DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and abcc12

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	XP_002937916.3	Gene:	abcc12 / 100493828	XenbaseID:	XB-GENE-6465370	Length:	1430	Species:	Xenopus tropicalis

Alignment Length:	1434	Identity:	461/1434 - (32%)
Similarity:	736/1434 - (51%)	Gaps:	161/1434 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ENPREHCNFISAACFWYTMPTFIKGRKRT-LDTKDLYRALKEHKSETLGNKLCASWELELEKTKG 74
            ::|.::....|.....:..|...|..|.: |...||:.......|||...:|.:.||.||: ..|
Frog    29 QHPIDNAGLFSFMTLNWITPLARKAYKLSELQMNDLWSLPFHESSETNCQRLQSLWEEELQ-NHG 92

  Fly    75 KPNLLRALLRVFGWYF----ALLGLVLFLLELGLRTLQP-IFLLKLIAYYTHGSESIESAYYYAA 134
            |   .:|.|.:..|.|    :||..:..::.:....:.| ||:..|:.|.......:......|:
Frog    93 K---RKASLSLVLWRFCRTRSLLAFLSLIITMTASFIGPAIFIRALLEYANTLKHDLRYGLILAS 154

  Fly   135 GVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVGR 199
            |:.....:.......:.......|::::..:.::.::|.|:|.:|  .|...|.::|:.|:|..|
Frog   155 GIFAAELVRSWSFALHWAMNYRTGVRLKGAVLALAFKKMLKLKQS--NDIRTGELLNMCSSDGQR 217

  Fly   200 LDLATIFVHYLWVGPLETLFITYLMYRE--IGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTAL 262
            |..|......|..||:  :.|..|:|..  :|.:|:.|.:..::|.|......|.|:..|.:..:
Frog   218 LFEAASIGCMLAAGPV--IGIMGLVYTALFLGPSALLGSSVFIIFYPFMMLASKLTAYFRKKCIV 280

  Fly   263 RTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFLTRVSI 327
            .||.|||:||||::.|:.|||||||..|.:.:...|.:|...:....|::.|.......:..|:.
Frog   281 VTDRRVRLMNEILNSIKFIKMYAWENTFRNKIQDIRSEEKTFLEKAGYVQSITSGVAPVVVVVAS 345

  Fly   328 FLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNV 392
            ..:...::.||..|....||.:...:|.: |:.....|..:...:|..:||.|.||....:|:::
Frog   346 VCTFTLHMALGYNLNAAEAFTVVTVFNSM-TSALKMIPLAVKAASEASISISRFQKLFLMEESDM 409

  Fly   393 MD----MSVDLTEDFQG---SNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGL 450
            .:    :|.||. ||.|   |....|.:...|::.|||.|.     ....|...|.......|..
Frog   410 RNNQRLLSNDLI-DFSGAYFSWSSDVRSSTLEKQKEAEQKQ-----EEFKETQNLINGHYLFSSS 468

  Fly   451 MAKWDVNSPDYS----------LNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIK 505
            .:|..||..:.|          |..:|..||...::||.|..||||:|||.:|||::....|.:.
Frog   469 ESKQIVNGTNASEYIVCEHKAALININFTVQKSKLIGICGSVGSGKTSLILSILGQMTLLEGTVT 533

  Fly   506 VNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASL 570
            |:|.::||:|:.|:|:.::|:|||||:....::|.:|:|.|.|..|.|.||..|.|.:||||.:|
Frog   534 VSGRIAYAAQQAWIFNESLRENILFGEEYKEKKYQRVLKTCCLYPDIESLPHGDLTEIGERGTNL 598

  Fly   571 SGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHA 635
            ||||:.|||||||:|.|.|:.||||||||||..|...||::.::..:..|||:..|||||:|...
Frog   599 SGGQRQRISLARALYSERSVVLLDDPLSAVDVQVGAQLFKKAIKHGMMNRIVLFVTHQLQYLVEC 663

  Fly   636 DQIVIMDKGRVSAVGTYESLRESGLDFA----------SMLAD----PERDEQ------------ 674
            |::::|..|.::..||:|.|.:...|:|          |:.:|    |.:.||
Frog   664 DEVLMMKNGSIAEQGTHEELMKYQGDYAVLFQSMQQVNSIKSDVQCSPMKYEQLDRQVTSSHHAT 728

  Fly   675 -----------SEERSRSRSGSYTH--------SHSDQRRNSEQSL-------LSMADSC---MD 710
                       ||..::..:|.:|.        :|..:..|.:..:       ...||..   .|
Frog   729 VVQQSKEQGTLSELTNQEETGHFTSEDVSADHLTHKSEMVNRDFMVTDGQITGCKQADQYGDQED 793

  Fly   711 DLEAEQ----------ANNQERQE----------AGQIGLRLYSKYFKAGGGFFAFFVMMGFCVL 755
            |.:.::          .||.|||.          .|.:...:|..|.||.||..       ||||
Frog   794 DADEDEKGSVLGNTIIVNNNERQNRDLMEPEEKGCGSVPCPIYWVYIKAAGGAL-------FCVL 851

  Fly   756 -------SQGLASLGDYFLSYWVTK-KGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEML 812
                   :.|..:..:::||||:.: .||.:. ..:|.|..|:.:.              |...|
Frog   852 NAVLFIFTTGSMAFSNWWLSYWIKQGSGNTSV-VTSNVTLSSDNMS--------------DNPDL 901

  Fly   813 DTYIFTVITVLTILV--TVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFS 875
            :.||:..|:.|..::  ...|.::|....:|||.:||:.:|:.:..:.:..|:|.|.|||||||:
Frog   902 EFYIYVYISTLAAVLGFRFIRGYVFVKSTLKASTKLHDQLFQKVLHSPLKLFDTTPLGRILNRFT 966

  Fly   876 KDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKR 940
            |||.:||..||..:..:||..:.:...:.:|:.|.|.||:..:.|.|:|:.:........|::||
Frog   967 KDMDEVDARLPCQLEQLIQNMILVLFCLGMISFVFPWFLVSVLPLSILFFLINKVSRVLIRELKR 1031

  Fly   941 MEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCFC 1005
            ::.|::||..||:.|||.|::||:|:.........|....|::....::|...||.....||...
Frog  1032 LDNISQSPFLSHVTASLHGITTIQAYNKNTDFILRFQKLLDINQVPCFLFSCASRWLAVRLDLIS 1096

  Fly  1006 VIYIAIITLSFFI----FPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEY-E 1065
            :|.|.:.::...:    .|||.   .||||:.|:.:||:.|:.:|...|.|...|:|||:..| :
Frog  1097 MIVITLTSVCIVLMHGHIPPAY---AGLAISYAVQLTGLFQYTVRLVTETEARFTSVERINHYIK 1158

  Fly  1066 DIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTG 1130
            ::|.|..|:  |.:..||:||::|.|.|:.:.:||.  .|...|||::||.|:||||:|||||||
Frog  1159 NLESEEPLK--AKEITPKTWPQEGAITFENVEMRYR--DKLPLVLKNISFSIRPKEKIGIVGRTG 1219

  Fly  1131 AGKSSLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYS 1194
            :|||||...|||| ....|||.||....:.:||.:||.|:|::||:||||.|::|.||||.:.::
Frog  1220 SGKSSLGMVLFRLVDLAGGSVTIDNFCINTIGLKNLRGKLSVLPQDPVLFVGSIRSNLDPLNLHT 1284

  Fly  1195 DDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANV 1259
            |:::|.:||...:|:.|:.|...|..:::|.|:|||||:|||:|:|||:||.:::|::|||||.:
Frog  1285 DEEVWNALERTHMKQHVSKLVGKLNYEVSENGSNFSVGERQLLCMARALLRSSKVLLLDEATAAI 1349

  Fly  1260 DPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHG 1324
            |.:||.|||.|::..|.:||||.|||||:||:..|:::|||.|:.|||..|..||:...|: ||.
Frog  1350 DNETDALIQETVKEAFHDCTVLIIAHRLNTILHCDRIMVMDKGKIVEFEKPSVLLSNKKSR-FHA 1413

  Fly  1325 MVKQ 1328
            |..|
Frog  1414 MATQ 1417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	455/1418 (32%)
		ABC_membrane	107..360	CDD:294371	64/255 (25%)
		ABCC_MRP_domain1	445..645	CDD:213217	90/209 (43%)
		ABC_membrane	815..1014	CDD:294371	63/200 (32%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	112/221 (51%)
abcc12	XP_002937916.3	MRP_assoc_pro	27..1415	CDD:188098	459/1430 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010