Protein Alignment CG7627 and abcc4

DIOPT Version :9

• Sequence 1: NP_001245943.1
• Gene: CG7627 / 34148
• FlyBaseID: FBgn0032026
• Length: 1355
• Species: Drosophila melanogaster
• Sequence 2: XP_002939329.2
• Gene: abcc4 / 100491006
• XenbaseID: XB-GENE-957302
• Length: 1324
• Species: Xenopus tropicalis
• Alignment Length: 1364
• Identity: 605/1364 - (44%)
• Similarity: 873/1364 - (64%)
• Gaps: 91/1364 - (6%)

  Fly    12 NPREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTKG-- 74
            ||.:|.||.|...||:..|.||.|.||.|:..|:|..|.|..|..||.:|...||.||:|.:.
 Frog    11 NPSQHANFCSKIFFWWLNPLFILGHKRKLEEDDMYEVLPEDASRKLGEELQWYWEKELQKAQNEG 75

  Fly    75 -KPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYY----THGSESIESAYYYAA 134
             ||.|.:|::|.....|::|||..| .|..:|.:|||||..:|:|:    .:.|..:.:||..||
 Frog    76 RKPRLTKAIIRCHWKTFSVLGLFTF-FEESIRVVQPIFLGNVISYFERYDANDSAVLANAYINAA 139

  Fly   135 GVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVGR 199
            .:..|:.:..::.|.|....:..|:|:||.||.||||||||||.:|:|.||.|.:|||:||||.:
 Frog   140 ALSACTLILAVVHHIYFYHLLRAGMKLRVAMCHMIYRKALRLSNTAMGKTTTGQIVNLLSNDVNK 204

  Fly   200 LDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTALRT 264
            .|..|||:|:||.|||:.:.:|.|::.|||.:.:.|:|.:::.:|||..|||..:.||.:||..|
 Frog   205 FDQVTIFLHFLWAGPLQAIAVTVLLWMEIGPSCLAGMAVLIILMPLQLCLGKFFTSLRGKTAAFT 269

  Fly   265 DERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFLTRVSIFL 329
            |.|:|.|||:|||:::|||||||..|..:|...||||||.:...||:|.:.|:.....:::.:|:
 Frog   270 DTRIRTMNEVISGMRIIKMYAWEQSFTELVNNIRKKEINKVLRSSYLRALNLASFFVASKIILFV 334

  Fly   330 SLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMD 394
            :...|||||..::....|:..:.|:.:|.|:|:|||..:.:.:|..|||:|::.::..||  :..
 Frog   335 TFTTYVLLGNVISASRVFVAVSLYSAVRLTVTLFFPSAVERASEAKVSIRRIKNFLLLDE--IFK 397

  Fly   395 MSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSP 459
            .:::|.|                   |.|:.||                 :.|..:...||....
 Frog   398 PALELPE-------------------ENEENLL-----------------VQIQDVTCYWDKTLE 426

  Fly   460 DYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTV 524
            ..:|..::..|:||.:|.::|..|:|||||:.|:|||||.:.|.:.:.|.::|.||:||:|||||
 Frog   427 IPTLQNISCSVRPGELLAVIGPVGAGKSSLLSAVLGELPKDKGFVDIRGRIAYVSQQPWVFSGTV 491

  Fly   525 RQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETS 589
            |.|||||:...:.:|.||::.|||::|...|...|.||:|:||.:||||||||::||||||::..
 Frog   492 RSNILFGKEYVQEKYDKVLRVCALKKDMLQLDDGDLTIIGDRGVTLSGGQKARVNLARAVYQDAD 556

  Fly   590 IYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYES 654
            ||||||||||||..|.|||||:|:...||:::.||.|||||:|..|.||:|:.:||:...||::.
 Frog   557 IYLLDDPLSAVDAEVGRHLFEKCICQALRKKLCILVTHQLQYLSAAKQILILKEGRMVGKGTFQE 621

  Fly   655 LRESGLDFASMLADPERDEQSEERSRSRSGSYTHSHSDQRRNSEQSLLSM-------ADSCMDDL 712
            |.:||:||||:|...|     ||:|:|:.|....| |..|..|:.|:.|.       .:...|:|
 Frog   622 LLQSGIDFASLLKSEE-----EEQSQSQEGQLIKS-SRNRTFSQSSVWSQDSTVQSHKEGATDNL 680

  Fly   713 EAE---QANNQERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKK 774
            .||   .|..:|.:..|.:|.::|.|||.:|..:...||::...:|||....|.|::||||..::
 Frog   681 AAEPVLTAIPEESRSEGTVGFKVYKKYFTSGSSYLMLFVVLLLNILSQVTYVLQDWWLSYWANEQ 745

  Fly   775 GNVAYRADNNDT-TRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNL 838
            |.:...:..|.| :::|:|:  |:.:|.              ::..:||.||:..|.|..|.|::
 Frog   746 GKLNITSGTNSTGSKTEQLD--LTLYLG--------------VYAGLTVATIIFGVLRCLLVFHV 794

  Fly   839 AMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIV 903
            .:.|:..|||.||:.:.:|.:.||:.||.||||||||||:|.:|:::|...:|.:|:.|.:.|::
 Frog   795 LVCAAQALHNQMFQSLLKAPVLFFDRNPIGRILNRFSKDIGHLDDLMPFTFLDFMQVLLQILGVI 859

  Fly   904 IVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGA 968
            .|...|.|..|||.:.|.|:||.||.::|.||||:||:|:.|||||:|||::||.||.|||||.|
 Frog   860 AVAVAVIPWILIPLLPLVIVFYFLRRYFLDTSRDIKRLESTTRSPVFSHLSSSLQGLWTIRAFKA 924

  Fly   969 QRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCFCVIY-IAIITLSFFIFPPANGGDVGLAIT 1032
            ::..:..||..||:||.|:::|::|||.....||..|.:: |||...|..:....:.|.||||::
 Frog   925 EKRFQDLFDAQQDLHSEAWFLFLTTSRWLAVRLDAICAVFVIAIAFGSIILAENLDAGQVGLALS 989

  Fly  1033 QAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDELS 1097
            ..|.:.|..|||:|||||:||.|.:.|||:||..:|.|...|  :...||..||.:|.|.|:.::
 Frog   990 YGMTIMGSFQWGVRQSAEVENLMISAERVMEYTQLEKEAEWE--SKNPPPADWPNKGMITFENVN 1052

  Fly  1098 LRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSVLIDKRDTSEMGL 1162
            ..|:.|  ...||:.|:.:|:|||||||||||||||||||.|||||:..:|.:.|||..||::||
 Frog  1053 FSYSLD--GPVVLRHLNALIRPKEKVGIVGRTGAGKSSLIAALFRLAEPEGKIWIDKYLTSKLGL 1115

  Fly  1163 HDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGT 1227
            ||||.|:||||||||||:||||.|||||||::|::||..||||:|||.|.:||..::::::|.|:
 Frog  1116 HDLRKKMSIIPQEPVLFTGTMRKNLDPFDEHADEELWDVLEEVQLKEAVEELPGKIETQLSESGS 1180

  Fly  1228 NFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMD 1292
            ||||||||||||||||||.||||::|||||||||:||.|||.|||.||.|||||||||||:||:|
 Frog  1181 NFSVGQRQLVCLARAILRRNRILIIDEATANVDPRTDELIQKTIREKFAECTVLTIAHRLNTIID 1245

  Fly  1293 SDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTGHATYESLLKIAQKAF------ENRQN 1350
            |||::|:||||..|:..||.||...:| :|:.||:|.|.|...:|.:.|::.:      ||.:|
 Frog  1246 SDKIMVLDAGRVKEYDEPYLLLQNKES-LFYKMVQQVGKAEATALNEAAKQVYLKKIHQENTKN 1308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	592/1321 (45%)
		ABC_membrane	107..360	CDD:294371	108/256 (42%)
		ABCC_MRP_domain1	445..645	CDD:213217	100/199 (50%)
		ABC_membrane	815..1014	CDD:294371	91/199 (46%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	146/220 (66%)
abcc4	XP_002939329.2	PLN03130	2..1289	CDD:215595	600/1343 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	225	1.000	Domainoid score	I2471
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1027	1.000	Inparanoid score	I277
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm47437
Panther	1	1.100	-	-	LDO	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5383
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190