DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and mrp-5

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_510479.1	Gene:	mrp-5 / 181587	WormBaseID:	WBGene00003411	Length:	1427	Species:	Caenorhabditis elegans

Alignment Length:	1349	Identity:	439/1349 - (32%)
Similarity:	698/1349 - (51%)	Gaps:	137/1349 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 WELELEKTKGKPNLLRALLRVFG---WYFALLGLVLFLLELGLRTLQP-IFLLKLIAYYTHGSES 125
            ||.|.:.....|:|.:.:.|...   |:..  .:..|.|..|.  :.| .|:.:|||:..:....
Worm   121 WEDEKKANAKSPSLFKVIYRFISTRLWFSC--AVFFFCLIFGF--IGPTCFIRRLIAFAENPERD 181

  Fly   126 IESAYYYAAGVILCSALNVI-IMHPYMLG-----TMHVGLKMRVGMCSMIYRKALRLSKSALGDT 184
            .:|...|:.|:.|.:|::|: .......|     :...|:::|..:.:::|:..|. ||...|.|
Worm   182 EQSRIVYSYGIALVAAISVVEFARVLSYGATWAVSYRTGIRVRGAVLALLYKNVLN-SKDLCGKT 245

  Fly   185 TAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETL-FITYLMYREIGIAAVFGVAFMLLFIPLQAY 248
            .: .|:|:.:||..||..|..|...:.||||..: .|.||: ..||..::.|:....:|..:|..
Worm   246 ES-DVINIFANDGQRLFDAVTFAPLVLVGPLVLVGGIGYLL-MVIGRWSLLGILVFFVFDVIQFG 308

  Fly   249 LGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRG 313
            |||.....|....::|::|:.||.|||..|:::||..||..|...:...||:|...||...|.:.
Worm   309 LGKSMVACRNLAIVKTEKRISMMAEIIKYIRIVKMNGWEQIFSAKIDQFRKEEKVQIRKSGYAQS 373

  Fly   314 ILLSFIIFLTRVSIFLSLVGYVLLGTFLTPEVAF-LITAYYNILRTTMTVFFPQGISQMAETLVS 377
            :.::....:..|:..|:.||.||.|..|....|| .||.|:.:|.....:  |.|...:||.:|:
Worm   374 LAIACGPVVPVVAAILTFVGVVLAGNDLLASDAFSAITVYFVMLFGIRMI--PYGSRYLAEAVVA 436

  Fly   378 IKRVQKYMQSDE------TNVMDMSVDLTEDFQGS----NQETVHADGDEERDEAEDKLLGPPIA 432
            ::|:|:|:..::      ||..|:.:|.    ||:    ..:...|..||.::..|::::
Worm   437 MRRIQEYLLLEQYAPYPVTNAEDVVLDC----QGATYTYQPKAAKAPVDETKEPTENEVI----- 492

  Fly   433 TVNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGEL 497
                                  .|.:|.::.:...|.::.|..:.::|..|.|||::::||.|.:
Worm   493 ----------------------VVETPVFTCSFDKLSIKRGEHIAVIGAVGCGKSAILKAISGHM 535

  Fly   498 PAESGEIKVNGSMS-YASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKT 561
            ......:.|:.|.: |..|:.|:|:|||:.|||||..|:..||.|.|..|.|..|...|...|:|
Worm   536 FTTDDALSVDRSQTVYVPQKAWIFNGTVQDNILFGDKMNSERYYKAVNGCQLTEDLTTLSVGDRT 600

  Fly   562 IVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILAT 626
            .||||||:||||||||::|||||::..::||.||..:::|..||..:.|:.::..|:::.:::.|
Worm   601 EVGERGATLSGGQKARVALARAVFQTKNLYLFDDIFASLDKKVANKIHEEIIQKLLKKKALMMVT 665

  Fly   627 HQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLDFASMLADPERDEQSEERSRSRSGSYTHS-- 689
            :.::.|.|.|:::.::.|.:.|.|.::.|.|.. |......|.....|:...:.|..|.....
Worm   666 NNMELLHHFDRVLFVEGGNIVADGNHDILYEKN-DAYKTFVDACETYQATSGATSPCGDGPAQPA 729

  Fly   690 --HSDQRRNSEQSLLSMADSCMDDLEAEQANNQERQEAGQIGLRLYSKYFKAGGGFFAF-FVMMG 751
              .::..|||.:.|...||..:.| |.:..|:       .|..|:|.:|..|.||:..: .:::|
Worm   730 PLDAEILRNSSEDLKGDADKLISD-EEDMGNS-------TIAWRIYKQYIHAAGGWPIWTCLVIG 786

  Fly   752 FCVLSQGLASLGDYFLSYWVT---KKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLD 813
            |.|     ..:.:.|.:||::   |||:.......|.|   |.||.:.|.        .|:.:..
Worm   787 FIV-----NVVSNIFSTYWLSRWLKKGHDETTTITNGT---EFLEMKTSL--------ADSPVTG 835

  Fly   814 TYIFTVITVLTILVTVARSF---LFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFS 875
            .|....:..|.:| |::..|   :|..:::.|:.|||:.||:.:...|..||::.|:||||||||
Worm   836 FYAAVYLVALVVL-TISGLFKACVFVKVSLTAATRLHDRMFQAVIHGATSFFDSTPTGRILNRFS 899

  Fly   876 KDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKR 940
            |||.::|..||......:|..:...|.::||..|.|.||:..:.|.::|....:.:....|::||
Worm   900 KDMDEIDVKLPFTAEVFLQNMITCLGFLVVITSVFPYFLLFAIPLFVVFVVFVSCFRAGIRNLKR 964

  Fly   941 MEAITRSPVYSHLAASLTGLSTIRAF-GAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCF 1004
            .|.|:|||:|.|::|||.|::||..| .:.|.||. ...:.|.:|.|.:||.|..|....|||..
Worm   965 SEHISRSPLYDHVSASLEGITTIHTFQQSNRFLEV-LKKHLDCNSGAIFMFQSAMRWLAVWLDLL 1028

  Fly  1005 CVIYIAIIT-LSFFIFPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIE 1068
            .|:..||:. |:..:....:..|.|:||..|:.|:|:.|:.:|...|||..||:||||..|.|..
Worm  1029 VVVMTAIVALLTVMLTGTVSPADAGMAIAFAVQMSGIFQFAVRTQTELEAKMTSVERVSYYADNI 1093

  Fly  1069 PE-GALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENV-LKSLSFVIKPKEKVGIVGRTGA 1131
            || |............|||..|:|.|.|::|||.   ||..: |..::|.||..|||||:||||:
Worm  1094 PEDGEWNTRQGLDIESSWPANGQINFSEVNLRYR---KSHPLALNDITFEIKGGEKVGIIGRTGS 1155

  Fly  1132 GKSSLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSD 1195
            |||||.|.:||| ...:|::.||..|...:||..||..||.|.|:|.|||||:|:||||..||||
Worm  1156 GKSSLANLIFRLYPVTNGTIYIDGVDIRTVGLVKLRRGISAIAQDPSLFSGTVRFNLDPSLEYSD 1220

  Fly  1196 DKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVD 1260
            ..:|.:||:..||.:|..|...|::.::.||.|||||:|||.|||||:|.::||:::|||||:||
Worm  1221 SMIWEALEKCHLKTLVQSLDKKLEADVSHGGNNFSVGERQLFCLARALLMKSRIVILDEATASVD 1285

  Fly  1261 PQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVF--- 1322
            ..||.|||..|:..|.:.||:.|||||..:.:.|:::.:..|:.:.|.||.|:.. .|..|:
Worm  1286 AGTDKLIQEVIKTVFADATVIIIAHRLDNVRNMDRIMHLKNGKLINFTTPQEMFK-DDWSVYKLE 1349

  Fly  1323 -----------------HGMVKQTGHATYES--LLKIAQKAFENRQNHS 1352
                             |.|.|.:..::.||  ::|:     ||.|..|
Worm  1350 DKDDDQHSAVVVGENSEHSMEKSSQGSSQESDDIVKV-----ENEQKDS 1393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	427/1288 (33%)
		ABC_membrane	107..360	CDD:294371	77/261 (30%)
		ABCC_MRP_domain1	445..645	CDD:213217	69/200 (35%)
		ABC_membrane	815..1014	CDD:294371	73/203 (36%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	108/222 (49%)
mrp-5	NP_510479.1	MRP_assoc_pro	90..1340	CDD:188098	427/1288 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	142	1.000	Domainoid score	I2904
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830