DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7627 and tap1

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	XP_002665053.1	Gene:	tap1 / 100333043	ZFINID:	ZDB-GENE-050517-43	Length:	731	Species:	Danio rerio

Alignment Length:	651	Identity:	152/651 - (23%)
Similarity:	301/651 - (46%)	Gaps:	94/651 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   717 ANNQERQEAGQIGLRLYSKYFKAGGGFFA---FFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVA 778
            |..:..::.|:..|:....|.|...|.||   |||:         ::|||:..:.::..|
Zfish   135 AKKERTEKKGKASLQRLLGYMKPFSGRFAAVFFFVV---------ISSLGEMAIPHYTGK----- 185

  Fly   779 YRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSF--LFFNLAMK 841
                             ::.|:    ::.|......:..||:|::||:..|....  |.:|:.|.
Zfish   186 -----------------MTDWI----MNEDEPEAFNHAITVMTLMTIMSAVCEFVCDLIYNITMS 229

  Fly   842 ASIRLHNS----MFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILP---AVMMDVIQIFLAL 899
               |:|.|    :|:.:.:..:.||:...:|.|::|.:.|...:.|.|.   :::|......:.|
Zfish   230 ---RIHTSIQGLVFQAVLKQDIAFFDKATTGDIVSRITTDTNTMSESLSEKLSLLMWYFMRVIFL 291

  Fly   900 AGIVIVIAVVNPLF-LIPTVVLGIIFYQLRTFYLKTSRDV-----KRMEAITRSPVYSHLAASLT 958
            .|.:::::.....| |:...|:.||......||.|.|..|     |..|..|.         :.:
Zfish   292 FGSMLMLSTRLCCFTLLGLPVIWIIPEIFGRFYQKLSAQVQDSLAKANEVATE---------TFS 347

  Fly   959 GLSTIRAFGAQRVLEAEFDNYQDMHSSAFYM--FISTSRAFGYWLDCFCVIYIAIITLSF----F 1017
            .:.|:|:|..:   :.|.:.|:......|.:  ..:.:.|...|.:....:.:.:..|.:    .
Zfish   348 SMKTVRSFANE---DGETERYRKCLEDTFALNKVEAAAYAVSTWTNSMSSLALKVSILYYGGRLV 409

  Fly  1018 IFPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEY----EDIEPEGALEAPAD 1078
            .....:.||:...:...:..|..|:..|.....::..:.|.|::.||    .|:.|:|:| ||..
Zfish   410 TGSDVSSGDLVSFVLYELQFTSAVEVLMSYWPHVKKAVGASEKIFEYVDRKPDVPPDGSL-APKT 473

  Fly  1079 KKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL 1143
            .|        |.:.|..::..|...|.:: |||::|..:|..:...:||.:|:||:::::.|.|.
Zfish   474 LK--------GHVQFRNVTFAYPKRPDTD-VLKNVSLELKAGKITALVGPSGSGKTTVVSLLERF 529

  Fly  1144 -SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDE-YSDDKLWRSLEEVK 1206
             ...:|.:|:|::.........|..|||::.||||||:.::|.|:....| .::::::.:.....
Zfish   530 YQPQNGEILLDQKPLLSYKDQYLHEKISVVSQEPVLFARSVRENIKYGKENATNEEIYAAARLAN 594

  Fly  1207 LKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTI 1271
            ..:.::.||.|..:...|.|...|.||:|.:.:|||::::.:|||:|:||:::|.:::..:.:.:
Zfish   595 AHDFISSLPKGYDTDAGEKGGQVSGGQKQRIAIARALIQKPQILVLDDATSSLDTESEHRVYSAL 659

  Fly  1272 RNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHG-MVKQTGHATYE 1335
            :.:.:.||||.|:|||..:.::|.:|.:..|..||.|...:||   |.:.|:. .|||...|.:.
Zfish   660 KKELQSCTVLLISHRLSGVENADHILFLREGELVEEGNHQQLL---DKQGFYAEFVKQQNTAIHR 721

  Fly  1336 S 1336
            :
Zfish   722 N 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	145/627 (23%)
		ABC_membrane	107..360	CDD:294371
		ABCC_MRP_domain1	445..645	CDD:213217
		ABC_membrane	815..1014	CDD:294371	45/215 (21%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	65/222 (29%)
tap1	XP_002665053.1	3a01208	42..712	CDD:273363	148/639 (23%)
		ABC_membrane	166..433	CDD:279056	58/316 (18%)
		P-loop_NTPase	467..692	CDD:304359	67/234 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000