Protein Alignment CG7627 and pgp-10

DIOPT Version :9

• Sequence 1: NP_001245943.1
• Gene: CG7627 / 34148
• FlyBaseID: FBgn0032026
• Length: 1355
• Species: Drosophila melanogaster
• Sequence 2: NP_509205.2
• Gene: pgp-10 / 180981
• WormBaseID: WBGene00004004
• Length: 1382
• Species: Caenorhabditis elegans
• Alignment Length: 1464
• Identity: 314/1464 - (21%)
• Similarity: 572/1464 - (39%)
• Gaps: 398/1464 - (27%)

  Fly    78 LLRALLRVFGWY----FALLGLVLFLLELGLRTLQPIFLLKLIAYYTHGSESIESAYYYAAGVIL 138
            ||::.|..|.|.    |..:.::....:|||:.|...:             .|:..:.::|....
 Worm   105 LLQSALPPFVWLIMGNFVSISILREEGKLGLKNLTSDY-------------PIDDQFAHSATPAF 156

  Fly   139 CSALNVIIMHPYMLGTMHVGLKMRVGMCSMIY-------RKALRLSKSALGDTTAGHVVNLMSND 196
            .|.|.:.|  ...:......:...:.....::       ||.|.:..|.|....:|||..::...
 Worm   157 ISMLGLSI--AMFIAAFCQRIAWEISSIRQVFRIKKAYIRKLLLMDISWLESRQSGHVAAMLQES 219

  Fly   197 VGRLDLATIFVHYLWVG---PLETLFITYLMYREIGIAAVFG---VAFMLLFIPLQ-----AYLG 250
            ...:        |..:.   |:....::||:. .||:.....   ..||.|.|||.     .|..
 Worm   220 ADSI--------YNGISDHLPMVVFILSYLLV-NIGVCLYIQWDVTLFMCLAIPLLIISRILYSK 275

  Fly   251 KRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEIN-----AIRHVSY 310
            ...:.:...|.|: ::...::||..:.|..:..:|           |:|::||     :..|...
 Worm   276 WFANTMEEETKLQ-NKITNLVNETFNCITTVISFA-----------AQKQKINKFEKLSAEHSKL 328

  Fly   311 IRGILLSFIIFLTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRT---------TMTVFFPQ 366
            ....|.|.::|.:...|.|:             |:.|.....|.|.|.         .:.:
 Worm   329 TEERLRSSVVFDSLTQILLT-------------ELIFTGALCYGIWRVADNSPGRLCALAI---- 376

  Fly   367 GISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPI 431
            .:..|..|.:||    .:..:..|...|.:.::.|..           .::.:.|.|       :
 Worm   377 NMLYMCVTSISI----GFHMNGATRAKDNAKEICEVL-----------NEQPKIEVE-------L 419

  Fly   432 ATVNENAK----------------LSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVG 480
            |:::.|..                :.:..:....:...:........|.|::.:|:.|..:.|||
 Worm   420 ASIDNNIDYVPVTRCKYRRQSMKFMGKGALHFRDIHFSYPSRKETEVLRGISFKVEAGEKIAIVG 484

  Fly   481 RTGSGKSSLIQAIL-------GELPAESGEIK------VNGSMSYASQEPWLFSGTVRQNILFGQ 532
            .:|||||:|...:|       |.:..:...||      :.|..|..||||.||.||:..||.:|:
 Worm   485 SSGSGKSTLTALLLRFYDPTKGAILLDGENIKTMCPDDLRGQCSLVSQEPVLFDGTISDNIRYGR 549

  Fly   533 PMD--RRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDD 595
             :|  ::......:|....:....||...:|.|||||..||||||.|:::||||.|:..:.:.|:
 Worm   550 -LDATQQEINDAARKVGAWKFINSLPDGMQTRVGERGHQLSGGQKQRVAIARAVIRKPIVLIFDE 613

  Fly   596 PLSAVDTHVARHLFEQCMRGYL----RERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESL- 655
            ..||:|     ::.|:.:...:    .....|...|:|..::::|:|:::.:|::...|..:.|
 Worm   614 ATSALD-----NIHEEEVNAAIDLASEGLTTITIAHRLSTIKNSDRIIVLHEGKIVEEGVPDELI 673

  Fly   656 -RESGLDFASMLAD--------------------------------PERDEQSEERSRSRSG--- 684
             ..:|: |..|..|                                |..|...:.|:.:||.
 Worm   674 ADANGI-FHKMYNDQRLDQLTQQHQQLHQQQAKPPSLQQQMSFSPPPNMDPDQQRRAWARSSLGG 737

  Fly   685 ---------------------------------SYTHSHS-DQRRNSEQSLLSMADSCMDDLEAE 715
                                             .|:..|| |.:::::    ||.|.  |||..:
 Worm   738 NKKLGKSYSVNSMEKEKLKLPVMSKKKSERLDYKYSKVHSMDVKQHTD----SMHDD--DDLPGK 796

  Fly   716 QANNQERQEAGQIGLRLYSKYFKAGGGFFA-----------FFVMMGFCVLSQGLASLGDYFLSY 769
            :.|....::.      :||  ::.|....|           |::::.|.|.|
 Worm   797 ETNFTVLKDL------IYS--YRTGLPLLAGAIPTTIVRAVFYLLICFQVAS------------- 840

  Fly   770 WVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSF- 833
                                          :.:|.::.|.|.. ..||.|..:.|.|:.|...|
 Worm   841 ------------------------------VLEISIAPDEERA-LQIFIVAAIYTALIIVKTIFE 874

  Fly   834 ----LFFNLAMKASIR-LHNSMFRGITRAAMYFFN--TNPSGRILNRFSKDMGQVDEILPAVMMD 891
                :|..|......: :.|.|||.:.|....:|:  .|..||::::...:...::||:..
 Worm   875 ALGRIFIALYGHGFCKFMRNEMFRKVLRHGAAYFDEERNSPGRLVHKVINESSTLNEIMEQ---- 935

  Fly   892 VIQIFLALAGIVI-VIAVVNPLFLIPTVVLGIIFYQLRTFY----LKTSRDVKRM-EAITRSPVY 950
              ::.:.:.|:|. :.::|..|::...:.| :..:|...::    |:.....||. :.:......
 Worm   936 --KLDMLIPGVVCSLFSIVCALWINWKMAL-LCSFQFPAYFVIRILQIREGTKRQRQMVDEEKKA 997

  Fly   951 SHLAA-SLTGLSTIRAFGAQRVLEAEFDNY---------QDMHSSAFY--MFISTSRAFGYWLDC 1003
            ::||: .|..:|||:|:.    |::.|.|.         |.|...:..  :..:...:|.|
 Worm   998 ANLASVVLANMSTIKAYN----LQSHFYNVFCDALKPVSQCMQKQSLISALVFACQYSFTY---- 1054

  Fly  1004 FCVIYIAIITLSFFIFPPANGGDV-----GLAITQAMGMTGMVQWGMRQSAEL------------ 1051
               |.|| |||.|        |.|     .:::...|.:..:.|:|....::|
 Worm  1055 ---ILIA-ITLHF--------GKVMMLANEISVFDYMRVVLLTQFGANFFSQLIASVSDFTKAQI 1107

  Fly  1052 --ENTMTAV-ERVVEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSL 1113
              ||.|..: |..|:.:::..||.        .||.   :|.:...::|.|| |......||.:|
 Worm  1108 AAENVMRVIREPPVDMDNLSEEGL--------RPKL---EGNLCLKDVSFRY-PSRPIVPVLTNL 1160

  Fly  1114 SFVIKPKEKVGIVGRTGAGKSSLINALFRLSYN--DGSVLIDKRDTSEMGLHDLRSKISIIPQEP 1176
            :..::..|.:.:||.:|:||||:| :||:..||  ||.|:|||.:...:....||..|..:.|||
 Worm  1161 NLKVRGGESIALVGPSGSGKSSVI-SLFQRMYNATDGVVIIDKYNIKSINPAYLRRCIVQVGQEP 1224

  Fly  1177 VLFSGTMRYNLDPF----DEYSDDKLWRSLEEVKLKEV---VADLPSGLQSKITEGGTNFSVGQR 1234
            .|||.|::.|: .|    .|.:.||:   :|..|:.::   :..||.|..:::.|.|...|.||:
 Worm  1225 DLFSFTIKENI-AFGMMESEATIDKV---IEAAKIADIHNFITSLPQGYDTEVGEFGAQLSGGQK 1285

  Fly  1235 QLVCLARAILRENRILVMDEATANVDPQTDGLIQTTI----RNKFKECTVLTIAHRLHTIMDSDK 1295
            |.:.:||||:|:..:|::||||:.:|..::..:|...    |:...:||.:.|||||.||.:.||
 Worm  1286 QRIAIARAIIRKPTVLLLDEATSALDSASEREVQNAFERVKRSTKTQCTCIQIAHRLSTIRNVDK 1350

  Fly  1296 VLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQT 1329
            :.|:..|...|.|:..:|:.|  ..:::.|.:.|
 Worm  1351 IYVIVHGEIAEEGSHEQLINL--KGIYYEMNQMT 1382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	311/1448 (21%)
		ABC_membrane	107..360	CDD:294371	48/284 (17%)
		ABCC_MRP_domain1	445..645	CDD:213217	62/218 (28%)
		ABC_membrane	815..1014	CDD:294371	47/224 (21%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	81/233 (35%)
pgp-10	NP_509205.2	MdlB	73..687	CDD:224055	136/663 (21%)
		ABC_membrane	156..381	CDD:294371	45/264 (17%)
		ABC_MTABC3_MDL1_MDL2	450..687	CDD:213216	68/243 (28%)
		ABC_membrane	823..1099	CDD:294371	63/346 (18%)
		MdlB	825..1382	CDD:224055	156/646 (24%)
		P-loop_NTPase	1141..1381	CDD:304359	83/247 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910