DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7627 and haf-3

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_506927.2	Gene:	haf-3 / 180056	WormBaseID:	WBGene00001813	Length:	666	Species:	Caenorhabditis elegans

Alignment Length:	625	Identity:	153/625 - (24%)
Similarity:	283/625 - (45%)	Gaps:	85/625 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   742 GFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPR-----LSTWLR 801
            |.:.:.:|:|...|  |::|      |.::.....:....|..|.|:.::::|.     |:.:.:
Worm    81 GPYKWRIMLGISFL--GISS------SIFLFTPRVLGKLIDEWDETKQDKMDPNDKALLLARFFK 137

  Fly   802 DIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNP 866
            :..:::..          :.:|..:...||.:............|..|:|..:.|..|.||:.|.
Worm   138 ENPIALAG----------VFMLGAIAIAARIYCMHTAGQLVINDLRKSVFNSVLRQDMAFFDKNK 192

  Fly   867 SGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAG-----IVIVIAVVNPLFLIPTVVLG--IIF 924
            .|.|::|.|.|...|...:...:.|..:..:...|     :...:|:...:|::..|::|  .:|
Worm   193 VGEIVSRLSTDALIVGYSVSMNLSDGARALITCFGSGGLMVYTSLAMCKVIFVVVPVIVGTFAVF 257

  Fly   925 YQLRTFYLKTSRDVKRMEAITRSPVYSHLAAS-LTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFY 988
            .:|:..|     .:...||:..:   :.:|.. |:.:.|:|...|:|   .|...|.|..:..:.
Worm   258 GKLQRKY-----TLMMQEAVAGA---NQVATERLSSVRTVRMLVAER---KELAAYSDKINEIWQ 311

  Fly   989 MFISTSRAFGYWLDCFCVIYIAIITLSFFIFPPANGGDVGL------------AITQAMGMTGMV 1041
            :......|.|:....|  .:...:.||..:|..:|....||            |:..|..::.|.
Worm   312 ISKKEGLAKGFMFGSF--QFTGYLALSSILFYGSNLISQGLLTYGELSSFCLYAVLSAGSLSAMS 374

  Fly  1042 QWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTP-DPK 1105
            .:.:    ||...:.|..|:.|.::.||...||........|.     .|.|:.::..|.. ||.
Worm   375 GFYL----ELMKGLGASSRLFELKNREPRIPLEGGVQIGNVKD-----TIRFEHVAFGYADRDPL 430

  Fly  1106 SENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYN--DGSVLIDKRDTSEMGLHDLRSK 1168
            ..|:    ||.:...:...:||.:|:|||::.:.|.|| |:  .|.:|:|..|..::.....|..
Worm   431 FHNI----SFDVPAGKITAVVGSSGSGKSTIASLLLRL-YDPTSGRILVDGTDLKDIDPSYWRRH 490

  Fly  1169 ISIIPQEPVLFSGTMRYN-----LDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTN 1228
            |..:.|||||||.|::.|     |:| :..:|.::..:.::....|.::..|....:|:.|.|:.
Worm   491 IGTVGQEPVLFSTTIKENIIYGSLEP-ENVTDAEIVSAADQSNADEFISRFPIKYDTKVGEHGST 554

  Fly  1229 FSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKF---KECTVLTIAHRLHTI 1290
            .|.||:|.:.:|||::.:..||:|||||:.:|..::.|::..: ||.   .:.||:.|||||.||
Worm   555 LSGGQKQRIAIARALVNKPNILIMDEATSALDASSEYLVRIAL-NKLLANSKQTVMIIAHRLSTI 618

  Fly  1291 MDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMV-KQT 1329
            ..:|:::|:|.|...|.|:..||:.:.|. :|..:| |||
Worm   619 KHADQIVVVDRGSVAESGSYDELIAIPDG-IFRKLVEKQT 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	147/608 (24%)
		ABC_membrane	107..360	CDD:294371
		ABCC_MRP_domain1	445..645	CDD:213217
		ABC_membrane	815..1014	CDD:294371	40/206 (19%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	74/231 (32%)
haf-3	NP_506927.2	MdlB	70..657	CDD:224055	151/623 (24%)
		ABC_membrane	96..366	CDD:279056	54/298 (18%)
		P-loop_NTPase	415..656	CDD:304359	79/248 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000