DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and abcc9

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	XP_031754288.1	Gene:	abcc9 / 101733439	XenbaseID:	XB-GENE-6074535	Length:	1577	Species:	Xenopus tropicalis

Alignment Length:	1444	Identity:	445/1444 - (30%)
Similarity:	732/1444 - (50%)	Gaps:	224/1444 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NFISAACFWYTMPTFIKGRKRTLDTKDL------YRALKEHKSETLGNKLCASWELELEKTKGK- 75
            |.:|.|.:|:..|..|...||.:|.|.:      .|||..:.|      |..::|.:.:|...:
Frog   221 NLLSKATYWWMNPLIISAHKRPIDLKTIGKLPIAMRALTNYLS------LKTAYEEQKKKLVDRP 279

  Fly    76 ---PNLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLI--------------------- 116
               |::.:|:.|.||....|.....:|.:| |....|:.:..::
Frog   280 HKDPSIWKAIYRAFGRPILLSSTFRYLADL-LGFAGPLCISGIVQLLDSRNKGPTDQDFPKTNFS 343

  Fly   117 -AYYTHGSESIESAYYYAAGVILCSALNVIIMHPYMLG----TMHVGLKMRVGMCSMIYRKALRL 176
             .|:......||:  ||...|:|..||  |:...::..    |:..|:.:|..:.||||.|.|||
Frog   344 SVYFLSSKGLIEN--YYVLAVLLFLAL--ILQRTFLQASYYVTIETGINLRGALLSMIYNKILRL 404

  Fly   177 SKS--ALGDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFM 239
            |.|  ::|:.|.|.:.||::.:..:|.........||..|::.:....|:::.:|::|:.|.|.:
Frog   405 STSNMSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPIQIIMGVILLHKLVGVSALVGAAVI 469

  Fly   240 LLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINA 304
            :|..|:|.::..:.:.::..|...:.||::..|||:.||:::|:||||..|.:.|...|.||:.:
Frog   470 VLLAPMQYFIATKLAEVQKNTLDYSTERLKKTNEILKGIKLLKLYAWENIFCNSVEETRIKELKS 534

  Fly   305 IRHVSYIRGILLSFIIFLTRVSIFLSLVGYV--LLGTF----------LTPEVAFLITAYYNILR 357
            ::          :|.:. |.:|||::....:  :|.||          |||..||...:.::||.
Frog   535 LK----------TFALH-TSLSIFMNAAIPIAAVLATFVTHAYVSSSHLTPANAFASLSLFHILV 588

  Fly   358 TTMTVFFPQGISQMA-ETLVSIKRVQKYMQSDETNVMDMSVDLTED-FQGSNQET---------- 410
            |.:  |....:.:.| :.|||::::.::..|||         :.|| |:  |.||
Frog   589 TPL--FLLSTVVRFAVKALVSVQKLNEFFTSDE---------IREDGFR--NGETTLPFESCRKH 640

  Fly   411 --VHADGDEERDEAE---DKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRV 470
              :|:.....:....   ||....|...| ..:...:|.:.:.|....|.....  :|..:::::
Frog   641 PGIHSRAFNRKQPLRYQMDKYDQAPKRQV-RTSDTEDAALKVCGGFFSWGTGLA--TLANIDIQI 702

  Fly   471 QPGTMLGIVGRTGSGKSSLIQAILGELPAESGEI--------------KVNG------------- 508
            ..|.:..|||:.|.|||||:.|||||:....|.:              ..||
Frog   703 PTGELTMIVGQVGCGKSSLLLAILGEMQTLEGRVVWNKFGSQRRAPGSSANGWDSACGSERSKNR 767

  Fly   509 -SMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSG 572
             |::||.|:|||.:.|:.:||.||.|.:::||..|...|:|:.|.:||||.|:|.:||||.:|||
Frog   768 HSVAYAGQKPWLLNATLEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSG 832

  Fly   573 GQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRE--RIVILATHQLQFLQHA 635
            ||:.||.:|||:|:.|:|..||||.||:|.|::.||.::.:..:|||  |.|:|.||:||:|.||
Frog   833 GQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLREDKRTVVLVTHKLQYLPHA 897

  Fly   636 DQIVIMDKGRVSAVGTYESLRESGLDF------------ASMLADPERDEQSEERSRSRSGSYTH 688
            |.|:.|..|.|...||.:.::.:..:.            ..:..|.:.|:.:.||...|...|:.
Frog   898 DWIIAMKDGSVLREGTLKDIQNNDNELYEHWKTLMNRQDQELEKDSDADQVTMERKTLRRAMYSR 962

  Fly   689 SHSDQRRNSEQSLLSMADSCMDDLEAEQANNQERQEAGQIGLRLYSKY-------FKAGGGFFAF 746
            ....|....|                |:...::..|.....:||.:|:       :...||:...
Frog   963 EAKVQAEEEE----------------EEEEEEDEDETMSTAMRLRTKFPWRTCWRYLTSGGYLLL 1011

  Fly   747 FVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEM 811
            |:|:...:|...:....||:|:.|.::..|::|...:|.|:.||     ||:
Frog  1012 FLMIFSKLLKHSVIVAIDYWLASWTSETSNISYAQSDNVTSASE-----LSS------------- 1058

  Fly   812 LDTYI---FTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNR 873
            :.:|.   |:|::...|::.:..|.....:.:.|:..||:::.:.|..|.:.||:|.|.|.||||
Frog  1059 IQSYYVTGFSVLSATGIVLCLIASLTVEWMGLNAAKNLHHNLLKKIILAPIRFFDTTPLGLILNR 1123

  Fly   874 FSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDV 938
            ||.|...:|:.:|..:..:.:..|.....:.||:...|:.::..:.||:.||.::.::...|:|:
Frog  1124 FSADTNIIDQHIPPTLESLTRSTLLCLSAIGVISYATPISMVALLPLGVAFYFIQKYFRVASKDL 1188

  Fly   939 KRMEAITRSPVYSHLAASLTGLSTIRAFG-----AQRVLEAEFDNYQDMHSSAFYMFISTSRAFG 998
            :.::..|:.|:..|.:.:..||:|||||.     .||:||....|      :..|:|:|   |..
Frog  1189 QELDDSTQLPLLCHFSETAEGLTTIRAFRHEARFKQRMLELTDTN------NLAYLFLS---AAN 1244

  Fly   999 YWLDC------FCVIYIAIITLSFFIFPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTA 1057
            .||:.      .|::..|.:   |.|....:.|.|||.:|.|:.:|..:.|.:|..|:||..:.|
Frog  1245 RWLEVRTDYLGACIVLTAAV---FSITYGLDSGIVGLGLTYALTVTNYLNWVVRNLADLEVQIGA 1306

  Fly  1058 VERVVEYEDIEP---EGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKP 1119
            |::|..:.:||.   ||::|   .::.|:.||:.|:|...:|.:||..:.|.  |||.|...|||
Frog  1307 VKKVNSFLNIESECYEGSME---QQQVPEDWPQSGEIRISDLCVRYENNHKP--VLKHLKAYIKP 1366

  Fly  1120 KEKVGIVGRTGAGKSSLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTM 1183
            .:||||.||||:|||||..|.||: ...||.::||..|.|::.|:.|||::|||.|:|:||||::
Frog  1367 GQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLNTLRSRLSIILQDPILFSGSI 1431

  Fly  1184 RYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENR 1248
            |:||||..:.||::||..|:..:||.:|..||.||.:.:||||.|||||||||.|||||.:|.:.
Frog  1432 RFNLDPECKCSDERLWEGLDIAQLKNLVKALPGGLDAMVTEGGENFSVGQRQLFCLARAFVRNSS 1496

  Fly  1249 ILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYEL 1313
            ||:||||||::|..|:.::|..:...|.:.||:|||||:|||:..|..:||..|..:|..||..|
Frog  1497 ILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTGDVAIVMRRGNILEHDTPGNL 1561

  Fly  1314 LTLADSKVFHGMVK 1327
            |...|| :|...|:
Frog  1562 LAQEDS-IFASFVR 1574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	440/1430 (31%)
		ABC_membrane	107..360	CDD:294371	75/292 (26%)
		ABCC_MRP_domain1	445..645	CDD:213217	89/229 (39%)
		ABC_membrane	815..1014	CDD:294371	57/212 (27%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	111/221 (50%)
abcc9	XP_031754288.1	MRP_assoc_pro	222..1574	CDD:188098	443/1441 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9436
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010