DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and ABCC2

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_000383.2	Gene:	ABCC2 / 1244	HGNCID:	53	Length:	1545	Species:	Homo sapiens

Alignment Length:	1434	Identity:	483/1434 - (33%)
Similarity:	754/1434 - (52%)	Gaps:	205/1434 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NPREHCNFISAACF-WYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTK-- 73
            ||....:|:|:..: ||. ...:||.||.|..:|::...:|.|::||.:|.....:.||:|.:
Human   193 NPSSIASFLSSITYSWYD-SIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRA 256

  Fly    74 -------------------------------------------------GKPNLLRALLRVFGWY 89
                                                             .|..|::||.:.|  |
Human   257 LQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTF--Y 319

  Fly    90 FALLGLVLFLLELGLRTLQPIF------LLKLIAYYTHGSESIESAYYYAAGVILCSAL-NVIIM 147
            ..|  |..|||:|    :..||      ||||:..:....::.....|..|.::..:|| ....:
Human   320 MVL--LKSFLLKL----VNDIFTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFCL 378

  Fly   148 HPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVGRLDLATIFVHYLWV 212
            ..|......:|:|:|..:.:.:|:|||.||..|..:.|.|..|||||.|..:|...|.|:|.||.
Human   379 QCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWS 443

  Fly   213 GPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISG 277
            ..|:.:...:.::||:|.:.:.||..|:|.||:.|.|..::..::::.....|:|:::||||:||
Human   444 SVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSG 508

  Fly   278 IQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFLTRVSI-FLSLVGYVLL--GT 339
            |:::|.:|||..|...|...||||:..:...|.::.::: |:..||.|.: .::...|||:  ..
Human   509 IKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVI-FVFQLTPVLVSVVTFSVYVLVDSNN 572

  Fly   340 FLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQ 404
            .|..:.||.....:||||..::: .|..||.|.:..||.:|::||:..|:.:...:..|...|
Human   573 ILDAQKAFTSITLFNILRFPLSM-LPMMISSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFD-- 634

  Fly   405 GSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLR 469
                                           :..:.|||..:       |:.:| :.::..|||.
Human   635 -------------------------------KAMQFSEASFT-------WEHDS-EATVRDVNLD 660

  Fly   470 VQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPM 534
            :..|.::.::|..||||||||.|:|||:....|.|.:.|:.:|..|:.|:.:||::.|||||...
Human   661 IMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEF 725

  Fly   535 DRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSA 599
            :.:||.:|::.|||..|.|:||..|...:||:|.:||||||.|||||||.|:...||||||||||
Human   726 NEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSA 790

  Fly   600 VDTHVARHLFEQCM--RGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLDF 662
            ||.||.:|:|.:.:  .|.|:.:..:|.||.:.||...|:||::..|.:...|:|.:|.....:|
Human   791 VDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855

  Fly   663 ASML------ADPE----------------------------------RDEQSEERSRSRSGSYT 687
            |..|      ..||                                  |.|.|..|:.|||....
Human   856 AKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSN 920

  Fly   688 HSHSDQRRNSEQSLLSMADSCMDD---LEAEQANNQERQEAGQIGLRLYSKYFKAGGGFFAFFVM 749
            ..|....|||.::  ...:|..:|   ::.::...:|..|.|::...:|.:|.:|.|.|..||::
Human   921 GRHLKSLRNSLKT--RNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFII 983

  Fly   750 MGFCVLSQGLASLG-DYFLSYWVTKK---GNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAE 810
            :.|.:.|  :|.:| :.:||.|.:..   .:..|.|...|.        |:..: ..:||:..
Human   984 LAFVMNS--VAFIGSNLWLSAWTSDSKIFNSTDYPASQRDM--------RVGVY-GALGLAQG-- 1035

  Fly   811 MLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFS 875
                          |.|.:|..:..|.....::| ||..:...|.||.|.||:|.|:|||:|||:
Human  1036 --------------IFVFIAHFWSAFGFVHASNI-LHKQLLNNILRAPMRFFDTTPTGRIVNRFA 1085

  Fly   876 KDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKR 940
            .|:..||:.||..:...|..||.:...:::|.:..|:|.|..:.||||:..::.||:.|||.::|
Human  1086 GDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRR 1150

  Fly   941 MEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCFC 1005
            ::::||||:|||.:.:::||..||||..|:......:...|.:....:.:|:::|.....|:...
Human  1151 LDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVG 1215

  Fly  1006 VIYIAIITLSFFIFPPANGGD-VGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEP 1069
            .:.:....|...|:.....|| ||..::.|:.:|..:.|.:|.::|:|..:.||||:.||..:|.
Human  1216 NLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVEN 1280

  Fly  1070 EGALEAP--ADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAG 1132
                |||  .||:||..||.:|||.|:...:||.|:  .:.||:.::..|...||:|:|||||||
Human  1281 ----EAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPE--LDLVLRGITCDIGSMEKIGVVGRTGAG 1339

  Fly  1133 KSSLINALFR-LSYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDD 1196
            ||||.|.||| |....|.::||..|.:.:||||||.|::||||:|:||||::|.|||||:.|||:
Human  1340 KSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDE 1404

  Fly  1197 KLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDP 1261
            ::|::||...||..||.|..||..::||.|.|.|:|||||:||.||:||:::|||:|||||.||.
Human  1405 EIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDL 1469

  Fly  1262 QTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMV 1326
            :||.||||||:|:|..|||:|||||||||||||||:|:|.|:.:|.|:|.|||.:...  |:.|.
Human  1470 ETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGP--FYFMA 1532

  Fly  1327 KQTG 1330
            |:.|
Human  1533 KEAG 1536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	478/1417 (34%)
		ABC_membrane	107..360	CDD:294371	81/262 (31%)
		ABCC_MRP_domain1	445..645	CDD:213217	86/201 (43%)
		ABC_membrane	815..1014	CDD:294371	61/198 (31%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	127/221 (57%)
ABCC2	NP_000383.2	SunT	8..1537	CDD:331423	483/1434 (34%)
ABCC2	NP_000383.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..284		0/30 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151611
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.760