Protein Alignment CG7627 and mrp-2

DIOPT Version :9

• Sequence 1: NP_001245943.1
• Gene: CG7627 / 34148
• FlyBaseID: FBgn0032026
• Length: 1355
• Species: Drosophila melanogaster
• Sequence 2: NP_508121.1
• Gene: mrp-2 / 180408
• WormBaseID: WBGene00003408
• Length: 1525
• Species: Caenorhabditis elegans
• Alignment Length: 1431
• Identity: 476/1431 - (33%)
• Similarity: 748/1431 - (52%)
• Gaps: 214/1431 - (14%)

  Fly     7 ADLPEN--------PREHCNFISAACF-WYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLC 62
            ||:|.:        |....:||:...| |:|...:: |.|::|:.:||:...:..|:|.|.....
 Worm   194 ADVPSDMYKSESSCPEYTASFINRLTFQWFTGLAYL-GNKKSLENEDLWDLNEIDKAENLIPSFM 257

  Fly    63 ASWELELEK-------------TKGKPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLK 114
            .:.:..:::             .|..|:.:..:.:.:. |..|.|....|....|:.|.|..|.:
 Worm   258 QNLKPRIDEYHQNIKKDPSAALPKNHPSFVIPIFKTYK-YTLLAGFFYKLCFDMLQFLAPQLLKQ 321

  Fly   115 LIAYYTHGSESIESAYYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKS 179
            ||.:....::.:.........:...|.|..:.:|.|......:|:.:|..:.|.:|.|||.||..
 Worm   322 LIGFIEDKNQPVWIGCSIVGIMFFSSFLQSMFLHQYYHSMFRLGMHVRSVLTSAVYSKALNLSNE 386

  Fly   180 ALGDTTAGHVVNLMSNDVGRL-DLA-TIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLF 242
            |....|.|.:|||||.|:.:: |:| ||.:  .|..||:.....|.:::.:|:||:.|:..::|.
 Worm   387 ARKGKTIGAIVNLMSVDIQKIQDMAPTIML--FWSAPLQIFLSIYFLWKFLGVAALAGLVVLILA 449

  Fly   243 IPLQAYLG-----KRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEI 302
            :|:...:.     .:|..::|:     |||::||:||::|::|:|:|:||...|:||...|::|:
 Worm   450 LPVNGLIAIQMRKCQTEQMKLK-----DERIKMMSEILNGMKVLKLYSWERSMENMVLKIREREL 509

  Fly   303 NAIRHVSY-IRGILLSFII--FLTRVSIFLSLVGYVLL---GTFLTPEVAFLITAYYNILRTTMT 361
            :.::.:|| :..|:.|:|.  ||..|   :|.|.||.|   ...||||:.|:..:.::|||..:.
 Worm   510 HILKKLSYFMAAIVFSWICAPFLASV---ISFVVYVYLDPENNVLTPEITFVALSLFDILRMPLA 571

  Fly   362 VFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETV-HADGDEERDEAEDK 425
            : ......:..:..||..|::::..::|.               |.|.:: |.:.|
 Worm   572 M-VAMVYGEAVQCSVSNTRLKEFFAAEEM---------------SPQTSISHGETD--------- 611

  Fly   426 LLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLI 490
                             :.|.:...:..|. :..|.:|..::.::|.|.::.|||:.|||||||:
 Worm   612 -----------------SAIEVENGLFSWS-SDEDPTLREISFKIQKGQLVAIVGKVGSGKSSLL 658

  Fly   491 QAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELL 555
            .|:|||:...||.:::||:::|..|:.|:.:.::|.||||.:|.|...|..|||.|||:.|...|
 Worm   659 HALLGEMNKLSGSVQINGNIAYVPQQAWIQNMSLRNNILFNKPYDLENYEDVVKNCALKEDLANL 723

  Fly   556 PFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCM---RGYL 617
            |..|:|.:||:|.:||||||.|:|||||||:...|.||||||||||:||.:|:||..:   .|.|
 Worm   724 PAGDRTEIGEKGINLSGGQKQRVSLARAVYQNPDIILLDDPLSAVDSHVGKHIFENVISSSTGCL 788

  Fly   618 RERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLDFASMLADPERDEQSEERSR-- 680
            ..:..:|.||.|.:|:|.||::::.:|.:|.:|||:.|..:...||..| :....|:|:.|.|
 Worm   789 ASKTRVLVTHGLTYLKHCDQLIVLKEGTISELGTYQELLNNSGAFAEFL-EEFLIEESKTRGRVA 852

  Fly   681 ------------------------SRSGSYTHSHSDQ-----------RRNSEQSLL-------- 702
                                    .|..|:....||:           |.:|.:|:|
 Worm   853 SIGDGSGEVDEILRDLGQVKPGILKRLESHLSQESDKEDTSARAIEYSRDSSRRSVLLHSPRSQH 917

  Fly   703 ----SMADSCMDDLEAEQANNQ----ERQEAGQIGLRLYSKYFKAGG---GFFAFFVMMGFCVLS 756
                ::..:..:|:.| |.|.|    |..|.|::...:|..||:|..   ....||:.:|    |
 Worm   918 EENEALLGAISEDVPA-QENTQLIEKETVETGKVKFEVYIAYFQAISIPITLLFFFLYVG----S 977

  Fly   757 QGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVIT 821
            .||..|.:::|:       .::..|.:.:.|.|:.        ..::|:.....|..::   |:.
 Worm   978 SGLGILSNFYLA-------KLSDHAKSGNRTSSDA--------KMELGIYAVLGMGQSF---VVL 1024

  Fly   822 VLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILP 886
            :.:|::|:.        .::||..||..:...|.|:.|.||:..|.||||||..||:..:|..||
 Worm  1025 IASIILTIG--------VLRASRILHAGLLGNIMRSPMAFFDVTPIGRILNRIGKDIEAIDRTLP 1081

  Fly   887 AVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYS 951
            .|:..:......:...::||....|...|...:|.:|::.:..||:.|||.:||:|:.:|||:||
 Worm  1082 DVIRHMSMTIFNVVATLVVIMWATPWAGIAFAILSVIYFIVLRFYISTSRQLKRLESASRSPIYS 1146

  Fly   952 HLAASLTGLSTIRAFGAQRVLEAEFDNY-------QDMHSSAFYMFISTSRAFGYWLDCFCVIYI 1009
            |...|:.|.|:|||||.       .||:       .|.|..|:|..|..:|    ||.....:..
 Worm  1147 HFQESIQGASSIRAFGV-------VDNFIKQSQQRVDDHLIAYYPSIVANR----WLAVRLEMVG 1200

  Fly  1010 AIITLS-------FFIFPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDI 1067
            .:|.||       |...|..:.|.|||:::.|:.:|..:.|.:|.::|||..:.:|||:.||...
 Worm  1201 NLIVLSAAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVSVERIKEYTVT 1265

  Fly  1068 EPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAG 1132
            ..||   ..:.:...|||||:|:|.....|:||.|.  .:.||..:|..|.|.||||||||||||
 Worm  1266 PTEG---NNSRRLAAKSWPEKGEISIKNFSVRYRPG--LDLVLHGISAHIAPSEKVGIVGRTGAG 1325

  Fly  1133 KSSLINALFRLSYND-GSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDD 1196
            ||||..||||:...| ||:.||..:.:.:.|..|||.::|:||:||||||||:.|||||..|||.
 Worm  1326 KSSLTLALFRIIEADGGSIEIDGINIANLQLEQLRSCLTIVPQDPVLFSGTMKMNLDPFSAYSDS 1390

  Fly  1197 KLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDP 1261
            ::|.:||...||..|..|..||:.||:|||.|.|||||||:|||||:||:.::||:|||.|.||.
 Worm  1391 QVWEALENAHLKPFVKSLQDGLEHKISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDV 1455

  Fly  1262 QTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMV 1326
            :||.|||.|||.:|||||||||||||:|:||||::||:|.||..||.:|..||...|. :|:.|.
 Worm  1456 ETDSLIQKTIREQFKECTVLTIAHRLNTVMDSDRLLVLDKGRVAEFDSPKNLLANPDG-IFYSMA 1519

  Fly  1327 K 1327
            |
 Worm  1520 K 1520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	468/1412 (33%)
		ABC_membrane	107..360	CDD:294371	82/265 (31%)
		ABCC_MRP_domain1	445..645	CDD:213217	89/202 (44%)
		ABC_membrane	815..1014	CDD:294371	64/205 (31%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	129/221 (58%)
mrp-2	NP_508121.1	MRP_assoc_pro	25..1522	CDD:188098	476/1431 (33%)
		ABC_membrane	309..570	CDD:294371	83/270 (31%)
		ABCC_MRP_domain1	614..816	CDD:213217	89/202 (44%)
		ABC_membrane	971..1239	CDD:279056	87/308 (28%)
		ABCC_MRP_domain2	1284..1504	CDD:213211	129/221 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.730