DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and abcc8b

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	XP_021323602.1	Gene:	abcc8b / 100329706	ZFINID:	ZDB-GENE-120215-45	Length:	1607	Species:	Danio rerio

Alignment Length:	1427	Identity:	430/1427 - (30%)
Similarity:	717/1427 - (50%)	Gaps:	177/1427 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NFISAACFWYTMPTFI-KGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEK----TKGKPN 77
            |.:|.:.:|: |.||| ...:|.:|.|.:.:..|..::.:...:|..:::.::|.    .:|...
Zfish   238 NLLSKSTYWW-MNTFITSAHQRPIDLKTIGKLPKSMRALSNFQQLRKAFDSQMESGCVHLQGSGW 301

  Fly    78 LLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYTH------------GSESIESAY 130
            :.|||.:.||....|.....|:.:| |....|:.:..::.:.:.            |...|.|..
Zfish   302 MWRALRQAFGAPLLLSICFRFISDL-LGFAGPLCISGILQHISRDNHTAPPPVKLLGVHFISSEV 365

  Fly   131 YYAAGVILCSA--LNVIIMHPYMLGTMHV----GLKMRVGMCSMIYRKALRL--SKSALGDTTAG 187
            ::|...:|...  |.:::...::..:.:|    |:.:|..:.:.||.|.:||  |..::||.|..
Zfish   366 FFANAYVLAVLLFLALLLQRTFLQASYYVAIENGINLRGAVQTKIYNKIMRLCTSNMSMGDMTTA 430

  Fly   188 HVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKR 252
            .:.||::.|..:|.........||..|::.:....|:|..:|.:|:.|...:.:..|||.::..|
Zfish   431 QICNLVARDTNQLMWFFFLCPNLWAMPVQIVIGVLLLYYLLGASALIGATVITVLAPLQYFVATR 495

  Fly   253 TSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLS 317
            .|..:..|...|.||::..||::.||:::|:||||..|...|...|::|:.::|          :
Zfish   496 LSRAQKSTLEYTSERLKKTNELLRGIKLLKLYAWEHIFRSSVEETRRQELTSLR----------T 550

  Fly   318 FIIFLTRVSIFLS-----------LVGYVLLGT----FLTPEVAFLITAYYNILRTTMTVFFPQG 367
            |.:: |.:|||::           .|.:|.|.:    .|:|.|||...:.::||.|.: ......
Zfish   551 FALY-TSLSIFMNAAIPIAAVLTIFVVHVHLQSSSDFALSPAVAFGSLSLFHILVTPL-FLLSSV 613

  Fly   368 ISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHA----------------DGD 416
            :....:.|||::::.:::.|.|.......:..|......|.::|:|                |.:
Zfish   614 LHSTVKALVSVQKLSEFLSSAEIETDQDPIAQTPANNNGNIKSVYALQLQAKLVNRKNKAKQDVN 678

  Fly   417 EERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGR 481
            ...::.:.:|........|...|:      ::|..: |....|  :|..::::|..|.:..|||:
Zfish   679 RNFEQQDQELRASAQHEDNICIKI------VNGYFS-WTQGCP--TLTNIDIKVPFGQLTMIVGQ 734

  Fly   482 TGSGKSSLIQAILGELPAESGEIKVN-------------------------GSMSYASQEPWLFS 521
            .|||||||:.|.|||:...||.|..|                         ||::||||.|||.:
Zfish   735 VGSGKSSLLLAALGEMQKISGSITWNSLPRSDSDENIRAHDMSGRQSFTRRGSVAYASQRPWLLN 799

  Fly   522 GTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGER----GASLSGGQKARISLAR 582
            .||.:||||....:.:||..|::.|.|..|.:.||..|:|::|||    |..|||||:.|||:||
Zfish   800 ATVEENILFDTAPNVKRYKDVIEVCQLGPDIDTLPQGDQTVIGERVRHLGIILSGGQRQRISVAR 864

  Fly   583 AVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRE--RIVILATHQLQFLQHADQIVIMDKGR 645
            |:|::|::..||||.||:|.|::.||..:.:..:||:  |.|:|.||:||:|.|||.|:.|..|.
Zfish   865 ALYQQTNVVFLDDPFSALDIHLSDHLMHEGILKFLRQEKRSVVLVTHKLQYLPHADWIIAMRDGT 929

  Fly   646 VSAVGTYESLRESGLDFASMLADPERDEQSEERSRSRSGSYTHSHSDQRRNSEQSLLSMADSCMD 710
            |...||.:.::         .|:||..||  .|:........:|...:|::..::::...|:...
Zfish   930 VQTQGTLKDIQ---------CAEPELFEQ--WRTLMNRQDKENSTELKRKSFRRAMMYSRDTVAT 983

  Fly   711 DLEAEQA--------NNQERQEAGQIGLRL----------YSKYFKAGGGFFAFFVMMGFCVLSQ 757
            |.|.|.|        ::....:...:|..|          ::.|.||.|.|     ::...::||
Zfish   984 DDEDEVADVAVSEVKDSSTSTDEDSLGAELRHRTTIPWSSFATYLKAAGLF-----LLPLLIVSQ 1043

  Fly   758 ----GLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFT 818
                .|....|::|::|.:          :....:||..| |..|:.:|   .|.:......:|.
Zfish  1044 LAKHSLMVAIDFWLAHWTS----------DVIAAQSESAE-RNCTFTKD---CVFSHSWYLQVFC 1094

  Fly   819 VITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDE 883
            ::..|.|::.:..|.......::.:..||.|:.|.|..|.|..|.|.|.|.||||||.|...:|:
Zfish  1095 LLCALGIVLCLVTSLAVEWTGLRVAKELHCSLLRIIVLAPMRLFETTPLGNILNRFSTDTNTIDQ 1159

  Fly   884 ILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSP 948
            .:|..|..:.:..|.....|.||:.|.|:|||..:.|.:..|.::.::...|||::::|..|..|
Zfish  1160 HIPVTMECLSRSTLLCVSAVGVISYVTPVFLIALLPLTVACYFIQKYFRVASRDLQQLEDSTEMP 1224

  Fly   949 VYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLD-------CFCV 1006
            :.||.:.::.||:|||||..::..:.:...:.|.::.:.....:.:|    ||:       ...|
Zfish  1225 LLSHYSQTIEGLTTIRAFRHEQRFKKKLLEHTDANNISSLFLTAANR----WLEVRMEYIGALVV 1285

  Fly  1007 IYIAIITLSFFIFPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEG 1071
            :..|:.:::..::...:.|.|||.:|.|:.::..:.|.:|..|::|..:..|:||......:||.
Zfish  1286 LIAAVASITNALYRQLSAGLVGLGLTYALMVSNYLNWIVRNLADMEVQLGCVKRVSGLIHTQPES 1350

  Fly  1072 ALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSL 1136
            ........:.|..||:.|:|....||:||  |...:.|||.:|..|:|.:||||.||||:||||.
Zfish  1351 YDNIMTPAQVPAGWPKYGEIQIQNLSVRY--DSSLKPVLKHVSAHIRPGQKVGICGRTGSGKSSF 1413

  Fly  1137 INALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWR 1200
            ..||||: ...:|.:.||..|.|::.|..||||.|||.|:|:|||||:|:||||..:.:|:.||.
Zfish  1414 SLALFRMVDTFEGQISIDGIDISKLPLQTLRSKFSIILQDPILFSGTIRFNLDPERKATDEMLWE 1478

  Fly  1201 SLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDG 1265
            :||..:|..||..||.||.:.:||||.|||.|||||.|||||.:|::.||:||||||::|..|:.
Zfish  1479 ALEIAQLMPVVKALPGGLDAVVTEGGENFSQGQRQLFCLARAFVRKSSILIMDEATASIDMATES 1543

  Fly  1266 LIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVK 1327
            ::|..:...|.:.||:|||||:|||:.||.|:||..|..:|:..|..||...|| ||...|:
Zfish  1544 ILQKVVMTAFADRTVVTIAHRVHTILGSDVVIVMKHGGIIEYDEPDVLLEQKDS-VFSAFVR 1604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	424/1413 (30%)
		ABC_membrane	107..360	CDD:294371	70/287 (24%)
		ABCC_MRP_domain1	445..645	CDD:213217	91/230 (40%)
		ABC_membrane	815..1014	CDD:294371	57/205 (28%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	113/221 (51%)
abcc8b	XP_021323602.1	SunT	239..1600	CDD:331423	427/1420 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586039
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.650