DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and abcc6b.2

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	XP_003198194.2	Gene:	abcc6b.2 / 100002917	ZFINID:	ZDB-GENE-110208-2	Length:	1502	Species:	Danio rerio

Alignment Length:	1403	Identity:	458/1403 - (32%)
Similarity:	727/1403 - (51%)	Gaps:	194/1403 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTKGKPN 77
            |.|..:|:|...||:.....:||.:..|..:||:...:|..||.:...|...|..:..|.:.|.:
Zfish   207 PVEDASFLSKLLFWWYGRLVVKGYRSPLKAEDLWSLREEDTSEKIICDLEKEWAKQWAKLQQKKS 271

  Fly    78 --------------------------------LLRALLRVFGWYFALLGLVLFLLELGLRTLQPI 110
                                            |.|.|.::|..|| |.|.:..:::..|....|.
Zfish   272 SLNEAQTLGFKLSSCVKQLFRKLFKEQCTGFVLFRTLAKIFSPYF-LTGTLFLVIQDALMFSIPQ 335

  Fly   111 FLLKLIAYYTHGSESIESAYYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALR 175
            .|..|:.|.......:...|.:|..:.|.|.|..:..|.||...:.||::::..:..::|||:|.
Zfish   336 VLSLLLGYVRDEDAPLWKGYLFAFSLFLLSCLQSLFNHQYMYTCLTVGMRVKTAVMGLVYRKSLV 400

  Fly   176 LSKSALGDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFML 240
            ::.:|....|.|.:|||:|.|..:|....::.:.||:.|:|.....:.:::.:|.:.:.|:..::
Zfish   401 INSAARKTCTVGEIVNLVSADTQKLVDFVMYFNALWLAPIEIALCLFFLWQHLGPSTLAGITTVI 465

  Fly   241 LFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAI 305
            |..||..::.|..|.|:.......|||:::||||:|||:::|.||||..|...|...|:||:||:
Zfish   466 LIFPLNGFIAKMRSKLQEVQMKHKDERIKLMNEILSGIKILKFYAWEKAFRERVLGYREKELNAL 530

  Fly   306 RHVSYIRGILLSFIIFLTRVSIFLS---LVGYVLLGTF--------LTPEVAFLITAYYNILRTT 359
            :.         |.|::...::.|.|   |:.:.:.|.:        |..:..|:..|..|||:..
Zfish   531 KK---------SQILYSVSIASFNSSTLLIAFAMFGVYVLIDDKHVLDAQKIFVSMALINILKAP 586

  Fly   360 MTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAED 424
            ::. .|..:|...:.:||:||:..::..||..:                           |..:.
Zfish   587 LSQ-LPIAMSTTMQVVVSLKRLGTFLDQDELKL---------------------------DSVQR 623

  Fly   425 KLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSL 489
            ....|.|.:|..|          :|..: |..:|.. .|..:|::||.|:::.:||..|||||||
Zfish   624 VPYNPNIESVVIN----------NGTFS-WSKDSTP-CLRRINVKVQRGSLVAVVGHVGSGKSSL 676

  Fly   490 IQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFEL 554
            :.|:|||:..:||.|.:.||:.|..|:.|:.:.|::.|||||.......|.||::.|||..|.|:
Zfish   677 LSAMLGEMEKKSGHITITGSVGYVPQQAWIQNATLKDNILFGCEKKDSLYQKVLEACALLPDLEI 741

  Fly   555 LPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCM--RGYL 617
            ||.:|.|.:||:|.:||||||.|:||||||||.:.||||||||||||.||.:|:||:.:  .|.|
Zfish   742 LPARDATEIGEKGLNLSGGQKQRVSLARAVYRNSDIYLLDDPLSAVDAHVGQHIFEKVIGPNGSL 806

  Fly   618 RERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLDFASMLA--DPERDEQSEERSR 680
            :.:..:|.||.|.||..||.|::|..|.:..:|:|..|......||.:.|  ..||.|.:..:..
Zfish   807 KNKTRVLVTHGLSFLPQADLILVMADGEIKEMGSYAELLSRKNAFAELKAFSVSERKESATLKGT 871

  Fly   681 SRSGSYTHSHSDQRRNSEQSLLSMADSCMDDLEAEQAN--------------NQERQE------- 724
            .:|.|:               ||:.|...|.:..:..:              ||:|.|
Zfish   872 RKSVSF---------------LSIKDFSTDLIRGDLGSASIQTMEAISDPKLNQDRDEVGRLTQA 921

  Fly   725 ----AGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLG-DYFLSYWVTKKGNVAYRADN- 783
                .|::.|.:|.:||:..|  .||.:.:.|....|.:|||. :|:||.|          ||:
Zfish   922 DKAHTGRVKLEMYVEYFRTIG--LAFIIPIIFLYAFQQVASLAYNYWLSLW----------ADDP 974

  Fly   784 --NDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRL 846
              |.|..:.:|  :|..: ..:|.:....:..|         |:.:::.        .:.||.:|
Zfish   975 VINGTQVNTDL--KLGVY-GALGFAQGIAIFGT---------TVAISLG--------GIIASRQL 1019

  Fly   847 HNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNP 911
            |..:...:..:.|.||.:.|||.:||||||::..:|.::|..:..::.....|..:.|::.:..|
Zfish  1020 HLDLLNNVLHSPMSFFESTPSGNLLNRFSKEIDAIDCMIPHGLKIMLGYVFKLLEVCIIVLMATP 1084

  Fly   912 LFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEF 976
            ...:..:.|.:::..:::||:.||..::|:|:::|||:|:|...::.|.|.|||||.|.....:.
Zfish  1085 FAGVIILPLTLLYAFIQSFYVATSCQLRRLESVSRSPIYTHFNETVQGASVIRAFGEQPRFILQA 1149

  Fly   977 DNYQDMHSSAFYMFISTSRAFGYWLDCFC-----VIYIAIITLSFFIFPPANGGDVGLAITQAMG 1036
            :...|::.::::.....||    ||....     ::.:|...||.......:.|.||||::.::.
Zfish  1150 NCRVDLNQTSYFPRFVASR----WLAVNLEFLGNLLVLAAAILSVMGRATLSPGTVGLAVSHSLQ 1210

  Fly  1037 MTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAP---ADKKPPKSWPEQGKIVFDELSL 1098
            :||::.|.:|...::||.:.:||||.||    .|.|.|||   .|...|..||..|.|.|....|
Zfish  1211 VTGILSWIVRSWTDVENNIVSVERVKEY----AETAKEAPWTFEDSPLPSDWPRSGSIGFQAYGL 1271

  Fly  1099 RYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVLIDKRDTSEMGL 1162
            :|...  .:..||.:|..:..:||||||||||||||||...:|| |....|.:.||..:.:|:||
Zfish  1272 QYRKG--LDWALKEISLSVNEREKVGIVGRTGAGKSSLALGIFRILEAAKGKIFIDGINIAEIGL 1334

  Fly  1163 HDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGT 1227
            |:|||:|:||||:||||||::|.||||||.|:|:::|||||...||..|:|||..|..:.:|||.
Zfish  1335 HELRSRITIIPQDPVLFSGSLRINLDPFDRYTDEEVWRSLELAHLKTFVSDLPDKLNHECSEGGE 1399

  Fly  1228 NFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMD 1292
            |.|:|||||:|||||:||:.:|||:|||||.||.:||.|||:|||.:|::||||||||||:||||
Zfish  1400 NLSLGQRQLICLARALLRKTKILVLDEATAAVDLKTDNLIQSTIRTQFEDCTVLTIAHRLNTIMD 1464

  Fly  1293 SDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTG 1330
            ..:|:|||.|...|..:|..|  ::....|:.|.::.|
Zfish  1465 YTRVIVMDRGNITEIDSPSNL--ISQHGQFYRMCREAG 1500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	455/1386 (33%)
		ABC_membrane	107..360	CDD:294371	73/263 (28%)
		ABCC_MRP_domain1	445..645	CDD:213217	94/201 (47%)
		ABC_membrane	815..1014	CDD:294371	48/203 (24%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	125/221 (57%)
abcc6b.2	XP_003198194.2	MRP_assoc_pro	5..1501	CDD:188098	458/1403 (33%)
		ABC_membrane	320..587	CDD:294371	74/275 (27%)
		ABCC_MRP_domain1	633..834	CDD:213217	96/212 (45%)
		ABC_membrane	950..1215	CDD:279056	74/298 (25%)
		ABCC_MRP_domain2	1262..1482	CDD:213211	125/221 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586062
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.760