DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7627 and ABCC4

DIOPT Version :9

Sequence 1:NP_001245943.1 Gene:CG7627 / 34148 FlyBaseID:FBgn0032026 Length:1355 Species:Drosophila melanogaster
Sequence 2:NP_005836.2 Gene:ABCC4 / 10257 HGNCID:55 Length:1325 Species:Homo sapiens


Alignment Length:1368 Identity:597/1368 - (43%)
Similarity:862/1368 - (63%) Gaps:106/1368 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 DLPENPREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELEL--- 69
            ::..||.:..|..|...||:..|.|..|.||.|:..|:|..|.|.:|:.||.:|...|:.|:   
Human     7 EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRA 71

  Fly    70 EKTKGKPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYTH----GSESIESAY 130
            |....||:|.||:::.:...:.:|| :..|:|...:.:|||||.|:|.|:.:    .|.::.:||
Human    72 ENDAQKPSLTRAIIKCYWKSYLVLG-IFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAY 135

  Fly   131 YYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSN 195
            .||..:..|:.:..|:.|.|.......|:::||.||.||||||||||..|:|.||.|.:|||:||
Human   136 AYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSN 200

  Fly   196 DVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRT 260
            ||.:.|..|:|:|:||.|||:.:.:|.|::.||||:.:.|:|.:::.:|||:..||..|.||.:|
Human   201 DVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKT 265

  Fly   261 ALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFLTRV 325
            |..||.|:|.|||:|:||::|||||||..|.:::...|||||:.|...|.:||:.|:.....:::
Human   266 ATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKI 330

  Fly   326 SIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDET 390
            .:|::...|||||:.:|....|:....|..:|.|:|:|||..|.:::|.:|||:|:|.::..||.
Human   331 IVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEI 395

  Fly   391 NVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAG---ISISGLMA 452
            :                                           ..|.:|...|   :.:....|
Human   396 S-------------------------------------------QRNRQLPSDGKKMVHVQDFTA 417

  Fly   453 KWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQEP 517
            .||..|...:|.|::..|:||.:|.:||..|:|||||:.|:||||....|.:.|:|.::|.||:|
Human   418 FWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQP 482

  Fly   518 WLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLAR 582
            |:||||:|.|||||:..::.||.||:|.|||::|.:||...|.|::|:||.:||||||||::|||
Human   483 WVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLAR 547

  Fly   583 AVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHADQIVIMDKGRVS 647
            |||::..||||||||||||..|:|||||.|:...|.|:|.||.|||||:|:.|.||:|:..|::.
Human   548 AVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMV 612

  Fly   648 AVGTYESLRESGLDFASMLADPERDEQSEE---------RSRSRSGSYTHSHSDQRRNSEQSLLS 703
            ..|||....:||:||.|:|  .:.:|:||:         |:|:.|.|...|....|.       |
Human   613 QKGTYTEFLKSGIDFGSLL--KKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRP-------S 668

  Fly   704 MADSCMDDLEAEQAN---NQERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDY 765
            :.|..::..:.|...   ::|.:..|::|.:.|..||:||..:..|..::.....:|....|.|:
Human   669 LKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDW 733

  Fly   766 FLSYWVTKKG--NVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTY--IFTVITVLTIL 826
            :||||..|:.  ||......|.|   |:|:                  |:.|  |::.:||.|:|
Human   734 WLSYWANKQSMLNVTVNGGGNVT---EKLD------------------LNWYLGIYSGLTVATVL 777

  Fly   827 VTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMD 891
            ..:|||.|.|.:.:.:|..|||.||..|.:|.:.||:.||.||||||||||:|.:|::||...:|
Human   778 FGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLD 842

  Fly   892 VIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAAS 956
            .||..|.:.|:|.|...|.|...||.|.|||||..||.::|:|||||||:|:.|||||:|||::|
Human   843 FIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSS 907

  Fly   957 LTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCFCVIYIAIITL-SFFIFP 1020
            |.||.||||:.|:...:..||.:||:||.|:::|::|||.|...||..|.:::.|:.. |..:..
Human   908 LQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAK 972

  Fly  1021 PANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSW 1085
            ..:.|.||||::.|:.:.||.||.:|||||:||.|.:||||:||.|:|.|...|  ..|:||.:|
Human   973 TLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWE--YQKRPPPAW 1035

  Fly  1086 PEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSV 1150
            |.:|.|:||.::..|:|.  ...|||.|:.:||.:|||||||||||||||||:||||||..:|.:
Human  1036 PHEGVIIFDNVNFMYSPG--GPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKI 1098

  Fly  1151 LIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLP 1215
            .|||..|:|:||||||.|:||||||||||:||||.|||||:|::|::||.:|:||:|||.:.|||
Human  1099 WIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLP 1163

  Fly  1216 SGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTV 1280
            ..:.:::.|.|:||||||||||||||||||:|:||::|||||||||:||.|||..||.||..|||
Human  1164 GKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTV 1228

  Fly  1281 LTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTGHATYESLLKIAQKAF 1345
            |||||||:||:||||::|:|:||..|:..||.||...:| :|:.||:|.|.|...:|.:.|::.:
Human  1229 LTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKES-LFYKMVQQLGKAEAAALTETAKQVY 1292

  Fly  1346 ENR 1348
            ..|
Human  1293 FKR 1295

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7627NP_001245943.1 CFTR_protein 12..1315 CDD:273530 586/1329 (44%)
ABC_membrane 107..360 CDD:294371 109/256 (43%)
ABCC_MRP_domain1 445..645 CDD:213217 105/199 (53%)
ABC_membrane 815..1014 CDD:294371 98/200 (49%)
ABCC_MRP_domain2 1089..1310 CDD:213211 142/220 (65%)
ABCC4NP_005836.2 CFTR_protein 11..1269 CDD:273530 588/1336 (44%)
ABC_membrane 96..365 CDD:294371 112/269 (42%)
ABCC_MRP_domain1 410..610 CDD:213217 105/199 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 657..688 6/37 (16%)
ABC_membrane 718..991 CDD:279056 120/293 (41%)
ABCC_MRP_domain2 1039..1258 CDD:213211 142/220 (65%)
PDZ-binding 1322..1325
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151548
Domainoid 1 1.000 226 1.000 Domainoid score I2519
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H74563
Inparanoid 1 1.050 1102 1.000 Inparanoid score I233
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0001028
OrthoInspector 1 1.000 - - otm40263
orthoMCL 1 0.900 - - OOG6_100026
Panther 1 1.100 - - LDO PTHR24223
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5383
SonicParanoid 1 1.000 - - X771
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1413.940

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