DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and Abcc1

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_032602.1	Gene:	Abcc1 / 17250	MGIID:	102676	Length:	1528	Species:	Mus musculus

Alignment Length:	1428	Identity:	476/1428 - (33%)
Similarity:	749/1428 - (52%)	Gaps:	220/1428 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKT----- 72
            |....:|:|...||:.....:.|.::.|::.||:...||..||.:...|..:|:.|.:|:
Mouse   209 PESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPV 273

  Fly    73 -------------KG----------------------KPNLLRALLRVFGWYF-------ALLGL 95
                         ||                      :|:|.:.|.:.||.||       ||..|
Mouse   274 RIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKTFGPYFLMSFLYKALHDL 338

  Fly    96 VLFLLELGLRTLQPIFLLKLIAYYTHGSESIE-SAYYYAAGVILCSALNVIIMHPYMLGTMHV-- 157
            ::|   .|.:      :|:||..:.:..|:.: ..|:|.|.:.:.:.|..:.:|.|    .|:
Mouse   339 MMF---AGPK------ILELIINFVNDREAPDWQGYFYTALLFVSACLQTLALHQY----FHICF 390

  Fly   158 --GLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVGR-LDLATIFVHYLWVGPLETLF 219
              |::::..:...:|||||.::.:|...:|.|.:|||||.|..| :|||| :::.:|..||:.:.
Mouse   391 VSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLAT-YINMIWSAPLQVIL 454

  Fly   220 ITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMY 284
            ..|.::..:|.:.:.|||.|:|.:||.|.:..:|...::......|.|:::||||::||:|:|:|
Mouse   455 ALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLY 519

  Fly   285 AWELPFEHMVAFARKKEINAIRHVSYIRG------ILLSFIIFLTRVSIFLSLVGYVLLGTFLTP 343
            ||||.|:..|...|::|:..::..:|:..      :...|::.|:..::|::    |.....|..
Mouse   520 AWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVT----VDERNILDA 580

  Fly   344 EVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQ 408
            :.||:..|.:||||..:.: .|..||.:.:..||:||::.::..:|
Mouse   581 KKAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEE------------------- 625

  Fly   409 ETVHADGDEERDEAEDKLLGPPIATVNENAKLSEA-GISISGLMAKWDVNSPDYSLNGVNLRVQP 472
              :..|..|.|                 :.|..|. .|::......|....|. :|||:...:..
Mouse   626 --LEPDSIERR-----------------SIKSGEGNSITVKNATFTWARGEPP-TLNGITFSIPE 670

  Fly   473 GTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRR 537
            |.::.:||:.|.|||||:.|:|.|:....|.:.:.||::|..|:.|:.:.::|:|||||.|:...
Mouse   671 GALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQEN 735

  Fly   538 RYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDT 602
            .|..|::.|||..|.|:||..|:|.:||:|.:||||||.|:|||||||..:.|||.||||||||.
Mouse   736 YYKAVMEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDA 800

  Fly   603 HVARHLFEQCM--RGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLDFASM 665
            ||.:|:||:.:  .|.|:.:..||.||.:.:|...|.|::|..|::|.:|:|:.|.:....||..
Mouse   801 HVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEF 865

  Fly   666 L---ADPERDEQSEERSRSRSG------------------------SYTHSHSDQRRNSEQSLLS 703
            |   |:.|:|..||:.|.|.||                        |.:.|||........|:..
Mouse   866 LRTYANAEQDLASEDDSVSGSGKESKPVENGMLVTDTVGKHLQRHLSNSSSHSGDTSQQHSSIAE 930

  Fly   704 MADSCMDD-----LEAEQANNQERQEAGQIGLRLYSKYFKAGGGFFAFF-VMMGFCVLSQGLASL 762
            :..:...:     :||::|      :.||:.|.:|..|.||.|.|..|. :.:..|.....|||
Mouse   931 LQKAGAKEETWKLMEADKA------QTGQVQLSVYWNYMKAIGLFITFLSIFLFLCNHVSALAS- 988

  Fly   763 GDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILV 827
                 :||                         ||.|..|..:....:....:..:|...|.||.
Mouse   989 -----NYW-------------------------LSLWTDDPPVVNGTQANRNFRLSVYGALGILQ 1023

  Fly   828 TVARSFLFFNLAMKASI-------RLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEIL 885
            ..|    .|..:|..||       |||..:...:.|:.|.||...|||.::|||||::..||.::
Mouse  1024 GAA----IFGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMI 1084

  Fly   886 PAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVY 950
            |.|:...:....::.|.||:|.:..|:..:....||::::.::.||:.:||.:||:|:::|||||
Mouse  1085 PQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVY 1149

  Fly   951 SHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCF--CVIYIAIIT 1013
            ||...:|.|:|.||||..|.....:.|...|.:..|:|..|..:|.....|:|.  |::..|.:
Mouse  1150 SHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAAL- 1213

  Fly  1014 LSFFIFP--PANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAP 1076
              |.:..  ..:.|.|||:::.::.:|..:.|.:|.|:|:|..:.||||:.||.:.|.    |||
Mouse  1214 --FAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEK----EAP 1272

  Fly  1077 ---ADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLIN 1138
               .:..||.:||..|::.|.:..|||..|  .:.|||.::..|:..||||||||||||||||..
Mouse  1273 WQIQETAPPSTWPHSGRVEFRDYCLRYRED--LDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTL 1335

  Fly  1139 ALFRLSYN-DGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSL 1202
            .|||::.: :|.::||..:.:::|||:||.||:||||:||||||::|.|||||.:|||:::|.:|
Mouse  1336 GLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMAL 1400

  Fly  1203 EEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLI 1267
            |...||..|:.||..|..:..|||.|.|||||||||||||:||:.:|||:|||||.||.:||.||
Mouse  1401 ELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLI 1465

  Fly  1268 QTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTG 1330
            |:|||.:|::||||||||||:||||..:|:|:|.|...|.|.|.||  |....:|:.|.|..|
Mouse  1466 QSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSEL--LQQRGIFYSMAKDAG 1526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	471/1411 (33%)
		ABC_membrane	107..360	CDD:294371	77/264 (29%)
		ABCC_MRP_domain1	445..645	CDD:213217	85/201 (42%)
		ABC_membrane	815..1014	CDD:294371	67/207 (32%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	125/221 (57%)
Abcc1	NP_032602.1	MRP_assoc_pro	7..1527	CDD:188098	476/1428 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..895		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..929		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841647
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.660