DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and ABCC11

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_001357425.1	Gene:	ABCC11 / 85320	HGNCID:	14639	Length:	1384	Species:	Homo sapiens

Alignment Length:	1461	Identity:	403/1461 - (27%)
Similarity:	658/1461 - (45%)	Gaps:	263/1461 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 IPKGSAVYSSLPRSGVSARED--EGLLSQRYT-----YFQFDLNESHLGHAQ------------- 227
            :|..|   ..|...|:...:|  .||:.:.||     :.|.:.|....|.|.
Human     9 VPNSS---GGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPPWGKYDAALRT 70

  Fly   228 ----------------DEANLGSRFLFHWVQPLILKGVAGKLRKIEDLFDLPDALNITRLSEKLH 276
                            |.|.|.|.....|:.||:::.:..:|          |...|..||  :|
Human    71 MIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRL----------DENTIPPLS--VH 123

  Fly   277 LALSQSQSLWRALHRCFGVEFYLIGI--------------LRLIAD--------LSGFAGPLLLG 319
            .|   |....:.|||.:..|....||              .|||.|        ::...||:|:.
Human   124 DA---SDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILII 185

  Fly   320 GLLRQDHADPNQVYYYALGLFGSTLLSAVCATHFDWRMAMV-----SMKMRVGVVNSIYRKALEA 379
            ..:.:...:......:.:||..:..||. |.....:..:.:     :::.|..|.:..:.|.::.
Human   186 PKILEYSEEQLGNVVHGVGLCFALFLSE-CVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQF 249

  Fly   380 RGLKESKPDLLNLMSTDTDRIVNSCISF------HFFWSI---PFKLFTTLYLLYLQLGAAFLAG 435
            :       .::::.|       ...|||      :.|..:   |..|.|...|:...:.:.|:.|
Human   250 K-------SVIHITS-------GEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300

  Fly   436 -VIFAALLIPINRWLAKRIGIFSSGLMT--------AKDARLSATTETMQGAKQIKINAWEDIFI 491
             ..|.|:|..:   |...:.:|.:.:..        ..|.|:..|:|.:...|.||:..||..|.
Human   301 YTAFIAILCYL---LVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFA 362

  Fly   492 TKIRGLRQEELRFLSKRKYLDAMCVYFWATTPVLMCLL---TFGVSVLMGN----PLIASTTYTS 549
            ..|..||::|.:.|.|       |....:.|.:.:.::   ...|.||:..    .|.||..::.
Human   363 KIIEDLRRKERKLLEK-------CGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420

  Fly   550 VALLYMLIGPLNAF--PWVLNGLIEAWVSIKR-------------VQQLMDVPN---------LD 590
            :|.|.:|  .|:.|  |..:.||..:..::.|             ||.|.| |:         |.
Human   421 LASLNLL--RLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQD-PSKALVFEEATLS 482

  Fly   591 YSSYYNPIMRG------SGGSGAGDDAPLDA--PKASVLQMKCASFCHDSDEQTSPTPFRMKDIN 647
            :......|:.|      :|.:..|...|.||  |:               :|..|..| .:..||
Human   483 WQQTCPGIVNGALELERNGHASEGMTRPRDALGPE---------------EEGNSLGP-ELHKIN 531

  Fly   648 VDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIV 712
            :.:..|.::.:.|..|.||||.||||:..:...:|.|.||   ....||||..|:..|.||:||:
Human   532 LVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQ---GSLAYVPQQAWIVSGNIRENIL 593

  Fly   713 WGAQFDEQWYKTVLHACALEEDLQILG-GDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLD 776
            .|..:|:..|..|||.|:|..||::|. ||:..:||.|..|||||:.|::||||||.|:::||||
Human   594 MGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLD 658

  Fly   777 DVLSSLDAHVARHIIKHCILRLLKHKTRIVVTRNIQLFFHANQILQVKDGQLLP----SEYMTQS 837
            |.||::||||.:||.:.||.:.|:.||.::||..:|......||:.:::|::..    ||.|.:.
Human   659 DPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKK 723

  Fly   838 IELS--------------LDEDADDEQEPTVRRRSVELSNQYDKKSLD---------SLLLEELR 879
            .:.:              |.:.|...::|.|..:::..|.:   :||:         .|..||..
Human   724 GKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLE---ESLNGNAGNVPEHQLTQEEEM 785

  Fly   880 EYGHLSGNVFTCYWKA----VTSPLAFTVLLSVVLMQLTRNLSDAWLAYWVTE---TTLDPHKND 937
            |.|.||..|:..|.:|    :.|.:.|..::.:|.:.:   .|..||:||:.:   |......|.
Human   786 EEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTI---FSFWWLSYWLEQGSGTNSSRESNG 847

  Fly   938 TSLDHILMRPTVGNETESGHTTKFYLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKK 1002
            |..|       :||..::...: ||..::...|:....|.:..:.:|.....||:..:|.||..|
Human   848 TMAD-------LGNIADNPQLS-FYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNK 904

  Fly  1003 VMFAKFNFFDITSVGRILNRFSSDTNTVDDSLP-FILNILLAQLAGLVGALCVSLYAMPW---LG 1063
            |.....:|||...:||:||.|:.|...:|..|| |....|:..|..:...|.||:.: |:   :|
Human   905 VFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLS-PYILLMG 968

  Fly  1064 LVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVK 1128
            .:|:.:..||..:   ::.|....|||.:.:.|||::|...:||||::|.....:..|...|:..
Human   969 AIIMVICFIYYMM---FKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRL 1030

  Fly  1129 LEESIKAQLTQSAAQQWLALRLQLLGTLLVGGAGLLAAITASHTTNPGLVGLCISYALSITGQLG 1193
            .:......|...::.:|:||||:::..|:.....|..|...|.|.....|     .|::|..||.
Human  1031 TDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKV-----MAVNIVLQLA 1090

  Fly  1194 DLLHAVA----ETEQELVAVERIDQYLQL---EEEQNASGSAEPPFGWPTQGVLSFREVQLSYRE 1251
            ....|.|    |||.:..|||||.||:::   |...:..|::.|. |||..|.:.|::..:.||:
Human  1091 SSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQ-GWPQHGEIIFQDYHMKYRD 1154

  Fly  1252 HLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRER 1316
            :....|.||.......|.:|||||||:||:|:..||.|:.....|.|.:|.|::.::.|..||.:
Human  1155 NTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSK 1219

  Fly  1317 IGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQLGGLDGKVET----CGNNL 1377
            :.||.|:|.|..||:|.||||.....|.:||.|::.    |.|.:.:.....|:.|    .|.|.
Human  1220 LSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALER----TFLTKAISKFPKKLHTDVVENGGNF 1280

  Fly  1378 SAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMD 1442
            |.|:|||||:|||:|:|:|::.|||.|:::|.|:|..||:.:|.||:.||:|.||||:..:...|
Human  1281 SVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCD 1345

  Fly  1443 RIIVLDDGRICEEGNPQSLASDSSTIFYGML 1473
            .|:|:.:|::.|...|:.|.....::|..::
Human  1346 HILVMGNGKVVEFDRPEVLRKKPGSLFAALM 1376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	403/1458 (28%)
		ABC_membrane	328..560	CDD:294371	51/261 (20%)
		ABCC_MRP_domain1	621..827	CDD:213217	82/206 (40%)
		ABC_membrane	948..1192	CDD:279056	66/247 (27%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	87/223 (39%)
ABCC11	NP_001357425.1	PLN03130	85..1373	CDD:215595	389/1377 (28%)
ABCC11	NP_001357425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..523		6/33 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720