Protein Alignment CG7627 and pgp-5

DIOPT Version :9

• Sequence 1: NP_001245943.1
• Gene: CG7627 / 34148
• FlyBaseID: FBgn0032026
• Length: 1355
• Species: Drosophila melanogaster
• Sequence 2: NP_001257116.1
• Gene: pgp-5 / 181276
• WormBaseID: WBGene00003999
• Length: 1252
• Species: Caenorhabditis elegans
• Alignment Length: 1362
• Identity: 313/1362 - (22%)
• Similarity: 540/1362 - (39%)
• Gaps: 335/1362 - (24%)

  Fly    99 LLELGLRTLQPIFLLKLIAYYTHGSESIESAYYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRV 163
            |.|..:..:..:|.|...||:|.|                  .|...||       ..||.....
 Worm    88 LFESDMNRVVLLFFLVGFAYFTFG------------------FLQFSIM-------KFVGDNTAY 127

  Fly   164 GMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVGR------------LDLATIFVHYLWVGPLE 216
            .:......:.||...|.....:.||:..::::::.|            :.|.|.||       :.
 Worm   128 NVRRQYISRLLRKDISYFDGMSTGHLSIVLNDNMERFREVFNEKIALIIALLTDFV-------IG 185

  Fly   217 TLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGI--- 278
            |:...|..:|......||  :|.::...|....||          ::.:|:   .||.||..
 Worm   186 TILAFYTDWRLACYGTVF--SFGIVLSGLLDSWGK----------MKNNEK---QNEHISNAGSI 235

  Fly   279 ------------------QVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIF---- 321
                              |.::.|..||......|..|....:..|...|.....|:|:|.
 Worm   236 AFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFSLSRSADYFFTNALNFVILYFGA 300

  Fly   322 ------LTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKR 380
                  .....:.:.::.|:|.|::...|....|:...:.:..|:.:         |:.|
 Worm   301 NMIYEGTIEPGVVVRILYYILFGSYCLGEAILHISRLASAIPLTVPI---------ADIL----- 351

  Fly   381 VQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGI 445
                :.||.|.....|.::.:.|||.                                      |
 Worm   352 ----LDSDATADEFFSEEIKDTFQGI--------------------------------------I 374

  Fly   446 SISGLMAKWDVNSPDYS-LNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNG- 508
            |...::..:... ||.. |..::..||.|..:.:||.:|||||::||.:|.....:||.|.::|
 Worm   375 SFKNVLFSYPTR-PDVPVLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGN 438

  Fly   509 ------------SMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKD-- 559
                        :|....|||.||:.::.:||.||:|....:......|.|...|| :..|.|
 Worm   439 DIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDF-VCNFPDGI 502

  Fly   560 KTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVIL 624
            |||||||||.||||||.||::||.:.|...|.|||:..||:|.. :..:.::.::.....|..|:
 Worm   503 KTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNE-SEFIVQEALQKASIGRTTIV 566

  Fly   625 ATHQLQFLQHADQIVIMDKGRVSAV----------GTYESLRESGLDFASMLADPERDEQSEERS 679
            ..|:|..:::|::|::|:||.:..|          |.|.:|.::.|    |..:.|:..::|||.
 Worm   567 VAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYNNLVQTQL----MSTNYEKMNENEERV 627

  Fly   680 RSRSGSYTHSHSDQRRN--SEQSLLSMADSCMDDLEAEQANNQERQEAGQIGLRLYSKYFKAGGG 742
            ..:|     ||||...|  |.|. :...|..:..|.||    .:.:.|.:..:....||.::
 Worm   628 TRQS-----SHSDFPSNEISHQK-IDQEDDYVKKLIAE----IKEEGAKKSNICEIIKYCRS--- 679

  Fly   743 FFAFFVMMGFCVLSQGLASLGD------YFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLR 801
                    .:|:|.  :|.||.      |.||..:..|...||..|.:
 Worm   680 --------EYCILF--IAVLGSAIQGIYYPLSSQLMIKSYEAYAFDKD----------------- 717

  Fly   802 DIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFF------NLAMKASIRLHNSMFRGITRAAMY 860
                    |||....|..:::|.:..| ...|:||      ..|.|.||:|.:..|:.:......
 Worm   718 --------EMLSKSHFWALSILFLAFT-RPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCA 773

  Fly   861 FFN--TNPSGRILNRFSKDMGQ----VDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVV 919
            |::  .:.:.|:.||.:.|...    ||:.|.:|:|.:         :.|::||:...|....:.
 Worm   774 FYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTL---------VAILLAVIMSFFYSWKMS 829

  Fly   920 LGIIFYQLRTFYLKTSRDVKRMEAITRSPV---YSHLAA--SLTGLSTIRAFGAQ-RVLEAEFDN 978
            |.::.:....:......|....:|:....:   .|:.||  :|..:.|:||...: ||:.....:
 Worm   830 LQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNMENRVILLVTSH 894

  Fly   979 YQDMHSSAF----------------YMFI-STSRAFGYWL---------DCFCVIYIAIITLSFF 1017
            .|.:.:|.|                |.|| :.|..||.||         |.:.|:....:|.|:
 Worm   895 LQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASY- 958

  Fly  1018 IFPPANGGDVGLAIT------QAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAP 1076
                     .|.|:.      :|:...|:                 :..:..|..|       .|
 Worm   959 ---------AGSAVAYLPDHRKAIHAAGL-----------------IFHLFTYPAI-------MP 990

  Fly  1077 ADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALF 1141
            .|....|...:.|:|....:|..|. ....:.:|..:|..:.....:.:||.:|:|||::|:.|.
 Worm   991 YDSSQGKRNIKNGEIELKNVSFEYA-QRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLE 1054

  Fly  1142 RLSYN-DGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYN--LDPFDEYSDDKLWRSLE 1203
            |..:. ||.|.||:.:..::.||.||..:|::.||||||:.:::.|  .......|..::.::|:
 Worm  1055 RFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALK 1119

  Fly  1204 EVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQ 1268
            .......|:..|.||.:.:.|.|...|.||:|.:.:||||||..::|::||||:.:|..::.::|
 Worm  1120 VANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQ 1184

  Fly  1269 TTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTG 1330
            ..:....:..:.:.:||||.|::::|.:.|:..|:..|.||..||  |....::..:|::.|
 Worm  1185 NALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEEL--LRKRSIYWRLVQKQG 1244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	310/1345 (23%)
		ABC_membrane	107..360	CDD:294371	51/295 (17%)
		ABCC_MRP_domain1	445..645	CDD:213217	74/215 (34%)
		ABC_membrane	815..1014	CDD:294371	51/242 (21%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	67/223 (30%)
pgp-5	NP_001257116.1	PTZ00265	27..1241	CDD:240339	311/1357 (23%)
		ABC_membrane	41..322	CDD:294371	49/280 (18%)
		ABC_MTABC3_MDL1_MDL2	374..611	CDD:213216	79/239 (33%)
		ABC_membrane	688..955	CDD:294371	63/301 (21%)
		ABC_MTABC3_MDL1_MDL2	1005..1243	CDD:213216	71/240 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000