Protein Alignment CG7627 and abcc5

DIOPT Version :9

• Sequence 1: NP_001245943.1
• Gene: CG7627 / 34148
• FlyBaseID: FBgn0032026
• Length: 1355
• Species: Drosophila melanogaster
• Sequence 2: XP_012818083.1
• Gene: abcc5 / 100125060
• XenbaseID: XB-GENE-986260
• Length: 1437
• Species: Xenopus tropicalis
• Alignment Length: 1412
• Identity: 470/1412 - (33%)
• Similarity: 739/1412 - (52%)
• Gaps: 187/1412 - (13%)

  Fly    11 ENPREHCNFISAACF-WYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTKG 74
            ::|.::....|...| |.|....|..:|..|..:|:: .|.:|:|..:.:|......||....||
 Frog    99 QHPVDNAGLFSFMTFSWLTPMARIAYKKGELFFEDIW-PLSKHESSDINSKRLEKLWLEEVTEKG 162

  Fly    75 KPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQ----PIFLLKLIAYYTHGSESIESAYYYAAG 135
            ..   .:.||...|:|....|::.::.|.|..|.    |.|::|.:..||..| |.:..|    .
 Frog   163 AD---ESSLRSVVWHFCRTRLIISIMCLMLTQLAGFIGPAFVVKSLLEYTQQS-SKDPGY----S 219

  Fly   136 VILCSALNVI-IMHPYMLG-----TMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMS 194
            ::|..||.:. |:..:.|.     ....|.::|..:.:|.::|.|:|..  :.:.:.|.::|:.|
 Frog   220 LLLVFALLMTEIVRSWSLALTWALNYRTGSRLRGAVLTMAFKKILKLKN--IKEKSMGELINVCS 282

  Fly   195 NDVGRLDLATIFVHYLWVGPLETLFITYLMYREI--GIAAVFGVAFMLLFIPLQAYLGKRTSVLR 257
            :|..|:..|......|..||:  :.|..::|..|  |.....|.|..:||.|...::.:.|:..|
 Frog   283 SDGQRMFEAAAVGSLLAGGPI--VAILGMIYNVIILGPTGFLGSAVFILFYPAMMFVSRLTAYFR 345

  Fly   258 LRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFL 322
            .:....|||||:.|||:::.|:.||||||...|...|...|:.|.:.:....|.:.|.:.....:
 Frog   346 RKCVSVTDERVQKMNEVLNYIKFIKMYAWVKAFSQNVQKIRENERSILERAGYFQSITVGIAPIV 410

  Fly   323 TRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQS 387
            ..::..|:...:::||..||...||.:...:|.:...:.| .|..:..::|..||:.|.:.....
 Frog   411 VVIASVLTFSVHMILGYDLTAAQAFTVVTVFNSMTFALKV-TPFSVKSLSEASVSMDRFKSLFLM 474

  Fly   388 DETNVM-------DMSVDL--------------------------------------TEDFQGSN 407
            :|.:::       ::.::|                                      :.:.:||.
 Frog   475 EEVHMVKKKPSSPNLIIELKNATLAWDTTYASTQCSPKGTPKLKKGKKGVKGKKEKCSHEIEGSQ 539

  Fly   408 ----QETVH--ADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGV 466
                ::..|  .|.||.....|:....|.|     |.||..|                   |..:
 Frog   540 AVLAEQKGHLLIDSDEHPSPDEETKELPVI-----NVKLQRA-------------------LYSI 580

  Fly   467 NLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFG 531
            :|.::.|.::||.|..||||:|||.||||::....|.|.|:||.:|.:|:.|:.:.|:|.|||||
 Frog   581 DLDIEKGKLIGICGSVGSGKTSLISAILGQMTLLEGSIAVSGSFAYVAQQAWILNATLRDNILFG 645

  Fly   532 QPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDP 596
            :..|...|..|:..|.|..|..:||..|.|.:|||||:|||||:.|||||||:|.:.|||:||||
 Frog   646 KEFDEEEYNAVLNVCCLRPDLAILPNGDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDP 710

  Fly   597 LSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLD 661
            |||:|.||..|:|...:|.:|:.:.::..|||||:|...|.::.|.:|.::..||:|.|.:...:
 Frog   711 LSALDAHVGNHIFNSAIRKHLKSKTILFITHQLQYLVDCDDVIYMKEGCITERGTHEDLIKLNGE 775

  Fly   662 FASM-----LADPERDEQSEERSRSRSGSYTHSHSDQRRNSEQSLL------SMADSCMDDLEAE 715
            :|::     |.|....||                .:.::|.:.||.      :.|.|...:...:
 Frog   776 YAAIFNNFQLGDAPHIEQ----------------MNLKKNLKNSLKKPLEKGNKAGSVKKEKTVK 824

  Fly   716 QANNQ----ERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTK-KG 775
            :...|    |.:..|.:...:|..|.::.||.|||.::|...||:.|..:..:::||||:.: .|
 Frog   825 KEEGQLMQLEEKGKGSVPWSVYGAYIQSAGGPFAFLIIMTLFVLNVGSTAFSNWWLSYWIKQGSG 889

  Fly   776 NVAYRADNNDTTRSEELE--PRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNL 838
            |... ..:|:|..|..::  |.:              :..|.|:.:..|:.:|:...|..:|...
 Frog   890 NTTV-VVHNETVVSNSMKDNPHV--------------LFYTAIYALSMVVMLLLKAVRGIVFVKG 939

  Fly   839 AMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILP----AVMMDVIQIFLAL 899
            .::||.|||:.:||.|.|:.|.||:|.|:||:||||||||.:||..||    ..:.:||.:|..|
 Frog   940 TLRASSRLHDELFRRILRSPMKFFDTTPTGRVLNRFSKDMDEVDVRLPFQAEMFVQNVILVFFCL 1004

  Fly   900 AGIVIVIAVVNPLFLI---PTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLS 961
            .    ||:.|.|.||:   |.|||..|.:.:...::   |::||:|.||:||..||:.:|:.||:
 Frog  1005 G----VISFVFPWFLVAVGPLVVLFTILHVVSRVFI---RELKRLENITQSPFLSHITSSIQGLT 1062

  Fly   962 TIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCFCVIYIAIITLSFFIFPPANG-- 1024
            ||.|:.........:....|.:.:.||:|....|.....||   ||.:::||.:..:....:|
 Frog  1063 TIHAYSKGNEFLLRYQELLDNNQAPFYLFNCAMRWLAIRLD---VISVSLITTTGLMIVLMHGNI 1124

  Fly  1025 --GDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPA---DKKPPKS 1084
              ...|||::.|:.:||:.|:.:|.::|.|...|:|||:..|....   ||||||   :|.||..
 Frog  1125 SPAYAGLAMSYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTL---ALEAPARIKNKAPPAD 1186

  Fly  1085 WPEQGKIVFDELSLRYTPDPKSEN---VLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SY 1145
            ||::|:|.|:...:||     .||   |||.:||.||||||:|||||||:||:||..||||| ..
 Frog  1187 WPQEGEIKFENAEMRY-----RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKTSLGMALFRLVEL 1246

  Fly  1146 NDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEV 1210
            :.|.:.||....|::||.|||||:|||||||||||||:|.|||||.:||::::|.:||...:||.
 Frog  1247 SGGCIKIDGVKISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFSQYSEEQIWDALERTHMKEC 1311

  Fly  1211 VADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKF 1275
            ||.||..|::::.|.|.|||||:|||:|:||.:||..:||::|||||.:|.:||.|||.|||..|
 Frog  1312 VAQLPLKLETEVLENGENFSVGERQLMCIARVLLRRCKILILDEATAAMDTETDLLIQETIREAF 1376

  Fly  1276 KECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVF 1322
            .|||:|||||||||::..|:::|:..|:.:|:.||..||:..:::.|
 Frog  1377 AECTMLTIAHRLHTVLSCDRIMVLAQGQVMEYDTPSALLSNENTRFF 1423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	468/1402 (33%)
		ABC_membrane	107..360	CDD:294371	69/264 (26%)
		ABCC_MRP_domain1	445..645	CDD:213217	85/199 (43%)
		ABC_membrane	815..1014	CDD:294371	74/205 (36%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	124/224 (55%)
abcc5	XP_012818083.1	PLN03130	101..1425	CDD:215595	470/1410 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930