DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and BPT1

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_013086.1	Gene:	BPT1 / 850645	SGDID:	S000003938	Length:	1559	Species:	Saccharomyces cerevisiae

Alignment Length:	1640	Identity:	451/1640 - (27%)
Similarity:	761/1640 - (46%)	Gaps:	283/1640 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CPTGLKPFANE-TNDLLPCFQEILLQLPVYTLFAAISAYNFGNQSRHVVRNGLQLRMLSIRTFLA 81
            ||.|.:|:.:. ||.|.|||..::..... ..|..|.:|......::   |.:..|..:..|
Yeast    10 CPYGYRPYPDSGTNALNPCFISVISAWQA-VFFLLIGSYQLWKLYKN---NKVPPRFKNFPT--- 67

  Fly    82 MVLALLPVAKVFAFHQQGVELFAADLLVVSAECIMWVVHSGFLLTARQYGELSHRGSLLINVVWL 146
                 || :|:.:.|                                    |:|    |.||.:.
Yeast    68 -----LP-SKINSRH------------------------------------LTH----LTNVCFQ 86

  Fly   147 TVVVLDAVWLRTSRHFSWWPWSL-ATLVCDLLF--GVTLIPKGSAVYSSLPRSG----------- 197
            :.:::..:.|.:......:|:.| ..|..:|||  |::|..:..|.:.|....|
Yeast    87 STLIICELALVSQSSDRVYPFILKKALYLNLLFNLGISLPTQYLAYFKSTFSMGNQLFYYMFQIL 151

  Fly   198 -----VSAREDEGLLSQRYT--------------------YFQFDL------NESHLGHAQD--- 228
                 :..|...|..::|.|                    .|.:||      ||....:.::
Yeast   152 LQLFLILQRYYHGSSNERLTVISGQTAMILEVLLLFNSVAIFIYDLCIFEPINELSEYYKKNGWY 216

  Fly   229 -EANLGSRFLFHWVQPLILKGVAGKLRKIEDLFDLP----DALNITRLSE--KLHLALSQ---SQ 283
             ..::.|...|.|:..||::....|  ||:|...||    | |||..:|:  |.:..|.:   ..
Yeast   217 PPVHVLSYITFIWMNKLIVETYRNK--KIKDPNQLPLPPVD-LNIKSISKEFKANWELEKWLNRN 278

  Fly   284 SLWRALHRCFGVEFYLIGILRLIADLSGFAGP----LLLGGLLRQDHA--DPNQVYYYALGLFGS 342
            |||||:.:.||....:..:....:||.....|    :.:.||..:..:  .|....:.||.||..
Yeast   279 SLWRAIWKSFGRTISVAMLYETTSDLLSVVQPQFLRIFIDGLNPETSSKYPPLNGVFIALTLFVI 343

  Fly   343 TLLSAVCATHFDWRMAMVSMKMRVGVVNSIYRKALE---ARGLKESKPDLLNLMSTDTDRIVNSC 404
            :::|......|...:....:.:|..:.:.:|:|:|.   |...::|..|:|||||.|..||....
Yeast   344 SVVSVFLTNQFYIGIFEAGLGIRGSLASLVYQKSLRLTLAERNEKSTGDILNLMSVDVLRIQRFF 408

  Fly   405 ISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLMTAKDARLS 469
            .:.......|.::...|..||..||.|.:.|::..|:::|||.:|::::...|...|..||.|:.
Yeast   409 ENAQTIIGAPIQIIVVLTSLYWLLGKAVIGGLVTMAIMMPINAFLSRKVKKLSKTQMKYKDMRIK 473

  Fly   470 ATTETMQGAKQIKINAWEDIFITKIRGLRQE-ELRFLSKRKYLDAMCVYFWATTPVLMCLLTFGV 533
            ..||.:...|.||:.|||:..:.::..:|.: ||:...|...:..:..:.|...|:::...|||:
Yeast   474 TITELLNAIKSIKLYAWEEPMMARLNHVRNDMELKNFRKIGIVSNLIYFAWNCVPLMVTCSTFGL 538

  Fly   534 -SVLMGNPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDVPNLDYSSYYNP 597
             |:...:||..:..:.|::|..:|...:.:.|.::|.:||..||::|::..:....:| .|:...
Yeast   539 FSLFSDSPLSPAIVFPSLSLFNILNSAIYSVPSMINTIIETSVSMERLKSFLLSDEID-DSFIER 602

  Fly   598 IMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDS---------------DEQT--SPTPFRMKD 645
            |           |...|......::|...:|...|               ||::  ..:...:|:
Yeast   603 I-----------DPSADERALPAIEMNNITFLWKSKEVLTSSQSGDNLRTDEESIIGSSQIALKN 656

  Fly   646 I-NVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDG-------EVCVQELTTGFGYVPQSPWL 702
            | :.:.|.|.|||:.|.||.|||:||.||:..|.|..|       ::.::  ::...|..|..|:
Yeast   657 IDHFEAKRGDLVCVVGRVGAGKSTFLKAILGQLPCMSGSRDSIPPKLIIR--SSSVAYCSQESWI 719

  Fly   703 QRGTIRDNIVWGAQFDEQWYKTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQRARVALARAV 766
            ...::|:||::|.:||:.:|...:.||.|..||:|| .||...|||.|.:|||||:||::|||||
Yeast   720 MNASVRENILFGHKFDQDYYDLTIKACQLLPDLKILPDGDETLVGEKGISLSGGQKARLSLARAV 784

  Fly   767 YQDKKVYLLDDVLSSLDAHVARHIIKHCIL---RLLKHKTRIVVTRNIQLFFHANQILQVKDGQL 828
            |....:|||||:||::||.|:::||::.::   .|||:||.|:.|..:.:..|:..|..:::|::
Yeast   785 YSRADIYLLDDILSAVDAEVSKNIIEYVLIGKTALLKNKTIILTTNTVSILKHSQMIYALENGEI 849

  Fly   829 -------------------------------------LPSEYMTQS-----IELSLDE-DADDEQ 850
                                                 :.:|:.::|     ::|.:.| :.:||
Yeast   850 VEQGNYEDVMNRKNNTSKLKKLLEEFDSPIDNGNESDVQTEHRSESEVDEPLQLKVTESETEDE- 913

  Fly   851 EPTVRRRSVELSNQYDKKS--------------LDSL----LLEELREYGHLSGNVFTCYWKAVT 897
              .|....:||.....:::              |||:    ...|..|.|.:...::..|.||..
Yeast   914 --VVTESELELIKANSRRASLATLRPRPFVGAQLDSVKKTAQKAEKTEVGRVKTKIYLAYIKACG 976

  Fly   898 SPLAFTVLLSVVLMQLTRNLSDA---WLAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGHTT 959
               ...|:|..:.|.|||....|   ||.||     .:.::.:.|.:.:.|
Yeast   977 ---VLGVVLFFLFMILTRVFDLAENFWLKYW-----SESNEKNGSNERVWM-------------- 1019

  Fly   960 KFYLSIFTAIAVSNSLVTLARA-FLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRF 1023
              ::.:::.|.|:::.....|: .:..|..|:.:..:||.:.|.|:.:...||:.|.||||:|||
Yeast  1020 --FVGVYSLIGVASAAFNNLRSIMMLLYCSIRGSKKLHESMAKSVIRSPMTFFETTPVGRIINRF 1082

  Fly  1024 SSDTNTVDDSLPFILNILLAQ-LAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDI 1087
            |||.:.||.:|.:|.:..... |..||..:.|. |.|||..:..:.:|.||:..|..|...||::
Yeast  1083 SSDMDAVDSNLQYIFSFFFKSILTYLVTVILVG-YNMPWFLVFNMFLVVIYIYYQTFYIVLSREL 1146

  Fly  1088 KRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQL 1152
            |||.|.:.||:.:..:|:|.|.:.|.:.....||......|::.::.......:..:||::|||.
Yeast  1147 KRLISISYSPIMSLMSESLNGYSIIDAYDHFERFIYLNYEKIQYNVDFVFNFRSTNRWLSVRLQT 1211

  Fly  1153 LGTLLVGGAGLLAAIT--ASHTTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQY 1215
            :|..:|....:||..|  .....:.|:|||.:||:|.:||.|..::......|..:|:||||.:|
Yeast  1212 IGATIVLATAILALATMNTKRQLSSGMVGLLMSYSLEVTGSLTWIVRTTVTIETNIVSVERIVEY 1276

  Fly  1216 LQL-EEEQNASGSAEPPFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGAG 1279
            .:| .|.|:.:....|...||::|.:.|:.....|||:|.|.|..|..:.|..|::|||||||||
Yeast  1277 CELPPEAQSINPEKRPDENWPSKGGIEFKNYSTKYRENLDPVLNNINVKIEPCEKVGIVGRTGAG 1341

  Fly  1280 KTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDS 1344
            |:::..||.|:...|.|:|.:|.:::..:.|..||..:.:|.|:...|||||:.||||.:.:.:.
Yeast  1342 KSTLSLALFRILEPTEGKIIIDGIDISDIGLFDLRSHLAIIPQDAQAFEGTVKTNLDPFNRYSED 1406

  Fly  1345 EIWHAIKNSAAATLLVQQLGG-----------------LDGKVETCGNNLSAGQRQLLCLARALL 1392
            |:..|::.:.....|.:.|..                 ||.|:...|:|||.|||||||||||||
Yeast  1407 ELKRAVEQAHLKPHLEKMLHSKPRGDDSNEEDGNVNDILDVKINENGSNLSVGQRQLLCLARALL 1471

  Fly  1393 KNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGN 1457
            ..:|::.:||.|:::|.|:|..||..:|..||..|:|.||||:..:...|:|||||.|.:.|..:
Yeast  1472 NRSKILVLDEATASVDMETDKIIQDTIRREFKDRTILTIAHRIDTVLDSDKIIVLDQGSVREFDS 1536

  Fly  1458 PQSLASDSSTIFYGM 1472
            |..|.||.::|||.:
Yeast  1537 PSKLLSDKTSIFYSL 1551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	451/1638 (28%)
		ABC_membrane	328..560	CDD:294371	63/236 (27%)
		ABCC_MRP_domain1	621..827	CDD:213217	82/234 (35%)
		ABC_membrane	948..1192	CDD:279056	73/247 (30%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	92/236 (39%)
BPT1	NP_013086.1	MRP_assoc_pro	222..1556	CDD:188098	405/1375 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710