----RTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNE 636

  Fly   678 RSRSR--------SGSYTHSHSDQRRNSEQSLLSMADSCMDDLEAEQANNQERQEAGQIGLRLYS 734
            ..:|:        |...:.|...:||::.:|:....|... .|..::|.:::...|.      :.
Mouse   637 ACKSKDEIDNLDMSSKDSGSSLIRRRSTRKSICGPHDQDR-KLSTKEALDEDVPPAS------FW 694

  Fly   735 KYFKAGGGFFAFFVMMGFC-VLSQGLASLGDYFLSYWV---TKKGNVAYRADNNDTTRSEELEPR 795
            :..|.....:.:||:..|| :::.||........|..|   |..|....:..|::          
Mouse   695 RILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSN---------- 749

  Fly   796 LSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMY 860
                            |.:.:|.::.:::.:....:.|.|.......:.||...:|:.:.|..:.
Mouse   750 ----------------LFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVS 798

  Fly   861 FFN--TNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNP-------LFLIP 916
            :|:  .|.:|.:..|.:.|..||.....:.:..:.| .:|..|..|:|:::..       |.::|
Mouse   799 WFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQ-NIANLGTGIIISLIYGWQLTLLLLAIVP 862

  Fly   917 TV-VLGIIFYQLRTFYLKTSRDVKRMEA----ITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEF 976
            .: :.|::  :::....:..:|.|.:|.    .|.:........|||.........||. |:..:
Mouse   863 IIAIAGVV--EMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQS-LQIPY 924

  Fly   977 DNYQDMHSSAFYMFISTSRAFGYWLDCFCVIYIA-IITLSFFIFPPANGGDVGLAITQAMGMTGM 1040
            .|.. ..:..|.:..|.::|..|:....|..:.| ::|.....|...      |.:..|: :.|.
Mouse   925 RNAM-KKAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENV------LLVFSAI-VFGA 981

  Fly  1041 VQWGM---------RQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDEL 1096
            :..|.         :.:....:.:..:|:..|.:....:|.       ||...   :|.:.|..:
Mouse   982 MAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGL-------KPNML---EGNVQFSGV 1036

  Fly  1097 SLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYND--GSVLIDKRDTSE 1159
            ...| |...|..||:.||..:|..:.:.:||.:|.|||:::..|.|. |:.  |||.:|.::..:
Mouse  1037 VFNY-PTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERF-YDPMAGSVFLDGKEIKQ 1099

  Fly  1160 MGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSD-------DKLWRSLEEVKLKEVVADLPSG 1217
            :.:..||:::.|:.|||:||..::..|:    .|.|       :::.|:.:|..:.:.:..||..
Mouse  1100 LNVQWLRAQLGIVSQEPILFDCSIAENI----AYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDK 1160

  Fly  1218 LQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLT 1282
            ..:::.:.||..|.||:|.:.:|||::|:..||::||||:.:|.:::.::|..:....:..|.:.
Mouse  1161 YNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIV 1225

  Fly  1283 IAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVK-QTG 1330
            |||||.||.::|.::|:..|:..|.||..:|  ||...::..||. |.|
Mouse  1226 IAHRLSTIQNADLIVVIQNGKVKEHGTHQQL--LAQKGIYFSMVSVQAG 1272

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
CG7627NP_001245943.1 CFTR_protein 12..1315 CDD:273530 301/1396 (22%)
ABC_membrane 107..360 CDD:294371 56/330 (17%)
ABCC_MRP_domain1 445..645 CDD:213217 73/219 (33%)
ABC_membrane 815..1014 CDD:294371 39/213 (18%)
ABCC_MRP_domain2 1089..1310 CDD:213211 69/229 (30%)