DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7627 and Abcc2

DIOPT Version :9

Sequence 1:NP_001245943.1 Gene:CG7627 / 34148 FlyBaseID:FBgn0032026 Length:1355 Species:Drosophila melanogaster
Sequence 2:NP_038834.2 Gene:Abcc2 / 12780 MGIID:1352447 Length:1543 Species:Mus musculus


Alignment Length:1454 Identity:498/1454 - (34%)
Similarity:769/1454 - (52%) Gaps:232/1454 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KTADLPENPREHCNFISAACF-WYTMPTFIKGRK------------------------RTLDTKD 44
            :::|....|....:|:|:..| ||. .|.:||.|                        :|:.|||
Mouse   185 ESSDSTHAPSATASFLSSVTFSWYD-STVLKGYKHPLTIEDVWDIEENLKAKSLTSKFKTIMTKD 248

  Fly    45 LYRA-------LK------EHKSETLGNKLCASWE-LELEKTKGKPN------------LLRALL 83
            |.:|       ||      |..|..|..|...|.: |.||.:|.|..            |::||.
Mouse   249 LQKARQALQRRLKKSQQSPEGTSHGLTKKQSQSQDVLVLEDSKKKKKKSEATKDFPKSWLVKALF 313

  Fly    84 RVFGWYFALLGLVLFLLELG---LRTLQPIFLLKLIAYYTHGSESIESAYYYAAGVILCSALNVI 145
            :.|  |..:  |..|:|:|.   |..|.|..|..||.:...........|.||..:...:.:...
Mouse   314 KTF--YVVI--LKSFILKLAHDILLFLNPQLLKFLIGFVKDPDSYPWVGYIYAILMFSVTLIQSF 374

  Fly   146 IMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVGRLDLATIFVHYL 210
            .:..|......:|:.:|..:.:.:|:|||.||..|....|.|..|||||.|..:|...|.::|.|
Mouse   375 FLQCYFQFCFVLGMTVRTTIIASVYKKALTLSNLARRQYTIGETVNLMSVDSQKLMDVTNYIHLL 439

  Fly   211 WVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEII 275
            |...|:.....:.::||:|.:.:.||..|:|.:|:...|..:...::::.....|:|:::||||:
Mouse   440 WSSVLQIALSIFFLWRELGPSILAGVGLMVLLVPVNGVLATKIRKIQVQNMKNKDKRLKIMNEIL 504

  Fly   276 SGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFL--TRVSIFLSLVGYVLLG 338
            |||:::|.:|||..|:..|...||||:..:...|.::.||: ||:.|  |.||:....| |||:.
Mouse   505 SGIKILKYFAWEPSFKEQVNSIRKKELRNLLRFSQLQTILI-FILHLTPTLVSVITFSV-YVLVD 567

  Fly   339 T--FLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTE 401
            :  .|..|.||.....:||||..:.: .|..||.:.:..||:.|:::|:.||:   :|:|     
Mouse   568 SQNVLNAEKAFTSITLFNILRFPLAM-LPMVISSVIQASVSVDRLEQYLGSDD---LDLS----- 623

  Fly   402 DFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGV 466
                :.:...|.|                     :..:.|||..:       || ...:.::..|
Mouse   624 ----AIRHVCHFD---------------------KAVQFSEASFT-------WD-RDLEATIQDV 655

  Fly   467 NLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFG 531
            ||.::||.::.:||..||||||||.|:|||:....|.|.:.||::|..|:.|:.:||::.|||||
Mouse   656 NLDIKPGQLVAVVGTVGSGKSSLISAMLGEMENVHGHITIKGSIAYVPQQAWIQNGTIKDNILFG 720

  Fly   532 QPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDP 596
            ...|.::|.:|::.|||..|.|:||..|...:||:|.:||||||.|:|||||.|::..||:||||
Mouse   721 SEYDEKKYQRVIEACALLPDLEMLPGGDMAEIGEKGINLSGGQKHRVSLARATYQDADIYILDDP 785

  Fly   597 LSAVDTHVARHLFEQCM--RGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRES- 658
            ||||||||.:|:|.:.:  .|.|..:..||.||.:.||...|:||::.||.:...|:|..|.:. 
Mouse   786 LSAVDTHVGKHIFNKVVGPNGLLSGKTRILVTHGIHFLPQVDEIVVLGKGTILEKGSYSDLMDKK 850

  Fly   659 ---------------------------------GL---------DFASMLADPERDEQSEERSRS 681
                                             ||         |.||:..   |.|.|..|:.|
Mouse   851 GVFAKNWKTFMKHSGPEGEATVDNDSEEEDGDCGLIPTVEEIPDDAASLTM---RRENSLRRTLS 912

  Fly   682 RSGSYTHSHSDQRRNS--EQSLLSMADSCMDDLE----AEQANNQERQEAGQIGLRLYSKYFKAG 740
            ||     |.|..||..  :.||...:.:.::..|    .::...:|..|.|::...:|.||.:|.
Mouse   913 RS-----SRSGSRRGKSLKSSLKIKSVNALNKKEEVVKGQKLIKKEFVETGKVKFSIYLKYLQAV 972

  Fly   741 GGFFAFFVMMGFCVLSQGLASLG-DYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIG 804
            |.:...|::: |.||:. :|.:| :.:||.|.:.    :.:.:..|.:.|:          ||:.
Mouse   973 GWWSLLFIVI-FYVLNY-VAFIGTNLWLSAWTSD----SEKQNGTDNSPSQ----------RDMR 1021

  Fly   805 LSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGR 869
            :.|         |..:.:...:..::.|.........||..||..:...|.||.|.||:|.|:||
Mouse  1022 IGV---------FGALGIAQGIFLLSSSLWSIYACRNASKTLHRQLLTNILRAPMSFFDTTPTGR 1077

  Fly   870 ILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKT 934
            |:|||:.|:..||:.||..:...:..|..:...:::|.:..|:|:|..:.|.|::..::.||:.|
Mouse  1078 IVNRFAGDISTVDDTLPQTLRSWLLCFFGIVSTLVMICMATPIFIIIIIPLSILYVSVQVFYVAT 1142

  Fly   935 SRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGY 999
            ||.::|::::|:||:|||.:.:::||..||||..|:...|..:...|.:....:.:|:::|    
Mouse  1143 SRQLRRLDSVTKSPIYSHFSETVSGLPVIRAFEHQQRFLANSEKQIDTNQKCVFSWITSNR---- 1203

  Fly  1000 WLD----------CFC-----VIYIAIITLSFFIFPPANGGDVGLAITQAMGMTGMVQWGMRQSA 1049
            ||.          .||     |||...:|          |..||..::.|:.:|..:.|.:|.::
Mouse  1204 WLAIRLELVGNLIVFCSALLLVIYKNSLT----------GDTVGFVLSNALNITQTLNWLVRMTS 1258

  Fly  1050 ELENTMTAVERVVEYEDIEPEGALEAP--ADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKS 1112
            |:|..:.||||:.||.:::.    |||  .|||||..||::|:|.|:...:||.|:  .:.|||.
Mouse  1259 EVETNIVAVERINEYINVDN----EAPWVTDKKPPADWPKKGEIQFNNYQVRYRPE--LDLVLKG 1317

  Fly  1113 LSFVIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEP 1176
            ::..||..||||:|||||||||||.|.||| |....|.::||..|.:.:||||||.:::||||:|
Mouse  1318 ITCNIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDIASIGLHDLRGRLTIIPQDP 1382

  Fly  1177 VLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLAR 1241
            :||||.:|.|||||::|||:::||:||...||..||.|..||..::||||.|.|:|||||:||.|
Mouse  1383 ILFSGNLRMNLDPFNKYSDEEIWRALELAHLKSFVAGLQLGLLHEVTEGGDNLSIGQRQLLCLGR 1447

  Fly  1242 AILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVE 1306
            |:||:::|||:|||||.||.:||.||||||||:|.:|||:||||||||||||||::|:|:|:.||
Mouse  1448 AVLRKSKILVLDEATAAVDLETDSLIQTTIRNEFSQCTVITIAHRLHTIMDSDKIMVLDSGKIVE 1512

  Fly  1307 FGTPYELLTLADSKVFHGMVKQTG 1330
            :|:|.||  |::...|:.|.|:.|
Mouse  1513 YGSPEEL--LSNMGPFYLMAKEAG 1534

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7627NP_001245943.1 CFTR_protein 12..1315 CDD:273530 492/1430 (34%)
ABC_membrane 107..360 CDD:294371 81/256 (32%)
ABCC_MRP_domain1 445..645 CDD:213217 90/201 (45%)
ABC_membrane 815..1014 CDD:294371 62/213 (29%)
ABCC_MRP_domain2 1089..1310 CDD:213211 131/221 (59%)
Abcc2NP_038834.2 MRP_assoc_pro 10..1535 CDD:188098 498/1454 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 260..285 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 903..927 10/28 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.830

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