DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and ABCC5

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_005679.2	Gene:	ABCC5 / 10057	HGNCID:	56	Length:	1437	Species:	Homo sapiens

Alignment Length:	1428	Identity:	469/1428 - (32%)
Similarity:	736/1428 - (51%)	Gaps:	193/1428 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSLKTADLPENPREHCNFISAACF-WYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCAS 64
            ::.::|....::|.::....|...| |.:....:..:|..|..:|::...|...|:....:|...
Human    88 LKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERL 152

  Fly    65 WELELEKTKGKPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQ----PIFLLKLIAYYTHGSES 125
            |:.||.:.......||.::    |.|....|:|.::.|.:..|.    |.|::|.:..||..:||
Human   153 WQEELNEVGPDAASLRRVV----WIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATES 213

  Fly   126 -IESAYYYAAGVILCSALNVIIMHPYMLG-----TMHVGLKMRVGMCSMIYRKALRLSKSALGDT 184
             ::.:.....|::|..     |:..:.|.     ....|:::|..:.:|.::|.|:|..  :.:.
Human   214 NLQYSLLLVLGLLLTE-----IVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKN--IKEK 271

  Fly   185 TAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREI--GIAAVFGVAFMLLFIPLQA 247
            :.|.::|:.|||..|:..|......|..||:  :.|..::|..|  |.....|.|..:||.|...
Human   272 SLGELINICSNDGQRMFEAAAVGSLLAGGPV--VAILGMIYNVIILGPTGFLGSAVFILFYPAMM 334

  Fly   248 YLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIR 312
            :..:.|:..|.:....|||||:.|||:::.|:.||||||...|...|...|::|...:....|.:
Human   335 FASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQ 399

  Fly   313 GILLSFIIFLTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVS 377
            .|.:.....:..::..::...::.||..||...||.:...:|.:...:.| .|..:..::|..|:
Human   400 SITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKV-TPFSVKSLSEASVA 463

  Fly   378 IKRVQKYMQSDETNVM-------------------------------DMSVDLTEDFQGSN---- 407
            :.|.:.....:|.:::                               .::..:.:|.:.|.
Human   464 VDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKE 528

  Fly   408 -----QETVH------------ADGDE----ERDEAEDKLLGPPIATVNENAKLSEAGISISGLM 451
                 |.|.|            .|.||    |.:|.:...||        :.:|..
Human   529 KVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLG--------HLRLQR--------- 576

  Fly   452 AKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQE 516
                      :|:.::|.:|.|.::||.|..||||:|||.||||::....|.|.::|:.:|.:|:
Human   577 ----------TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQ 631

  Fly   517 PWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLA 581
            .|:.:.|:|.|||||:..|..||..|:..|.|..|..:||..|.|.:|||||:|||||:.|||||
Human   632 AWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA 696

  Fly   582 RAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHADQIVIMDKGRV 646
            ||:|.:.|||:|||||||:|.||..|:|...:|.:|:.:.|:..|||||:|...|:::.|.:|.:
Human   697 RALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCI 761

  Fly   647 SAVGTYESLRESGLDFASML-------ADPERDEQSEERSRSRSGSYTHSHSDQRRNSEQSLLSM 704
            :..||:|.|.....|:|::.       ..|......:|.|.|:..|............|::
Human   762 TERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKA---- 822

  Fly   705 ADSCMDDLEAEQANNQERQEAGQ--IGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFL 767
                   ::.|:....:.:|.||  :...:|..|.:|.||..||.|:|...:|:.|..:...::|
Human   823 -------VKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWL 880

  Fly   768 SYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLD-------TYIFTVITVLTI 825
            |||: |:|     :.|...||..|             .||...|.|       ..|:.:...:.:
Human   881 SYWI-KQG-----SGNTTVTRGNE-------------TSVSDSMKDNPHMQYYASIYALSMAVML 926

  Fly   826 LVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILP---- 886
            ::...|..:|....::||.|||:.:||.|.|:.|.||:|.|:|||||||||||.:||..||
Human   927 ILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAE 991

  Fly   887 AVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYS 951
            ..:.:||.:|..:.    :||.|.|.||:....|.|:|..|........|::||::.||:||..|
Human   992 MFIQNVILVFFCVG----MIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLS 1052

  Fly   952 HLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCFCVIYIAIITLSF 1016
            |:.:|:.||:||.|:...:.....:....|.:.:.|::|....|.....||   :|.||:||.:.
Human  1053 HITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLD---LISIALITTTG 1114

  Fly  1017 FI-------FPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALE 1074
            .:       .|||.   .||||:.|:.:||:.|:.:|.::|.|...|:|||:..|....   :||
Human  1115 LMIVLMHGQIPPAY---AGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTL---SLE 1173

  Fly  1075 APA---DKKPPKSWPEQGKIVFDELSLRYTPDPKSEN---VLKSLSFVIKPKEKVGIVGRTGAGK 1133
            |||   :|.|...||::|::.|:...:||     .||   |||.:||.||||||:|||||||:||
Human  1174 APARIKNKAPSPDWPQEGEVTFENAEMRY-----RENLPLVLKKVSFTIKPKEKIGIVGRTGSGK 1233

  Fly  1134 SSLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDK 1197
            |||..||||| ..:.|.:.||....|::||.|||||:|||||||||||||:|.|||||::|::|:
Human  1234 SSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQ 1298

  Fly  1198 LWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQ 1262
            :|.:||...:||.:|.||..|:|::.|.|.|||||:|||:|:|||:||..:||::|||||.:|.:
Human  1299 IWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTE 1363

  Fly  1263 TDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGM 1325
            ||.|||.|||..|.:||:|||||||||::.||:::|:..|:.|||.||..||: .||..|:.|
Human  1364 TDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLS-NDSSRFYAM 1425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	463/1405 (33%)
		ABC_membrane	107..360	CDD:294371	67/264 (25%)
		ABCC_MRP_domain1	445..645	CDD:213217	86/199 (43%)
		ABC_membrane	815..1014	CDD:294371	70/202 (35%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	127/224 (57%)
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..41
		CFTR_protein	100..1430	CDD:273530	468/1416 (33%)
		ABC_membrane	<271..447	CDD:294371	49/177 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..538		4/36 (11%)
		ABCC_MRP_domain1	577..759	CDD:213217	86/181 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..827		5/43 (12%)
		ABC_membrane	863..1143	CDD:294371	98/308 (32%)
		ABCC_MRP_domain2	1191..1411	CDD:213211	127/224 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151528
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.660