DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and abcc10

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_001135594.1	Gene:	abcc10 / 100216149	XenbaseID:	XB-GENE-6465377	Length:	1501	Species:	Xenopus tropicalis

Alignment Length:	1334	Identity:	454/1334 - (34%)
Similarity:	691/1334 - (51%)	Gaps:	179/1334 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 KLCASWELELEKTKGKPNLLRALLRV---FGWYFALLGLVLFLLELGLRTLQ---PIFLLKLIAY 118
            ::|..::     :|....:||.|..:   ||..:..||    ||:||..||.   |:.|..|:.:
Frog   268 RICQHFQ-----SKSSSTILRLLPTLHASFGARYYALG----LLKLGAVTLAFLGPLLLNLLVNF 323

  Fly   119 YTHGSESIESAYYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGD 183
            .....|.:.....|..|:.....|..::.:.:......:.|.:|..:.:.:||||:|...:.|..
Frog   324 MEAADEPLSWGILYTLGLFSSCFLAALLQNQFTHEVNKLILAVRASVLTSVYRKAIRGVGTGLAG 388

  Fly   184 TTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAY 248
            .:.|.:||.||.|..|:.......|.:|..||:.....||:|.::|||.:.|:...:|.:|:...
Frog   389 FSKGEIVNFMSTDADRISNFCRSFHEVWSLPLQFSVTLYLLYLQVGIAFLGGLGLAVLLLPINKV 453

  Fly   249 LGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRG 313
            :..|............|.||::|.|::||::|:|.|.||..|...|...|:||:.::|.:..:..
Frog   454 IANRIVDYNSDLLNHKDARVKLMTELLSGMRVVKFYTWEKHFAEAVTSLREKELRSLRALKMLDA 518

  Fly   314 ----------ILLSFIIFLTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGI 368
                      :|:|.|.|:|          |||||..||....|...|...:|...:. .||..:
Frog   519 VCVYLWAALPVLISIITFIT----------YVLLGHQLTAAKVFTALALVGMLILPLN-NFPWVL 572

  Fly   369 SQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIAT 433
            :.:.|..||::|:|.:|...|.::::.          .:||                   || |.
Frog   573 NGVLEAKVSLERIQLFMDLPEQDLLNY----------YSQE-------------------PP-AD 607

  Fly   434 VNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELP 498
            .:...:|..|..|   .|.:...:|....|...:|.||.|.::|:||:.|.|||||:.|:.|||.
Frog   608 PSSALELRSAAFS---WMPEESEDSGSLQLFIEHLSVQKGVLVGVVGKVGCGKSSLLAALTGELS 669

  Fly   499 AESGEIKVNG---SMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDK 560
            ...||:..:.   ...:|:||||:...|:|:|||||:..:.:.|..|::.|||..|..:||..|:
Frog   670 RSGGELFASHQELGFGFAAQEPWIQFATIRENILFGKEFNGKLYQGVLEACALNDDLSILPSGDQ 734

  Fly   561 TIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILA 625
            |.|||.|.:||||||||::||||||::..||||||||:|||..||.||.|:|:.|.|:.:..||.
Frog   735 TEVGENGVTLSGGQKARLALARAVYQDKDIYLLDDPLAAVDADVAAHLMEKCILGILKNKTRILC 799

  Fly   626 THQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLDFASMLADPERDEQSEERSRSRS--GSYTH 688
            ||:.:.|..||.:::|:.|::...||                 |::.....|.||:|.  |....
Frog   800 THRTELLDKADIVLLMEGGKMVGSGT-----------------PDKILPLVESSRNRGSRGQTQM 847

  Fly   689 SHSDQRRNSEQSLLSMADSCMDDLEAEQANN----------QERQEAGQIGLRLYSKYFKAGGGF 743
            :|..|.  :||||..      |:.|||...|          ||.::.|.:.|::|..|:||.||.
Frog   848 NHISQA--AEQSLEE------DEEEAENEGNPIQPITAEVGQEEKQEGAVALQVYWAYWKAVGGC 904

  Fly   744 FAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELE-------PRLSTWLR 801
            .|..|::.. .|.|...::.|::||:|::..         .|:.|:..|.       |..|..|.
Frog   905 LAGSVLLAL-FLMQASRNISDWWLSHWISSL---------QDSPRNVSLTNLTPSSFPSASLLLF 959

  Fly   802 DIGLSV-------DAE---MLD-TYIFTV---ITVLTILVTVARSFLFFNLAMKASIRLHNSMFR 852
            ..|..|       .||   .|| |:..:|   |.|...:.|..|:|||....:.|::.:|..:..
Frog   960 SQGGLVSPISSVHSAEKNSSLDITFYLSVYGGIAVANSIFTALRAFLFALGTVHAAVVIHRRLLS 1024

  Fly   853 GITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLA----LAGIVIVIAVVNPLF 913
            .:.:|.:.||::.|.|||:||||.|:..||:.||.    |:.||||    |.|::::|:...|..
Frog  1025 SVLQATVSFFDSTPIGRIINRFSSDLYCVDDSLPF----VLNIFLAFTFGLLGMLVMISYGLPWI 1085

  Fly   914 LIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDN 978
            |...:.|.:::|.|:.||..:||::||:::||.||:|:|.:.:||||:||||.......|||..:
Frog  1086 LPVLLPLCLLYYYLQRFYRHSSRELKRLQSITLSPIYTHFSETLTGLTTIRATRHADRFEAECVS 1150

  Fly   979 YQDMHSSAFYMFISTSRAFGYWLD----CFCVIYIAIITLSFFIFPPANGGD---VGLAITQAMG 1036
            ..:::....:    .|.|...|||    ...|:.:|.|::...|......||   ||||::.|:.
Frog  1151 RLEVNQRCMF----ASNAAVQWLDIRLQMIGVMVVAAISVIAIIQHQRKSGDPGLVGLALSYALS 1211

  Fly  1037 MTGMVQWGMRQSAELENTMTAVERVVEYEDIEP----EGALEAPADKKPPKSWPEQGKIVFDELS 1097
            :||::...:....:.|..|.:|||..||....|    ||:|:...|      ||..|.|.|..:.
Frog  1212 ITGILSGLISSFTQTEAMMVSVERTEEYSTTLPSESAEGSLQVELD------WPTNGHIEFRNVV 1270

  Fly  1098 LRY---TPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVLIDKRDTS 1158
            |.|   .|     |.|..:||.|.|.||:|||||||:|||:|..|||| :...:||:|||...:.
Frog  1271 LCYRLGLP-----NALDGISFTISPGEKIGIVGRTGSGKSTLFLALFRMMELKEGSILIDNVPSH 1330

  Fly  1159 EMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKIT 1223
            .:.|..|||:::||||:..||||::|.||||...::|.::.:.|::..|::||..: .||.:.:.
Frog  1331 LLNLELLRSRLAIIPQDAFLFSGSVRVNLDPLSYHTDVEILKVLDQCHLQDVVRRI-GGLDADVG 1394

  Fly  1224 EGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLH 1288
            :.|.|||:|||||:|||||:|...:||.:|||||:||.|||.|:|.|||.:|:|.|||||||||:
Frog  1395 DRGKNFSLGQRQLLCLARALLTHAKILCIDEATASVDHQTDELLQRTIRERFRERTVLTIAHRLN 1459

  Fly  1289 TIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVF 1322
            ||||||:||||.||:.||..:|..|....||..:
Frog  1460 TIMDSDRVLVMHAGKLVELDSPANLSKREDSNFY 1493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	452/1325 (34%)
		ABC_membrane	107..360	CDD:294371	70/265 (26%)
		ABCC_MRP_domain1	445..645	CDD:213217	90/202 (45%)
		ABC_membrane	815..1014	CDD:294371	70/209 (33%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	115/224 (51%)
abcc10	NP_001135594.1	MRP_assoc_pro	180..1484	CDD:188098	451/1323 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920