DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and ABCC3

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_003777.2	Gene:	ABCC3 / 8714	HGNCID:	54	Length:	1527	Species:	Homo sapiens

Alignment Length:	1620	Identity:	485/1620 - (29%)
Similarity:	757/1620 - (46%)	Gaps:	290/1620 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ETNDLLPCFQEILLQ-LPVYTLFAAISAYNFGNQSRHVVRNGLQLRMLS-IRTFLAMVLALLPVA 90
            |..||.||||..||. :|...|:.|:..|..  ..||..|..:.|..|| ::..|.::|..:..|
Human    24 ENPDLTPCFQNSLLAWVPCIYLWVALPCYLL--YLRHHCRGYIILSHLSKLKMVLGVLLWCVSWA 86

  Fly    91 KVF-AFH-----------------QQGVELFAADLLVVSAECIMWVVHSGFLLTARQYGELSHRG 137
            .:| :||                 ..||.:..|.|| :..|.:..|..||.|:
Human    87 DLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLL-IQYERLQGVQSSGVLI------------ 138

  Fly   138 SLLINVVWLTVVVLDAVWLRTSRHFSWWPWSLATLVCDLLFGVTLIPKGSAVYSSLPRSGVSARE 202
                 :.|...|                       ||      .::|.         ||.:...:
Human   139 -----IFWFLCV-----------------------VC------AIVPF---------RSKILLAK 160

  Fly   203 DEGLLSQ--RYT--YFQFDLNESHL--------------------GHAQDEANLGSRFLFHWVQP 243
            .||.:|.  |:|  |..|.|..|.|                    .:.:..|...||..|.|...
Human   161 AEGEISDPFRFTTFYIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTK 225

  Fly   244 LILKGVAGKLRKIEDLFDLPD----------ALNITRLSEK---LHLALS--------------- 280
            :.:.|....|.: :||:.|.:          .|...|..||   .|.|.:
Human   226 MAIYGYRHPLEE-KDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLG 289

  Fly   281 -----QSQSLWRALHRCFGVEFYLIGILRLIADLSGFAGPLLLGGLLR--QDHADPNQVYYYALG 338
                 :..|..:||...||..|.:....:||.||..|..|.||..|:|  .:...|:...:...|
Human   290 ARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAG 354

  Fly   339 L-FGSTLLSAVCATHFDWRMAMVSMKMRVGVVNSIYRKALE-ARGLKESKP--DLLNLMSTDTDR 399
            | |..:::.::...|:...:.:..:|.|.|::..||||||. ...:|.:..  :::||||.|..|
Human   355 LMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQR 419

  Fly   400 IVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLMTAK 464
            .::.....:..||.|.::...:|.|:..||.:.||||.|..||||:|..:|.::..|....|..|
Human   420 FMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLK 484

  Fly   465 DARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATTPVLMCLL 529
            |:|:...:|.:.|.|.:|:.|||..|:.::.|:||.||:.|....||.....:.|..:|.|:.|:
Human   485 DSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLI 549

  Fly   530 TFGVSVLM--GNPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDVPNLDYS 592
            |..|.|.:  .|.|.|...:.||:|..:|..|||..|.:::.|.:|.||:||:||.:....||..
Human   550 TLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQ 614

  Fly   593 SYYNPIMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSDEQTSPTPFRMKDINVDIKAGQLVC 657
            |    :.|.:...|            ..:.:...:|....|     .|..:..:::.:..|.||.
Human   615 S----VERKTISPG------------YAITIHSGTFTWAQD-----LPPTLHSLDIQVPKGALVA 658

  Fly   658 IEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIVWGAQFDEQWY 722
            :.||||.||||.:||::..::..:|:|   .:.....||||..|:|..|:::|:::|...:.:.|
Human   659 VVGPVGCGKSSLVSALLGEMEKLEGKV---HMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY 720

  Fly   723 KTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLDAHV 786
            :..|.||||..||::| |||...:||.|..||||||.||:||||||.|..::||||.||::|:||
Human   721 QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHV 785

  Fly   787 ARHIIKHCI--LRLLKHKTRIVVTRNIQLFFHANQILQVKDGQLL-------------------- 829
            |:||..|.|  ..:|..|||::||..|......:.|:.:.|||:.
Human   786 AKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLC 850

  Fly   830 -------------------------------------------PSEYMTQS---IELS-LDEDAD 847
                                                       |..|:.|.   .:|| |..|.:
Human   851 NYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGE 915

  Fly   848 DEQEPTVRR-----RSVELSNQYDKKSLDSLLLEELREYGHLSGNVFTCYWKAVTSPLAFTVLLS 907
            .:..|..||     ..|:::   :.|:..:|..||....|.:..:||..|.|||    .....|:
Human   916 GQGRPVPRRHLGPSEKVQVT---EAKADGALTQEEKAAIGTVELSVFWDYAKAV----GLCTTLA 973

  Fly   908 VVLMQLTRNL----SDAWLAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGHTTKFYLSIFTA 968
            :.|:.:.::.    ::.||:.|..:...|..:|:|||                     .|.::.|
Human   974 ICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSL---------------------RLGVYAA 1017

  Fly   969 IAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDS 1033
            :.:....:.:..|...|..||:||..:|:.||...:.:..:|||.|..|||||.||.|...||:.
Human  1018 LGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEV 1082

  Fly  1034 LPFILNILLAQLAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSPL 1098
            |..::.:||......:..|.|.:.:.|...:||:|:..:|..:|:.|...||.:|||.|.:.||:
Human  1083 LAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPI 1147

  Fly  1099 YTHFTETLQGLTTIRSMRASPRFQRDFQV----KLEESIKAQLTQSAAQQWLALRLQLLGTLLVG 1159
            |:||:||:.|.:.||:...|    |||::    |::.:.::......:.:||::.::.:|..:|.
Human  1148 YSHFSETVTGASVIRAYNRS----RDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVL 1208

  Fly  1160 GAGLLAAITASHTTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQYLQLEEEQN- 1223
            .|.|.|.|..| :.|||||||.:||:|.:|..|..::..:::.|..:|||||:.:|.:.|.|..
Human  1209 FAALFAVIGRS-SLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPW 1272

  Fly  1224 -ASGSAEPPFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAAL 1287
             ..|| .||.|||.:|.:.||...:.||..|...||.::......|::||||||||||:|:...|
Human  1273 VVEGS-RPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCL 1336

  Fly  1288 LRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKN 1352
            .|:.....||||:|.:|:..:.|..||.::.:|.|:|.||.||:|.||||...:.:.:||.|::.
Human  1337 FRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALEL 1401

  Fly  1353 SAAATLLVQQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQ 1417
            |...|.:..|..|||.:....|.|||.|||||:|||||||:.::::.:||.|:.:|.|:|..||.
Human  1402 SHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQA 1466

  Fly  1418 ALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFYGMLLAQD 1477
            .:|..|.:||:|.|||||..:....|::|||.|.:.|..:|.:|.: :..|||||  |:|
Human  1467 TIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIA-ARGIFYGM--ARD 1523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	481/1613 (30%)
		ABC_membrane	328..560	CDD:294371	74/237 (31%)
		ABCC_MRP_domain1	621..827	CDD:213217	80/208 (38%)
		ABC_membrane	948..1192	CDD:279056	78/247 (32%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	92/219 (42%)
ABCC3	NP_003777.2	SunT	7..1526	CDD:331423	485/1620 (30%)
ABCC3	NP_003777.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..932		5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720