Protein Alignment CG7806 and ABCC11

DIOPT Version :10

• Sequence 1: NP_609207.1
• Gene: CG7806 / 34140
• FlyBaseID: FBgn0032018
• Length: 1487
• Species: Drosophila melanogaster
• Sequence 2: NP_001357425.1
• Gene: ABCC11 / 85320
• HGNCID: 14639
• Length: 1384
• Species: Homo sapiens
• Alignment Length: 1461
• Identity: 403/1461 - (27%)
• Similarity: 658/1461 - (45%)
• Gaps: 263/1461 - (18%)

  Fly   183 IPKGSAVYSSLPRSGVSARED--EGLLSQRYT-----YFQFDLNESHLGHAQ------------- 227
            :|..|   ..|...|:...:|  .||:.:.||     :.|.:.|....|.|.
Human     9 VPNSS---GGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPPWGKYDAALRT 70

  Fly   228 ----------------DEANLGSRFLFHWVQPLILKGVAGKLRKIEDLFDLPDALNITRLSEKLH 276
                            |.|.|.|.....|:.||:::.:..:|          |...|..||  :|
Human    71 MIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRL----------DENTIPPLS--VH 123

  Fly   277 LALSQSQSLWRALHRCFGVEFYLIGI--------------LRLIAD--------LSGFAGPLLLG 319
            .|   |....:.|||.:..|....||              .|||.|        ::...||:|:.
Human   124 DA---SDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILII 185

  Fly   320 GLLRQDHADPNQVYYYALGLFGSTLLSAVCATHFDWRMAMV-----SMKMRVGVVNSIYRKALEA 379
            ..:.:...:......:.:||..:..||. |.....:..:.:     :::.|..|.:..:.|.::.
Human   186 PKILEYSEEQLGNVVHGVGLCFALFLSE-CVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQF 249

  Fly   380 RGLKESKPDLLNLMSTDTDRIVNSCISF------HFFWSI---PFKLFTTLYLLYLQLGAAFLAG 435
            :       .::::.|       ...|||      :.|..:   |..|.|...|:...:.:.|:.|
Human   250 K-------SVIHITS-------GEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300

  Fly   436 -VIFAALLIPINRWLAKRIGIFSSGLMT--------AKDARLSATTETMQGAKQIKINAWEDIFI 491
             ..|.|:|..:   |...:.:|.:.:..        ..|.|:..|:|.:...|.||:..||..|.
Human   301 YTAFIAILCYL---LVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFA 362

  Fly   492 TKIRGLRQEELRFLSKRKYLDAMCVYFWATTPVLMCLL---TFGVSVLMGN----PLIASTTYTS 549
            ..|..||::|.:.|.|       |....:.|.:.:.::   ...|.||:..    .|.||..::.
Human   363 KIIEDLRRKERKLLEK-------CGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420

  Fly   550 VALLYMLIGPLNAF--PWVLNGLIEAWVSIKR-------------VQQLMDVPN---------LD 590
            :|.|.:|  .|:.|  |..:.||..:..::.|             ||.|.| |:         |.
Human   421 LASLNLL--RLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQD-PSKALVFEEATLS 482

  Fly   591 YSSYYNPIMRG------SGGSGAGDDAPLDA--PKASVLQMKCASFCHDSDEQTSPTPFRMKDIN 647
            :......|:.|      :|.:..|...|.||  |:               :|..|..| .:..||
Human   483 WQQTCPGIVNGALELERNGHASEGMTRPRDALGPE---------------EEGNSLGP-ELHKIN 531

  Fly   648 VDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIV 712
            :.:..|.::.:.|..|.||||.||||:..:...:|.|.||   ....||||..|:..|.||:||:
Human   532 LVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQ---GSLAYVPQQAWIVSGNIRENIL 593

  Fly   713 WGAQFDEQWYKTVLHACALEEDLQILG-GDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLD 776
            .|..:|:..|..|||.|:|..||::|. ||:..:||.|..|||||:.|::||||||.|:::||||
Human   594 MGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLD 658

  Fly   777 DVLSSLDAHVARHIIKHCILRLLKHKTRIVVTRNIQLFFHANQILQVKDGQLLP----SEYMTQS 837
            |.||::||||.:||.:.||.:.|:.||.::||..:|......||:.:::|::..    ||.|.:.
Human   659 DPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKK 723

  Fly   838 IELS--------------LDEDADDEQEPTVRRRSVELSNQYDKKSLD---------SLLLEELR 879
            .:.:              |.:.|...::|.|..:::..|.:   :||:         .|..||..
Human   724 GKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLE---ESLNGNAGNVPEHQLTQEEEM 785

  Fly   880 EYGHLSGNVFTCYWKA----VTSPLAFTVLLSVVLMQLTRNLSDAWLAYWVTE---TTLDPHKND 937
            |.|.||..|:..|.:|    :.|.:.|..::.:|.:.:   .|..||:||:.:   |......|.
Human   786 EEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTI---FSFWWLSYWLEQGSGTNSSRESNG 847

  Fly   938 TSLDHILMRPTVGNETESGHTTKFYLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKK 1002
            |..|       :||..::...: ||..::...|:....|.:..:.:|.....||:..:|.||..|
Human   848 TMAD-------LGNIADNPQLS-FYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNK 904

  Fly  1003 VMFAKFNFFDITSVGRILNRFSSDTNTVDDSLP-FILNILLAQLAGLVGALCVSLYAMPW---LG 1063
            |.....:|||...:||:||.|:.|...:|..|| |....|:..|..:...|.||:.: |:   :|
Human   905 VFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLS-PYILLMG 968

  Fly  1064 LVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVK 1128
            .:|:.:..||..:   ::.|....|||.:.:.|||::|...:||||::|.....:..|...|:..
Human   969 AIIMVICFIYYMM---FKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRL 1030

  Fly  1129 LEESIKAQLTQSAAQQWLALRLQLLGTLLVGGAGLLAAITASHTTNPGLVGLCISYALSITGQLG 1193
            .:......|...::.:|:||||:::..|:.....|..|...|.|.....|     .|::|..||.
Human  1031 TDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKV-----MAVNIVLQLA 1090

  Fly  1194 DLLHAVA----ETEQELVAVERIDQYLQL---EEEQNASGSAEPPFGWPTQGVLSFREVQLSYRE 1251
            ....|.|    |||.:..|||||.||:::   |...:..|::.|. |||..|.:.|::..:.||:
Human  1091 SSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQ-GWPQHGEIIFQDYHMKYRD 1154

  Fly  1252 HLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRER 1316
            :....|.||.......|.:|||||||:||:|:..||.|:.....|.|.:|.|::.::.|..||.:
Human  1155 NTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSK 1219

  Fly  1317 IGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQLGGLDGKVET----CGNNL 1377
            :.||.|:|.|..||:|.||||.....|.:||.|::.    |.|.:.:.....|:.|    .|.|.
Human  1220 LSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALER----TFLTKAISKFPKKLHTDVVENGGNF 1280

  Fly  1378 SAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMD 1442
            |.|:|||||:|||:|:|:|::.|||.|:::|.|:|..||:.:|.||:.||:|.||||:..:...|
Human  1281 SVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCD 1345

  Fly  1443 RIIVLDDGRICEEGNPQSLASDSSTIFYGML 1473
            .|:|:.:|::.|...|:.|.....::|..::
Human  1346 HILVMGNGKVVEFDRPEVLRKKPGSLFAALM 1376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	403/1458 (28%)
ABCC11	NP_001357425.1	PLN03130	85..1373	CDD:215595	389/1377 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	504..523		6/33 (18%)