DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and mrp-7

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_507812.3	Gene:	mrp-7 / 180289	WormBaseID:	WBGene00003413	Length:	1525	Species:	Caenorhabditis elegans

Alignment Length:	1409	Identity:	481/1409 - (34%)
Similarity:	735/1409 - (52%)	Gaps:	179/1409 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLKTADLPENPREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWE- 66
            |.|:|..||   ...:|::....|:.......|.:|.|:..|::...:...:|.|.....:.||
Worm   201 SSKSAASPE---LQSSFLNRLTLWWFNSIPWTGARRDLEIDDIFELNERSGTEFLSELWESFWEP 262

  Fly    67 -----------------LELEKTKGK-PNLLRALLRVFGWYFALLGLVLFLLELGLRTLQ---PI 110
                             .|.||.... |:::.:|..:|.|.|.|...:.|:.:    |:|   |.
Worm   263 KRLKYIHDTSIWAKKDPSEQEKDPVVIPSVVSSLFMMFRWEFLLASTLKFVSD----TMQFASPF 323

  Fly   111 FLLKLIAYYTHGSESIESAYYY---AAGVIL--CSALNVIIMHPYMLGTMHVGLKMRVGMCSMIY 170
            .|.:|:.:.     |.::|.::   |..:::  .|.|..:|::.|......:|.|::..:.:.:|
Worm   324 LLHELLNFI-----SAKNAPFWKGMALSILMFSVSELRSLILNGYFYIMFRMGTKIQTSLTAAVY 383

  Fly   171 RKALRLSKSALGDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFG 235
            :|.|.:|.||..|.|.|.:||||:.||.|..:.|..:...|..|.:..|....::..:|.:|:.|
Worm   384 KKTLLISNSARRDRTVGEIVNLMAIDVERFQMITPQIQQFWSCPYQITFALVYLFITLGYSALPG 448

  Fly   236 VAFMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKK 300
            |..|::|:|:...........::......|||.:|:||:::||:|:|:||||:|.|..:...|.|
Worm   449 VVIMVIFVPMNIISSMIVRKWQIEQMKLKDERTKMVNEVLNGIKVVKLYAWEVPMEAYIDEIRTK 513

  Fly   301 EINAIRHVSYIRGILLSFIIFLTRVSIFLSLVGYVLLGTF--------LTPEVAFLITAYYNILR 357
            |:..|:..:.:|.||.||    ...|.|  ||.....|||        |||::||:..|.:|.||
Worm   514 ELALIKKSAMVRNILDSF----NTASPF--LVALFSFGTFVLSNPSHLLTPQIAFVSLALFNQLR 572

  Fly   358 TTMTVFFPQGISQMAETLVSIKRVQKYMQSDETN--VMDMSVDLTEDFQGSNQETVHADGDEERD 420
            :.||: ....|:|..:.:||.||:::::.::|.:  .:|.||
Worm   573 SPMTM-IALLINQAVQAVVSNKRLKEFLVAEELDEKCVDRSV----------------------- 613

  Fly   421 EAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVN--SPDYSLNGVNLRVQPGTMLGIVGRTG 483
                            |.:.|...:.:..|.|.||..  :.:.:|..|:|.....:::.:||:.|
Worm   614 ----------------NIERSHNAVRVENLTASWDPEEAAGEKTLQDVDLTAPRNSLIAVVGKVG 662

  Fly   484 SGKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCAL 548
            ||||||:||:|||:....|.|.|||.::|..|:||:.:.|:|.||.||:|.||:||.:|:..|||
Worm   663 SGKSSLLQALLGEMGKLRGRIGVNGRVAYVPQQPWIQNMTLRDNITFGRPFDRKRYDQVLYACAL 727

  Fly   549 ERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCM 613
            :.|.::||..|:|.:||:|.:||||||||:|||||||:...:|||||||||||.||.||:||:.:
Worm   728 KADIKILPAGDQTEIGEKGINLSGGQKARVSLARAVYQNLDVYLLDDPLSAVDAHVGRHIFEKVI 792

  Fly   614 --RGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESL-RESGLDFASMLADPERDEQS 675
              .|.|||:..||.||.|.:.:.||:|::|.:|::...||:|.| :..||.|..|.......:.|
Worm   793 GPNGLLREKTRILVTHGLTYTKMADEILVMLEGKIEESGTFEHLIKRRGLFFDFMEEYKSGSDNS 857

  Fly   676 EERSRSRSGSY--THSHSDQRRNSEQSLLSMAD---------------SCMDDLE---------- 713
            .|...|:...:  .........|.|..:|::.:               |.|...|
Worm   858 SEAGGSQDDDFEAIGGEIQDYMNPEDVVLTVTNDLDETIRTPELTTQISTMSSPEKPPTGTSPAA 922

  Fly   714 -AEQANNQERQEA---GQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKK 774
             .|..|...::|.   |::.:..|..|.|| .|:......:||.::...|..|..::||.|
Worm   923 ATESQNKLIKKEGIAQGKVEIATYQLYVKA-AGYLLSIAFIGFFIVYMTLQILRSFWLSAW---- 982

  Fly   775 GNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLA 839
                  :|..|.. |....|....|  .:|:.......:|..|.|..:..:.|           .
Worm   983 ------SDEYDPD-SPSAHPMAKGW--RLGVYGALGFSETACFFVALLALVFV-----------G 1027

  Fly   840 MKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVI 904
            .:||..||..:...:.|:.|.|::|.|.||||||.:||:..:|.:||.....::...|.:|..:|
Worm  1028 QRASKNLHGPLIHNLMRSPMSFYDTTPLGRILNRCAKDIETIDMMLPMNFRYLVMCVLQVAFTLI 1092

  Fly   905 VIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQ 969
            ||.:..|||.:..:.|.:|:.....:|:.|||.:||:|::.|||:|||...::.|.::|||||..
Worm  1093 VIIISTPLFAVVILPLALIYLIFLRYYVPTSRQLKRLESVHRSPIYSHFGETIQGAASIRAFGKV 1157

  Fly   970 RVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCF--CVIY----IAIITLSF-FIFPPANGGDV 1027
            .....:.....|......|..:.::|.....|:..  |:|:    .|:::..| :|..|   |.:
Worm  1158 DEFRQDSGRILDTFIRCRYSSLVSNRWLAVRLEFVGNCIIFFAALFAVLSKEFGWITSP---GVI 1219

  Fly  1028 GLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAP---ADKKPPKSWPEQG 1089
            |::::.|:.:|.::.:.:||.:|:|..:.:||||.||.: .|.   |||   ..::|...||.:|
Worm  1220 GVSVSYALNITEVLNFAVRQVSEIEANIVSVERVNEYTN-TPN---EAPWRIEGREPAPGWPSRG 1280

  Fly  1090 KIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVLID 1153
            .:.||..|.||...  .:.||..:|..:...||:||||||||||||...|||| :....|.::||
Worm  1281 VVKFDGYSTRYREG--LDLVLHDISADVAAGEKIGIVGRTGAGKSSFALALFRMIEAAGGRIVID 1343

  Fly  1154 KRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGL 1218
            ..:.|::|||||||.|:||||:|||||||:|:|||||..||||::||:||...||...|.||.||
Worm  1344 DVEVSQIGLHDLRSNITIIPQDPVLFSGTLRFNLDPFFTYSDDQIWRALELAHLKHFAAGLPDGL 1408

  Fly  1219 QSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTI 1283
            ..||:|.|.|.||||||||.||||:||..|:||:|||||.||..||.|||.|||.:||||||.||
Worm  1409 LYKISEAGENLSVGQRQLVALARALLRHTRVLVLDEATAAVDVATDALIQETIREEFKECTVFTI 1473

  Fly  1284 AHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLAD-SKVFHGMV 1326
            ||||:||||.|:::|:|.|..:||.||..|  :|| :..|..||
Worm  1474 AHRLNTIMDYDRIMVLDKGSILEFDTPDAL--MADKNSAFAKMV 1515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	471/1386 (34%)
		ABC_membrane	107..360	CDD:294371	81/268 (30%)
		ABCC_MRP_domain1	445..645	CDD:213217	98/203 (48%)
		ABC_membrane	815..1014	CDD:294371	59/204 (29%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	130/221 (59%)
mrp-7	NP_507812.3	MRP_assoc_pro	14..1518	CDD:188098	481/1409 (34%)
		ABC_membrane	310..575	CDD:294371	83/279 (30%)
		ABCC_MRP_domain1	622..826	CDD:213217	98/203 (48%)
		ABC_membrane	976..1227	CDD:279056	74/277 (27%)
		ABCC_MRP_domain2	1280..1500	CDD:213211	130/221 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.730