DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and abcc1

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	XP_001341895.3	Gene:	abcc1 / 100002010	ZFINID:	ZDB-GENE-050517-15	Length:	1518	Species:	Danio rerio

Alignment Length:	1398	Identity:	487/1398 - (34%)
Similarity:	751/1398 - (53%)	Gaps:	170/1398 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTK---- 73
            |....:|:|...||:.....:||.||.|:.|||:....|.|||.:..:|...|:.|..|.|
Zfish   209 PESGASFLSKITFWWITGLMVKGYKRPLEEKDLWSLNNEDKSERVVPQLVRRWDQECVKVKRPVD 273

  Fly    74 ----------------------------------GKPNLLRALLRVFGWYFALLGLVLFLLELGL 104
                                              |:|:|..||.|.||.||.:..|...:.:: |
Zfish   274 KTLYSPKRSTRGEKKDGQPVEESEILLAKALQKTGEPSLFFALCRTFGPYFLVSSLYKIIHDV-L 337

  Fly   105 RTLQPIFLLKLIAYYTHGSESIESAYYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMI 169
            ..:.|..|..||.:....|......|:|.|.:.:|:.|..:|:..|.......|:::|..:...:
Zfish   338 MFVGPEILRLLILFVNDSSAPTWHGYFYTALLFVCTCLQTLILQKYFHVCFVTGMRLRTAIVGAV 402

  Fly   170 YRKALRLSKSALGDTTAGHVVNLMSNDVGR-LDLATIFVHYLWVGPLETLFITYLMYREIGIAAV 233
            |||||.::.:|...:|.|.:|||||.|..| :||.| :::.:|..||:.:...|.:::.:|.:.:
Zfish   403 YRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLIT-YINMIWSAPLQVILALYFLWQNLGASVL 466

  Fly   234 FGVAFMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFAR 298
            .|||.|:|.:||.|.:..:|...::......|.|:::|||:::||:|:|:|||||.|:..|:..|
Zfish   467 AGVAVMVLMVPLNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKGKVSAIR 531

  Fly   299 KKEINAIRHVSYIRGILLSF----IIFLTRVSIFLSLVGYVLL--GTFLTPEVAFLITAYYNILR 357
            :.|:..::.::|: |.:.:|    ..||..:|.|   ..|||:  ...|..:.||:..|.:||||
Zfish   532 ESELRVLKKMAYL-GAISTFTWVCAPFLVALSTF---AVYVLVDENNILDAQKAFVSLALFNILR 592

  Fly   358 TTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEA 422
            ..:.: .|..||.|.:..||::|::.::..:|.:                      |.:.||
Zfish   593 FPLNM-LPMVISSMVQASVSMQRLRVFLSHEELD----------------------DDNVER--- 631

  Fly   423 EDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKS 487
                  |.|:...::.::::...|       |..:.|. :|..:|:.:..|.::.:||..|||||
Zfish   632 ------PAISGTPDSIRIADGAFS-------WSKDDPP-TLKRINVSIPEGALVAVVGHVGSGKS 682

  Fly   488 SLIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDF 552
            ||:.|:|||:..:.|.:.:.||::|..|:.|:.:.|::.|||||:......|.|||:.|||..|.
Zfish   683 SLLSALLGEMHKQEGSVSIKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACALLPDL 747

  Fly   553 ELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCM--RG 615
            |:||..|.|.:||:|.:||||||.|:|:|||||...|:|||||||||||.||.:|:||:.:  :|
Zfish   748 EILPGGDTTEIGEKGVNLSGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVIGPQG 812

  Fly   616 YLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLDFASML-----ADPERDEQS 675
            .|:.|..:|.||.|.||..||.|::|..|.::.:|:|..|......||..|     .:.|..|:|
Zfish   813 LLQGRTRVLVTHGLSFLPQADLILVMVDGEITEMGSYTELLGRQGAFAEFLRTYTNTEQEEGEES 877

  Fly   676 EERSRSRSGSYTHSHSDQRRNSEQSL-------LSMADSCMDD--------LEAEQANNQERQEA 725
            ...:..|.|......:...|.|:.||       .:......||        .||.:....::...
Zfish   878 LGDAVPRKGLENGGPAALLRQSQISLNATGAGKTTQKTEANDDAAATKTKSAEASRLTEADKANT 942

  Fly   726 GQIGLRLYSKYFKAGG---GFFAFFVMMGFCVLSQGLASLG-DYFLSYWVTKKGNVAYRADN--- 783
            |::.|.::.:|.||.|   ..|:.|:.  ||   ..|:||| :|:||.|          .|:
Zfish   943 GRVKLSVFWEYMKAIGLPLSIFSIFLF--FC---HHLSSLGSNYWLSLW----------TDDPVV 992

  Fly   784 NDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTV-ITVLTILVTVARSFLFFNLAMKASIRLH 847
            |:|....|:  ||..: ..:|:|   :.:..:.::| ::|..||               ||..||
Zfish   993 NNTQPKREM--RLGVY-GALGIS---QGIAVFCYSVSVSVGGIL---------------ASRYLH 1036

  Fly   848 NSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPL 912
            .:|...:.|:.|.||...|||.::|||:|:...:|.::|:::...:.....:.|...||.:..||
Zfish  1037 QTMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPL 1101

  Fly   913 FLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFD 977
            ..|....||::::.::.||:.:||.:||:|:::|||||:|...:|.|.|.|||||.|:....|.|
Zfish  1102 VAIIIPPLGLLYFFVQRFYVASSRQMKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIKESD 1166

  Fly   978 NYQDMHSSAFYMFISTSRAFGYWLDCF--CVIYIAIITLSFFIFPPAN--GGDVGLAITQAMGMT 1038
            ...|.:..|::..|..:|.....|:..  |::..|.:   |.:....|  .|.:||:|:.|:.:|
Zfish  1167 GRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAAL---FAVMARNNLSPGIMGLSISYALQVT 1228

  Fly  1039 GMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPD 1103
            ..:.|.:|.|:|||..:.|||||.||.|.|.|...:......|| .||..|.|...:..|||..|
Zfish  1229 ASLNWLVRMSSELETNIVAVERVKEYGDTEKEAEWKLENSNLPP-GWPTAGHIEIHKFGLRYRED 1292

  Fly  1104 PKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVLIDKRDTSEMGLHDLRS 1167
              .|..:..:|..|...||||||||||||||||...||| :...:|.:.||..:.:::|||:|||
Zfish  1293 --LELAICDISVNIAGGEKVGIVGRTGAGKSSLTLGLFRIIEAAEGEIRIDGVNIADLGLHELRS 1355

  Fly  1168 KISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVG 1232
            :|:||||:||||||::|.||||||.|:|:::|||||...||..|:.||..|..:.:|||.|.|:|
Zfish  1356 RITIIPQDPVLFSGSLRMNLDPFDGYTDEEVWRSLELAHLKTFVSGLPDKLNHECSEGGENLSLG 1420

  Fly  1233 QRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVL 1297
            ||||||||||:||:.:|||:|||||.||.:||.|||:|||.:|::||||||||||:||||..:||
Zfish  1421 QRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVL 1485

  Fly  1298 VMDAGRAVEFGTPYELLTLADSKVFHGMVKQTG 1330
            |:|.|:..||.:|..|  :|...:|:.|.|.:|
Zfish  1486 VLDKGQMAEFDSPSNL--IAKKGIFYKMAKDSG 1516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	482/1381 (35%)
		ABC_membrane	107..360	CDD:294371	82/259 (32%)
		ABCC_MRP_domain1	445..645	CDD:213217	90/201 (45%)
		ABC_membrane	815..1014	CDD:294371	61/201 (30%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	126/221 (57%)
abcc1	XP_001341895.3	MRP_assoc_pro	7..1517	CDD:188098	487/1398 (35%)
		ABC_membrane	331..595	CDD:279056	83/269 (31%)
		ABCC_MRP_domain1	641..842	CDD:213217	90/208 (43%)
		ABC_membrane	966..1231	CDD:279056	88/303 (29%)
		ABCC_MRP_domain2	1278..1498	CDD:213211	126/221 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585969
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.760