Protein Alignment CG7627 and pgp-8

DIOPT Version :9

• Sequence 1: NP_001245943.1
• Gene: CG7627 / 34148
• FlyBaseID: FBgn0032026
• Length: 1355
• Species: Drosophila melanogaster
• Sequence 2: NP_509811.2
• Gene: pgp-8 / 181277
• WormBaseID: WBGene00004002
• Length: 1243
• Species: Caenorhabditis elegans
• Alignment Length: 1392
• Identity: 308/1392 - (22%)
• Similarity: 546/1392 - (39%)
• Gaps: 373/1392 - (26%)

  Fly    98 FLLELGLRTLQPIFLLKLIAYYTHGSESIESAYYYAAGVILCSALNVIIMHPYMLG--------- 153
            ||..:|:.:.....|.:....||.|..|       .|.|.:.:|:|...:.|..|.
 Worm    38 FLFVIGVVSAICTGLTQPFMSYTFGEVS-------QAFVRITAAVNNASLDPSDLEKAYEMFHAD 95

  Fly   154 ----TMHVGLKMRVGMCSMIYRKALRLSK-SALGDTTA-----GHVVNLMSNDVGRLDLATIFVH 208
                .:|.||   || |:.::...::.|. ..:||.|.     ..::.|:..|....|  ||...
 Worm    96 MNNVVIHFGL---VG-CAFMFFGFIQFSLFKYIGDNTTYRLRHKFILRLLKKDAKYFD--TISTG 154

  Fly   209 YLWVGPLETLFITYL-MYRE-----------------IGIAAVFGVAFMLL-FIPLQAYLGKRTS 254
            |     |.|:....| .:||                 ||.|..|..::.|. :..:.|:....:.
 Worm   155 Y-----LSTVLNDNLERFREAFNEKIAFIICFSTDFAIGTALAFYTSWTLASYGSVFAFGIVISG 214

  Fly   255 VLRLRTALRTDERVRM---------------MNEIIS---GIQVIKMYAWELPFEHMVAFARKKE 301
            :|...:.::::|:..|               ...:||   ..|.::.|:.||.........|...
 Worm   215 LLNSTSMMKSNEKQSMHYSNAGAIAFQALCSFKTVISLNGQTQELEKYSAELKEGEKFGSRRAFF 279

  Fly   302 INAIRHVSY-----IRGILL---SFIIF---LTRVSIFLSLVGYVLLGTFLTPEVAFLITAY-YN 354
            :...|.:|:     :.|.:|   :.:|:   :..|:| ::|..|:|...|...| |||..:| .|
 Worm   280 LATSRGLSHFFCNALNGTILYVGADLIYNKTMNTVAI-VTLFHYMLFSAFSLGE-AFLHISYLLN 342

  Fly   355 ILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEER 419
            .:.:...:|                           :|:....|:.|    :||:....|.::
 Worm   343 AINSATPIF---------------------------DVLTSDDDMIE----NNQDNEQTDSNK-- 374

  Fly   420 DEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDV-----NSPDYS-LNGVNLRVQPGTMLGI 478
                                      :|.|:::..:|     :.||.. |.|::..|:.|..:.:
 Worm   375 --------------------------TIQGMLSFNNVKFAYPSRPDVDILRGISFDVKQGECIAL 413

  Fly   479 VGRTGSGKSSLIQAILGELPAESGEIKVNGS-------------MSYASQEPWLFSGTVRQNILF 530
            ||.:|||||:::|.:|.....:||.||:..|             :...||||.||:.|:.:||.|
 Worm   414 VGASGSGKSTIVQLLLHFYNIQSGTIKIGDSHLHDINLKQLRNAIGVVSQEPVLFNTTIEENIRF 478

  Fly   531 GQPMDRRRYAKVVKKCALERDFELLPFKD--KTIVGERGASLSGGQKARISLARAVYRETSIYLL 593
            |.|...........:.|...|| :...||  |||||||||.||||||.||::||.:.:..:|.||
 Worm   479 GNPNATSSEIYEALRKANAYDF-VCNIKDGLKTIVGERGAQLSGGQKQRIAIARVLVKNPAILLL 542

  Fly   594 DDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRES 658
            |:..||:|: .:....:..::.....|..|:..|:|..::|.|:|::|..|:::.||::|.|...
 Worm   543 DEATSALDS-ASERAVQLALKKASEGRTTIIIAHRLSTIRHCDKIMVMSNGKIAEVGSHEELISM 606

  Fly   659 GLDFASMLADPERDEQS-EERSRSRSGSYTHSHSDQRRNSEQSLLSMADSCMDDLEAE----QAN 718
            ..::::::.....|.|| ||....:........:....|..:.|..:......|:|.:    :..
 Worm   607 DREYSNLVRAQFFDSQSVEEDINGQGAEEVIQKTPPNLNDGEPLEELLKETSSDIEIKSNIWEVL 671

  Fly   719 NQERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRADN 783
            .:.|.:|..:.:.:.....:.          ..|.:|||.:..                .|:|
 Worm   672 RECRPDAFLLSMAVIGSAIQG----------CNFPILSQIIVQ----------------TYKA-- 708

  Fly   784 NDTTRSEELEPRLSTWLRDIGLSVDAEMLDTY------IFTVITVLTILVTVARSFLFFNLAMKA 842
                                 .::|.|.:.||      :|.|:.|:..:....:.|.|..::.|.
 Worm   709 ---------------------YAMDGENILTYGHFWAAMFLVLGVIRPITLYCQFFFFGKVSEKL 752

  Fly   843 SIRLHNSMFRGITRAAMYFFNT---NPSGRILNRFSKD----MGQVDEILPAVMMDVIQIFLALA 900
            |.||....|:.:......|::.   :|: |::||.:.|    ...||..|.:::|.::...||
 Worm   753 STRLRIKSFQHLLSLPCAFYDDPKHSPT-RLVNRLNTDPSNIKAAVDARLGSLLMSMVSFSLA-- 814

  Fly   901 GIVIVIAVVNPLFLIPTVVLGI-IFYQLRTFYLKTS-------------------------RDVK 939
               |:||......|...|||.. :.|..:..|.||:                         :.||
 Worm   815 ---ILIACYYSWKLTLQVVLFFPVLYYAKFLYKKTTTISIKEDSVAFENSNKIAIEVLDNMKTVK 876

  Fly   940 --RMEAITRSPVYSHLAASLT---------GLSTIRAFGAQRVLEA---EFDNY---------QD 981
              .|||...:.|..:||...|         ||:...:.|..:::.|   :|..|         .|
 Worm   877 ALNMEARVINLVMEYLAVLKTSYPRRSVVMGLANGFSAGCSQIVYAISFKFGTYLILQKEVIPMD 941

  Fly   982 MHSSAF---YMFISTSRAFGYWLDCFCVIYIAIITLSFFIFP---PANGGDVGLAITQAMGMTGM 1040
            |:.|..   |.......|..|..|....|:.|.:..:.|.:|   |.|......:||
 Worm   942 MYLSLITLSYTSNMAGSAISYMPDFRKAIHSAGLIFNLFTYPATMPFNSDTGSRSIT-------- 998

  Fly  1041 VQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPK 1105
                                                           :|::..:.:...|...|
 Worm   999 -----------------------------------------------KGEVNGENVKFHYHQRP- 1015

  Fly  1106 SENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSY--NDGSVLIDKRDTSEMGLHDLRSK 1168
            ...||.|::..::..:.:.|||.:|:|||::| :|..:.|  :.|.:.||..:...:.|..|||.
 Worm  1016 DYTVLDSVNLKVEAGKTLAIVGPSGSGKSTII-SLLEMFYRADQGFIKIDNDNVENINLDHLRSN 1079

  Fly  1169 ISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEV---------VADLPSGLQSKITE 1224
            :.::.|.||||:.::|.|:    .|.   |.|::.:.:::..         |..||.||.:.:.:
 Worm  1080 LGLVSQGPVLFNCSIRDNI----LYG---LTRNISQTEIENALQIANAFNFVFQLPQGLDTIVGD 1137

  Fly  1225 GGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHT 1289
            .|...|.||:|.:.:.|||||..::|::||||:.:|.:::.::|..:....:..:.:.:||||.|
 Worm  1138 RGAQLSGGQKQRIAITRAILRNPKLLLLDEATSALDTESEKIVQNALDTASERLSTIVVAHRLST 1202

  Fly  1290 IMDSDKVLVMDAGRAVEFGTPYELLTL 1316
            |:::|.:.|:..|:.||.||..:||.:
 Worm  1203 IINADSIAVLRNGKVVEQGTHNQLLAV 1229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	307/1389 (22%)
		ABC_membrane	107..360	CDD:294371	65/320 (20%)
		ABCC_MRP_domain1	445..645	CDD:213217	74/220 (34%)
		ABC_membrane	815..1014	CDD:294371	58/263 (22%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	67/231 (29%)
pgp-8	NP_509811.2	PTZ00265	29..1241	CDD:240339	308/1392 (22%)
		ABC_membrane	44..326	CDD:294371	58/300 (19%)
		ABC_MTABC3_MDL1_MDL2	382..617	CDD:213216	77/236 (33%)
		ABC_membrane	685..953	CDD:279056	62/322 (19%)
		ABC_MTABC3_MDL1_MDL2	1005..1240	CDD:213216	69/234 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000