Protein Alignment CG7627 and mrp-3

DIOPT Version :9

• Sequence 1: NP_001245943.1
• Gene: CG7627 / 34148
• FlyBaseID: FBgn0032026
• Length: 1355
• Species: Drosophila melanogaster
• Sequence 2: NP_001359552.1
• Gene: mrp-3 / 181677
• WormBaseID: WBGene00003409
• Length: 1505
• Species: Caenorhabditis elegans
• Alignment Length: 1411
• Identity: 443/1411 - (31%)
• Similarity: 711/1411 - (50%)
• Gaps: 185/1411 - (13%)

  Fly     2 QSLKTADLPENPREHCNFIS-AACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASW 65
            |:||.      |.|:.|||| ....|:|....: |.:|||...|::....:...|.|..:....|
 Worm   189 QNLKC------PEENANFISRQLLLWFTQIISL-GYERTLVADDVFEMDSQMDQEYLKARWKTEW 246

  Fly    66 ELELEKTKGK-----------------------------------------PNLLRALLRVFGWY 89
            ..:.||.:.|                                         |:::..|.::..|
 Worm   247 LKQTEKAREKQVKLDDKRERARTGSEKAPLLGTFNNYGAVNLDDKDRVIVQPSVIVTLWQIMKW- 310

  Fly    90 FALLG--LVLFLLELGLRTLQPIFLLKLIAYYTHGSESIESAYYYAAGVILCSALNVIIMHPYML 152
             .:||  .:.||.:| |:...|.||..||.:....:..:.:....|.|:.|...:..:.|:.|.:
 Worm   311 -EILGGSFIKFLSDL-LQFANPTFLNYLILFIETPNAPLINGIGLAVGLFLAGQIKSLFMNTYFI 373

  Fly   153 GTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLET 217
            ....||.|::..:...:|.|:|.||.:|..:.|.|.:||::|.||.|..:.|..:...|..|.:.
 Worm   374 AMTRVGAKIQTMLSCAVYEKSLLLSNTARRERTVGEMVNILSIDVDRFRMITPQIQQYWSSPFQI 438

  Fly   218 LFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIK 282
            :....|:.:.||:|...|:..|:..:|:...:...|...:||.....|||:|::||:::||:|:|
 Worm   439 IICMVLLSQTIGVAVWAGIVVMISIVPINICVSMITKRWQLRLMKYKDERIRLINEVLNGIKVVK 503

  Fly   283 MYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFL-TRVSIFLSLVG---YVLLG--TFL 341
            :.|||...|..:...|.||:..|:.    ..:|.:|...| ....:|::|..   :||:.  ..|
 Worm   504 LSAWETAMEETIERVRDKELKMIKQ----SALLKTFADCLNVGAPVFVALSSFTVFVLIDPKNVL 564

  Fly   342 TPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGS 406
            ||.:||:..:.:|:||..: :...:.::|..:.:||.|||:.::...|.:...:..::..:.. :
 Worm   565 TPNIAFVSLSLFNLLRGPL-MMAAELVAQTVQLVVSNKRVRTFLCEKEVDTAAIDKEIRGELY-T 627

  Fly   407 NQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQ 471
            |...:|: |....|.||.::                                    |:.:.....
 Worm   628 NTVEIHS-GSFAWDSAEARI------------------------------------LSDIEFLAG 655

  Fly   472 PGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDR 536
            ...::.:||..|||||||:.|.|||:....|.:.|.||::|.||:||:.:.::::|:|....::.
 Worm   656 SKELVTVVGSVGSGKSSLLLAALGEMEKVCGYVGVRGSVAYLSQQPWILNQSLKKNVLMQADLND 720

  Fly   537 RRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVD 601
            ..|.||::.|||:.|.:.||..|.|.:||:|.:|||||||||:||||||:...:|.|||||||||
 Worm   721 VLYKKVIESCALKEDLKQLPDGDDTEIGEKGINLSGGQKARIALARAVYQSKDVYFLDDPLSAVD 785

  Fly   602 THVARHLFEQCM--RGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTY----------ES 654
            .||.:|:|:..:  .|.|.....||.|:...|||.:.:|::|..||:...|||          |.
 Worm   786 AHVGKHIFDNVIGPNGMLSHTTRILVTNCTSFLQESGKIIVMKDGRIKHCGTYNELLTDVEAREY 850

  Fly   655 LRESGLDFASMLADPERDEQSEERSRSRSGSYTHSHSDQRRNSEQSLLSMADSCMDDLEAEQAN- 718
            |:|...::|........:...||.|....||.. |.|...|.|..|.:|...|....:|.::.:
 Worm   851 LQEVDNEYAQAQESSGEESGGEENSDILPGSIA-SGSRMSRLSRLSKISRKKSKSSIVEKKKPDA 914

  Fly   719 --NQERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRA 781
              .:|....|::...:|..|||| .|...:.:.....|:.....:||   .|.|:|...:.....
 Worm   915 LITKEEAAIGRVNPGVYLLYFKA-MGIVTYVLPYAIAVVLNVSFALG---RSLWLTAWSDANIDI 975

  Fly   782 DNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYI-FTVITVLTILVTVARSFLFFNLAM----- 840
            ::.||                  :||.|. |..|. |.:..|:         ||||:|.:
 Worm   976 NHPDT------------------MSVGAR-LGVYAGFGITEVI---------FLFFSLVLLLIGG 1012

  Fly   841 -KASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVI 904
             .||..||..:...:.|..:.:|:..|.|||:||.:|||..||..|.:....::...:.:...|:
 Worm  1013 VAASKNLHKPLLHNVLRNPLSYFDITPIGRIINRLAKDMEVVDLRLSSSFRFLVMALINMVQTVL 1077

  Fly   905 VIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQ 969
            :::...|||:...:.:.||::.:..:.:|::|.::|:.::||||::|:.:.:|.|:||:|||...
 Worm  1078 IVSYTTPLFIAIIIPVFIIYFFVLKYSIKSTRQLQRIASLTRSPIFSNFSETLQGISTVRAFQWS 1142

  Fly   970 RVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLD----------CFCVIYIAIITLSFFIFPPANG 1024
            .......|.:.:.|....|.    |:....||.          .|....:|||.....|    ..
 Worm  1143 DEFVRRNDEHLNTHVKCSYY----SQMANRWLSIRLELLGNIVIFSAAILAIIGKESGI----TA 1199

  Fly  1025 GDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDI--EPEGALEAPADKKPPKSWPE 1087
            |.:||:::.::.:|.|:...:||..|:|..:.:|||:.||...  |.|..|:   :...|.:||.
 Worm  1200 GMLGLSVSYSLNITFMLNMFVRQINEVETNVVSVERIDEYSKTKSEAEWRLD---NNNLPSNWPT 1261

  Fly  1088 QGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVL 1151
            .|.:..::.|.||..:  .:.|||.:|..|.|.:|||:.||||||||||..||||: ...||::.
 Worm  1262 GGAVNIEDYSCRYRDE--LDLVLKQISLNILPGQKVGVCGRTGAGKSSLALALFRIVEAADGNIS 1324

  Fly  1152 IDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPS 1216
            ||:..||.:||||||.|::|||||.|||:.|:|:|:||..:::|.:||.:||...||..|..||.
 Worm  1325 IDQTITSHIGLHDLREKLTIIPQENVLFANTLRFNIDPKGQFTDQQLWLALENSNLKAHVELLPH 1389

  Fly  1217 GLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVL 1281
            .|:|.:.|||.|||||||||:||.||:||::::||:|||||.:|.:||.::|.|||.||.:.|::
 Worm  1390 KLESPVAEGGENFSVGQRQLLCLTRALLRKSKVLVLDEATAGIDNRTDTMVQATIREKFADSTII 1454

  Fly  1282 TIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVK 1327
            |||||||||:|.|:::||||||.||.|.|.|||...:|: |:|:.|
 Worm  1455 TIAHRLHTIIDYDRIIVMDAGRIVEDGIPGELLKNRNSQ-FYGLAK 1499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	435/1387 (31%)
		ABC_membrane	107..360	CDD:294371	73/258 (28%)
		ABCC_MRP_domain1	445..645	CDD:213217	78/201 (39%)
		ABC_membrane	815..1014	CDD:294371	57/215 (27%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	120/221 (54%)
mrp-3	NP_001359552.1	MRP_assoc_pro	25..1501	CDD:188098	443/1411 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I5384
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720