DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7627 and pgp-4

DIOPT Version :9

Sequence 1:NP_001245943.1 Gene:CG7627 / 34148 FlyBaseID:FBgn0032026 Length:1355 Species:Drosophila melanogaster
Sequence 2:NP_001257142.1 Gene:pgp-4 / 181327 WormBaseID:WBGene00003998 Length:1280 Species:Caenorhabditis elegans


Alignment Length:1439 Identity:337/1439 - (23%)
Similarity:574/1439 - (39%) Gaps:352/1439 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 ASWELEL----EKTKGKP-----NLLRALLRVFGW--YFALL-GLVLFLLELGLRTLQPIF---- 111
            ||..:||    :|.|.|.     |.|..|.|..|.  |..|| ||||......|.....:.    
 Worm    18 ASEHVELGSRPDKKKKKSRSSQGNSLSNLFRHSGCADYLLLLGGLVLSAANGALLPFNSLIFEGI 82

  Fly   112 ---LLKLIAYYTHGSESIES---------AYYYAAGVIL--CSALNVIIMHPYMLGTMHVGLKMR 162
               |:|..|.:.:|:...::         ..|:..||::  |:         |........:..|
 Worm    83 TNVLMKGEAQWQNGTFDYDTFSSGIQHYCLLYFLLGVLMFTCT---------YFSNACLFTMAER 138

  Fly   163 VGMC--SMIYRKALRLSKSALGDTTAGHVVNLMSNDVGRL-----DLATIFVHYLWVGPLETLFI 220
            ...|  ..:.:..||.......:.|.|.:...||:.:.::     |.         :|.|.:...
 Worm   139 RLYCIRKHLLQSVLRQDAKWFDENTVGGLTQKMSSGIEKIKDGIGDK---------IGVLVSGIA 194

  Fly   221 TYLMYREIGIAAVFGVAF-----MLLFIPLQAYLGKR-TSVLRLRTALRTDERV-----RMMNEI 274
            |::.    |:|..|.:.:     ||:.:|||  ||.. .|...|..|.:.:...     .|.||:
 Worm   195 TFIS----GVALGFYMCWQLTLVMLVTVPLQ--LGSMYLSAKHLNRATKNEMSAYSSAGGMANEV 253

  Fly   275 ISGIQVIKMYAWELPFE-----HMVAFARKKEINAIRHVSYIRGILLSFIIFLTRVSIFLSLVGY 334
            |:||:.:..:..: |||     ..:|.|||..|.        :.|:|:....:....:|:.:.|.
 Worm   254 IAGIRTVIAFNAQ-PFEIERYGAQLAKARKMGIR--------KAIVLALCSAMPLFLMFVLMAGA 309

  Fly   335 VLLGTFLTPEVAFLITAYYNILR--TTMTVFFP--QGISQMAETLVSIKRV--QKYMQSDETNVM 393
            ...|..||.         |.:..  ||..||:.  .|..::.|....:..:  .:...:|...|:
 Worm   310 FWYGAILTS---------YGVATSGTTFGVFWAVILGTRRLGEAAPHMGAITGARLAVNDIFKVI 365

  Fly   394 DMSVDLTEDFQGSNQETVHADGDEER--DEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDV 456
            |            ::..::....|.|  |:...||       |.:|.:.:..             
 Worm   366 D------------HEPEINCTKQEGRRPDKVNGKL-------VFDNIQFTYP------------- 398

  Fly   457 NSPDYS-LNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNG------------ 508
            ..||.. |.||:..|.||..:.:||.:|.|||:.|..::......:|.||::|            
 Worm   399 TRPDVKILKGVSFEVNPGETIALVGHSGCGKSTSIGLLMRFYNQCAGSIKLDGIPIEDYNIQWLR 463

  Fly   509 -SMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDF-ELLPFKDKTIVGERGASLS 571
             ::....|||.:|..||.:|:..|......:..:...:.|...|| ..|.....|::|.....||
 Worm   464 STIGIVQQEPIIFLATVAENVRMGDDSITDKDIENACRQANAHDFIGKLSEGYNTVIGAGAVQLS 528

  Fly   572 GGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHL---FEQCMRGYLRERIVILATHQLQFLQ 633
            ||||.|:::|||:.|:..|.|||:..||:||...|.:   .::...|    |..:...|:|..::
 Worm   529 GGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEG----RTTLCIAHRLSTIR 589

  Fly   634 HADQIVIMDKGRVSAVGTYESL-RESGLDFASMLADPE-----------RDEQSEERSRSRSGSY 686
            :|.:|::.|:|.:...|.::.| |::|: :|:|:...|           .||..||.:.|.|...
 Worm   590 NASKILVFDQGLIPERGIHDQLIRQNGI-YANMVRAQEIEKAKDDTTQDDDELVEEDNYSISRRL 653

  Fly   687 THSHSDQRRNS---------EQSLLSMADSCMDDLEAEQAN----NQERQEAGQIGLRLYSKYFK 738
            :.|..:.|::.         .||:||:. |.:.|.|.|.|.    .:...||..:.:..::|..|
 Worm   654 STSEEELRKSKSLLRDSTRFSQSMLSVT-SQVPDWEMESAREEMIEEGAMEASMMDIFRFAKPEK 717

  Fly   739 ------------AGGGFFAFFVMMG--FCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRS 789
                        .|..:.||.|:.|  |.|.::|    |:                         
 Worm   718 MNIVIALIFTLIRGITWPAFSVVYGQLFKVFAEG----GE------------------------- 753

  Fly   790 EELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGI 854
                          .|.|:| ::.:..|.::.|.:.:.|.....|........|.||...:|:.|
 Worm   754 --------------DLPVNA-LISSLWFVLLAVTSAVTTFISGSLLGKTGETMSSRLRMDVFKNI 803

  Fly   855 TRA-AMYFFNTNPS-GRILNRFSKD----MGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLF 913
            .:. |.||.:...: |.:.:|.:.|    ...:|..|..|:..|:.:|..:|........:.|:.
 Worm   804 MQQDATYFDDPKHNVGNLTSRLATDSQNVQAAIDHRLAEVLNGVVSLFTGIAVAFWFGWSMAPIG 868

  Fly   914 LIPTVVLGIIFYQLRTFYLKTSRDVKRME-AITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFD 977
            || |.:|.:|.......||| .|..|.|| ||..|.:   :..|::...|::|...|..:     
 Worm   869 LI-TALLLVIAQSAVAQYLK-YRGPKDMESAIEASRI---VTESISNWKTVQALTKQEYM----- 923

  Fly   978 NYQDMHSSAFYMFISTS-----RAF--GYW------------LDCFCVIYIAIITLSFFIFPPAN 1023
                     |:.|.:.|     |||  |.|            |..|.:.|:      |.::..:|
 Worm   924 ---------FHAFTAASKNPRKRAFTKGLWQSLSFALAGSFFLWNFAIAYM------FGLWLISN 973

  Fly  1024 GGDVGLAITQ---AMGMTGM----------------VQWG-----MRQSAELENT-MTAVERVVE 1063
            ......|:.|   |:.|..|                :..|     :||.|:::|. :|.     |
 Worm   974 NWTTPFAVFQVIEALNMASMSVMMAASYFPEYVRARISAGIMFTMIRQKAKIDNRGLTG-----E 1033

  Fly  1064 YEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGR 1128
            ..||                    :|.|....:...| |:...:.:|.:.:...:..|.|.:||.
 Worm  1034 TPDI--------------------RGDISMKGVYFAY-PNRNRQLILNNFNMSAQFGETVALVGP 1077

  Fly  1129 TGAGKSSLINALFRLSYND---GSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLD-P 1189
            :|.|||:.|..:.|  |.|   |:|.||..|..::.:..||..|:::.|||.||:.|:|.|:. .
 Worm  1078 SGCGKSTSIQLIER--YYDAICGAVKIDDHDIRDISVKHLRHNIALVGQEPTLFNLTIRENITYG 1140

  Fly  1190 FDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDE 1254
            .:..|.:::.::.....:...|.:||.|..:.:...|...|.||:|.:.:||||:|..:||::||
 Worm  1141 LENVSQEQVEKAATLANIHSFVENLPEGYDTSVGASGGRLSGGQKQRIAIARAIVRNPKILLLDE 1205

  Fly  1255 ATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADS 1319
            ||:.:|.:::.::|..:.......|.:.|||||.||.::||::|...|:|:|.||...|  ||..
 Worm  1206 ATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTL--LARR 1268

  Fly  1320 KVFHGMVKQ 1328
            .:::.:|::
 Worm  1269 GLYYRLVEK 1277

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7627NP_001245943.1 CFTR_protein 12..1315 CDD:273530 334/1424 (23%)
ABC_membrane 107..360 CDD:294371 57/295 (19%)
ABCC_MRP_domain1 445..645 CDD:213217 60/217 (28%)
ABC_membrane 815..1014 CDD:294371 52/224 (23%)
ABCC_MRP_domain2 1089..1310 CDD:213211 71/224 (32%)
pgp-4NP_001257142.1 ABC_membrane 65..338 CDD:279056 61/314 (19%)
PTZ00265 68..1276 CDD:240339 317/1386 (23%)
ABC_MTABC3_MDL1_MDL2 389..625 CDD:213216 69/253 (27%)
ABC_membrane 724..993 CDD:279056 70/337 (21%)
ABC_MTABC3_MDL1_MDL2 1041..1278 CDD:213216 75/242 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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