Protein Alignment CG7627 and abcc8

DIOPT Version :9

• Sequence 1: NP_001245943.1
• Gene: CG7627 / 34148
• FlyBaseID: FBgn0032026
• Length: 1355
• Species: Drosophila melanogaster
• Sequence 2: XP_031756190.1
• Gene: abcc8 / 101730668
• -ID: -
• Length: 1580
• Species: Xenopus tropicalis
• Alignment Length: 1444
• Identity: 428/1444 - (29%)
• Similarity: 723/1444 - (50%)
• Gaps: 248/1444 - (17%)

  Fly    18 NFISAACFWYTMPTFIK-GRKRTLDTKD----------------LYRALKEHKSET----LGNK- 60
            |.:|...:|: |.|||| ..|:.:|.|.                |.:|....||::    .|.|
 Frog   223 NLLSKGTYWW-MNTFIKTAHKKPIDLKAIGKLPIAMRAVTNYLLLNKAFHSQKSKSSPCPAGPKS 286

  Fly    61 ----LCASWELELEKTKGKPNLLRALLRV------FGWYFALLGLVLFLLELGLRTL--QPIFLL 113
                ||.::        |:|.:|.::.|:      |.....:.|:|..|.:.. :|.  ||||
 Frog   287 IWFALCQAF--------GRPLILSSIFRIMADMLGFAGPLCISGIVHHLSQEN-KTFHPQPIF-- 340

  Fly   114 KLIAYYTHGSESIESAYYYAAGVILCSALNVIIMHPYMLGTMHV----GLKMRVGMCSMIYRKAL 174
             |..::....|.:.:||..|  |:|..||  ::...::..:.:|    |:.:|..:.:.||.|.:
 Frog   341 -LGVFFISSQEFLANAYVLA--VLLFFAL--LLQRSFLQASYYVAIETGINLRGAIQTKIYNKIM 400

  Fly   175 RLSKS--ALGDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVA 237
            .||.|  ::|:.::|.:.||::.|..:|.........||..|::.:....|:|..:||:|:.|..
 Frog   401 HLSTSNMSMGEMSSGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGISALIGAV 465

  Fly   238 FMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEI 302
            .:::..|:|.::..:.|..:..|...::||::..||::.||:::|:|:||..|...|...|:||:
 Frog   466 VIIVLAPIQYFVATKLSQAQRSTLEYSNERLKKTNEMLRGIKLLKLYSWEHIFHSSVEETRQKEM 530

  Fly   303 NAIRHVSYIRGILLSFIIFLTRVSIFLSL---VGYVLLGTFL-----------TPEVAFLITAYY 353
            |:::          :|.:: |.:|||::.   :..||: ||:           :|.|||...:.:
 Frog   531 NSLK----------AFALY-TSISIFMNAAIPIAAVLI-TFVVHVHLLHREQFSPAVAFASLSLF 583

  Fly   354 NILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEE 418
            :||.|.: ......:....:.|||::::.::..|:|..                 |.|.......
 Frog   584 HILVTPL-FLLSSVVRSTVKALVSVQKLSEFFSSEEIG-----------------EEVEKCPPSN 630

  Fly   419 RDEAEDKLLGPPIATVNENAKL--------------------SEAGISISGLMAKWDVNSPDYSL 463
            :...::|....|:..||....:                    :|..|.::.....|..:.|. :|
 Frog   631 KSVPQNKYQAVPLKVVNRKRPIRDDWNHFNSRQRGAPNPTEGNEFCIKVTSGFFTWTPDGPP-AL 694

  Fly   464 NGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVN--------------------- 507
            :.:::|:..|.:..|||:.|.|||||:.|.|||:...||::..|
 Frog   695 SSIDIRIPQGQLTMIVGQVGCGKSSLLLATLGEMHKISGDVSWNSTVPDSETGEDVNPDKETAID 759

  Fly   508 ------GSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGER 566
                  |:::||||:|||.:.||.:||.|..|.::::|..::..|:|:.|.::||..|:|.:|||
 Frog   760 VETRRRGAVAYASQKPWLLNATVEENITFESPFNKQKYKAIIDACSLQPDIDILPHGDQTQIGER 824

  Fly   567 GASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRE--RIVILATHQL 629
            |.:|||||:.|||:||.:|::||:..||||.||:|.|::.||..:.:...||:  |..:|.||:|
 Frog   825 GINLSGGQRQRISVARVLYQQTSVVFLDDPFSALDIHLSDHLMHEGILKMLRDNKRTTVLVTHKL 889

  Fly   630 QFLQHADQIVIMDKGRVSAVGTYESLRESGLDFASMLADPE----------RDEQSEER----SR 680
            |:|.|||.|:.|..|.:...||.:.:::|         |||          |.:|..|:    .|
 Frog   890 QYLPHADWIIAMKDGTIQREGTLKDIQKS---------DPELYEHWKTLMNRQDQELEKEIILDR 945

  Fly   681 SRSGSYTHSHSDQRRNSEQSLLSMADSCMDDLEAEQANNQERQE-----------AGQIGLRLYS 734
            ...|        :|.|..:::.. .|:.:.|.|.::....|.:|           ..::..|...
 Frog   946 KAGG--------ERMNLTRTIYP-RDALLGDDEEDEEEISESEEDDDNLSSVLHQRAKMPWRACG 1001

  Fly   735 KYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAY------RADNNDTTRSEELE 793
            ||..:.|     .:::...||||.|.......:.:|:.|..:.|.      ......|.|.:...
 Frog  1002 KYLSSAG-----ILLLPLLVLSQLLKHSVMVAIDFWLAKWTSAAITNLSVANCSGRPTCRFDHSP 1061

  Fly   794 PRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAA 858
            ..::                   |::::.:.|::.:|.|.......::.:.:||:|:...|..|.
 Frog  1062 YSMA-------------------FSILSCVGIIMCLATSIAVEWTGLRVAKKLHSSLLNAIILAP 1107

  Fly   859 MYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGII 923
            |.||.|.|.|.||||||.|...:|:.:||.:..:.:..|.....:.||:.|.|:|||..|.|.||
 Frog  1108 MRFFETTPLGSILNRFSADFNTIDQHIPATLECLSRSTLLCVSALAVISYVTPVFLISLVPLAII 1172

  Fly   924 FYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFG-----AQRVLEAEFDNYQDMH 983
            .|.::.::...|||::::|..|:.|:.||.|.::.||:|||||.     .|::||     :.|.:
 Frog  1173 CYFIQKYFRVASRDLQQLEDSTQLPLLSHFAETVEGLTTIRAFRYEPRFRQKLLE-----HTDSN 1232

  Fly   984 SSAFYMFISTSRAFGYWLDC------FCVIYI-AIITLSFFIFPPANGGDVGLAITQAMGMTGMV 1041
            :.|.....:.:|    ||:.      .||:.| |:.:::..:....:.|.|||.:|.|:.::..:
 Frog  1233 NIASLFLTAANR----WLEVRMEYIGACVVLIAAVASITNSLHYNLSSGLVGLGLTYALMVSNYL 1293

  Fly  1042 QWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKS 1106
            .|.:|..:::|..:.||:|:......|||......:..:.|.:|||.|:|....||:||  |...
 Frog  1294 NWMVRNLSDMEIQLGAVKRINGLLKTEPENYKGLLSPTQIPPNWPENGEIQIQNLSVRY--DSSL 1356

  Fly  1107 ENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKIS 1170
            :.|||.::..|.|.:|:||.||||:||||...|.||: ....|.::||..|.:::.|..|||::|
 Frog  1357 KPVLKHVNAHITPGQKIGICGRTGSGKSSFSLAFFRMVDTFQGRIIIDGIDIAKLPLQTLRSRLS 1421

  Fly  1171 IIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQ 1235
            ||.|:|:|||||:|:||||.::.:|..||.:||..:||.||..||.||.:.:||||.||||||||
 Frog  1422 IILQDPILFSGTIRFNLDPENKCTDAMLWEALEIAQLKHVVKVLPGGLDALVTEGGENFSVGQRQ 1486

  Fly  1236 LVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMD 1300
            |.|||||.:|::.||:||||||::|..|:.::|..:...|.:.||:|||||:|||:::|.|:||.
 Frog  1487 LFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFDDRTVVTIAHRVHTILNADLVIVMK 1551

  Fly  1301 AGRAVEFGTPYELL 1314
            .|..:|:..|..||
 Frog  1552 RGAIMEYDKPEALL 1565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	428/1444 (30%)
		ABC_membrane	107..360	CDD:294371	73/274 (27%)
		ABCC_MRP_domain1	445..645	CDD:213217	85/228 (37%)
		ABC_membrane	815..1014	CDD:294371	66/210 (31%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	109/221 (49%)
abcc8	XP_031756190.1	MRP_assoc_pro	224..1573	CDD:188098	427/1443 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9436
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010