DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and ABCC6

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_187916.3	Gene:	ABCC6 / 820497	AraportID:	AT3G13090	Length:	1466	Species:	Arabidopsis thaliana

Alignment Length:	1556	Identity:	464/1556 - (29%)
Similarity:	717/1556 - (46%)	Gaps:	261/1556 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FAWN-WTQFCPTGLKPFANETNDLLPC---------FQEILLQLPVYTLFAAISAYNFGNQSRHV 64
            |::| ....|...|..|.:..: ||.|         |.::||   ....:.:||.|.||..:
plant    58 FSYNKLVLICCVSLSVFYSVLS-LLSCLHWHTNGWPFLDLLL---AALTWGSISVYLFGRYT--- 115

  Fly    65 VRNGLQLRMLSIRTFLAMVLALLPVAKVFAFHQQGVELFAADLLVVSAECIMWVVHSGFLLTARQ 129
              |..:.:          ||.||.|..||.|             |||  |...||  .|:|..:|
plant   116 --NSCEQK----------VLFLLRVWWVFFF-------------VVS--CYHLVV--DFVLYKKQ 151

  Fly   130 YGELSHRGSLLINVVWLTVVVLDAVWLRTSRHFSWWPWSLATLVCDLLFGVTLIPKGSAVYSSLP 194
                        .:|.:..|:.|.|.                 ||..||         ...|.|.
plant   152 ------------EMVSVHFVISDLVG-----------------VCAGLF---------LCCSCLW 178

  Fly   195 RSGVSARED---EGLLSQRYTYFQFDLNESHLGHAQDEANLGSRFLFHWVQPLILKGVAGKLRKI 256
            :.|...|.|   |.|||...:     .:...:.....:|.:.||..|.|:.|||..|    ..||
plant   179 KKGEGERIDLLKEPLLSSAES-----SDNEEVTAPFSKAGILSRMSFSWMSPLITLG----NEKI 234

  Fly   257 EDLFDLPDALNITRLSEKLHLALSQSQSLW-------------RALHRCFGVEFYLIGILRLIAD 308
            .|:.|:|. |:.:..:|.| ..:.:|:..|             :||......:..|..:|..:..
plant   235 IDIKDVPQ-LDRSDTTESL-FWIFRSKLEWDDGERRITTFKLIKALFLSVWRDIVLSALLAFVYT 297

  Fly   309 LSGFAGPLLLGGL---LRQDHADPNQVYYYALGLFGSTLLSAVCATHFDW--RMAMVSMKMRVGV 368
            :|.:..|.|:...   |..:....||.|......|.:.|:.  |.|...|  |.....:.||..:
plant   298 VSCYVAPYLMDNFVQYLNGNRQYKNQGYVLVTTFFVAKLVE--CQTQRQWFFRGQKAGLGMRSVL 360

  Fly   369 VNSIYRKAL-----EARGLKESKPDLLNLMSTDTDRIVNSCISFHFFWSIPFKLFTTLYLLYLQL 428
            |:.||.|.|     ..:|  .:..:::|||:.|.|||.......|..|.:..::...|::||..|
plant   361 VSMIYEKGLTLPCHSKQG--HTSGEIINLMAVDADRISAFSWFMHDPWILVLQVSLALWILYKSL 423

  Fly   429 GAAFLAGVIFAALLIPINRWLAKRIGIFSSGLMTAKDARLSATTETMQGAKQIKINAWEDIFITK 493
            |...:|......|::..|...||....|.|.||.:||.|:..|:|.:...|.:|:..||..|::|
plant   424 GLGSIAAFPATILVMLANYPFAKLEEKFQSSLMKSKDNRMKKTSEVLLNMKILKLQGWEMKFLSK 488

  Fly   494 IRGLRQEELRFLSKRKY-LDAMCVYFWATTPVLMCLLTFGVSVLMGNPLIASTTYTSVALLYMLI 557
            |..||..|..:|.|..| ..|:....|| .|..:....||..:|:..||.:.....::|...:|.
plant   489 ILELRHIEAGWLKKFVYNSSAINSVLWA-APSFISATAFGACLLLKIPLESGKILAALATFRILQ 552

  Fly   558 GPLNAFPWVLNGLIEAWVSIKRVQQLMDVPNLDYSSYYNPIMRGSGGSGAGDDAPLDAPKASVLQ 622
            ||:...|..::.:::..||:.|:...:.:.:|...      :.|...||:.:.|         ::
plant   553 GPIYKLPETISMIVQTKVSLNRIASFLCLDDLQQD------VVGRLPSGSSEMA---------VE 602

  Fly   623 MKCASFCHDSDEQTSPTPFRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDG--EVC 685
            :...:|..|   .:||.| .::|:|..:..|..|.|.|.||.||||.||:|:..:....|  :||
plant   603 ISNGTFSWD---DSSPIP-TLRDMNFKVSQGMNVAICGTVGSGKSSLLSSILGEVPKISGNLKVC 663

  Fly   686 VQELTTGFGYVPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLHACALEEDLQILG-GDLVGVGENG 749
            .::     .|:.||||:|.|.:.:||::|...:.:||..||.||:|.:||:||. .|...:||.|
plant   664 GRK-----AYIAQSPWIQSGKVEENILFGKPMEREWYDRVLEACSLNKDLEILPFHDQTVIGERG 723

  Fly   750 RTLSGGQRARVALARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCILRLLKHKTRIVVTRNIQLF 814
            ..|||||:.|:.:|||:|||..:||.||..|::|||...|:.|..:|.||:|||.|.||..::..
plant   724 INLSGGQKQRIQIARALYQDADIYLFDDPFSAVDAHTGSHLFKEVLLGLLRHKTVIYVTHQVEFL 788

  Fly   815 FHANQILQVKDGQLLPS-------EYMTQSIEL---------SLD--------EDADDEQEPTVR 855
            ..|:.||.:|||::..:       :..|..:||         ::|        |.:..::|..|.
plant   789 PEADLILVMKDGKITQAGKYHEILDSGTDFMELVGAHTEALATIDSCETGYASEKSTTDKENEVL 853

  Fly   856 RRSVELSNQYDKKSLDSLLLEELREYGHLSGNVFTCYWKAVTSPLAF------TVLLSVVLMQLT 914
            ....:..|..|.|....|:.||.||.|.:.   ||.|.|.:.  ||:      .:|:..||.||.
plant   854 HHKEKQENGSDNKPSGQLVQEEEREKGKVG---FTVYKKYMA--LAYGGAVIPLILVVQVLFQLL 913

  Fly   915 RNLSDAWLAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGHTTKFYLSIFTAIAVSNSLVTLA 979
            ...|:.|:. |||..:.|            :.|.|     ||.|   .:.::..:||::|...|.
plant   914 SIGSNYWMT-WVTPVSKD------------VEPPV-----SGFT---LILVYVLLAVASSFCILI 957

  Fly   980 RAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDSLP--------F 1036
            ||.|.|..|.|.|..:..::..::..|..:|||.|.:||||||.|:|.:..|..||        .
plant   958 RALLVAMTGFKMATELFTQMHLRIFRASMSFFDATPMGRILNRASTDQSVADLRLPGQFAYVAIA 1022

  Fly  1037 ILNILLAQLAGLVGALCVSLYAMPWLGLVI-IPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYT 1100
            .:|||     |::|.    :..:.|..|:: ||:|......:|.|..|:|::.||:..:.||:..
plant  1023 AINIL-----GIIGV----IVQVAWQVLIVFIPVVAACAWYRQYYISAARELARLAGISRSPVVH 1078

  Fly  1101 HFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLGTLLVGGAGLLA 1165
            ||:|||.|:|||||....|||:.|.....:...:.:...:.|.:||..||:||.|.....:.::.
plant  1079 HFSETLSGITTIRSFDQEPRFRGDIMRLSDCYSRLKFHSTGAMEWLCFRLELLSTFAFASSLVIL 1143

  Fly  1166 AITASHTTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQYLQLEEEQNASGSAEP 1230
            ........||.|.||.|:|||::......|:..:.:.|.::::|||:.||..:        .:||
plant  1144 VSAPEGVINPSLAGLAITYALNLNTLQATLIWTLCDLENKMISVERMLQYTNI--------PSEP 1200

  Fly  1231 PF---------GWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAA 1286
            |.         .||::|.::...:|:.|..||...|.|:|.......:.|||||||.||::::..
plant  1201 PLVIETTRPEKSWPSRGEITICNLQVRYGPHLPMVLHGLTCTFPGGLKTGIVGRTGCGKSTLIQT 1265

  Fly  1287 LLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIK 1351
            |.|:.....||||:|.:|:.::.|..||.|:.:|.|:|.:||||:|.||||...:.|.:||.|:.
plant  1266 LFRIVEPAAGEIRIDGINILSIGLHDLRSRLSIIPQDPTMFEGTIRSNLDPLEEYTDDQIWEALD 1330

  Fly  1352 NSAAATLLVQQLGG--------LDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLD 1408
            |.        |||.        ||..|...|.|.|.|||||:||.|.|||.:|::.:||.|:::|
plant  1331 NC--------QLGDEVRKKELKLDSPVSENGQNWSVGQRQLVCLGRVLLKRSKLLVLDEATASID 1387

  Fly  1409 DESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIF 1469
            ..:|..||:.||:.|..||::.||||:..:...|.:::||.|.|.|..:|..|..|.|::|
plant  1388 TATDNLIQETLRHHFADCTVITIAHRISSVIDSDMVLLLDQGLIKEHDSPARLLEDRSSLF 1448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	464/1556 (30%)
		ABC_membrane	328..560	CDD:294371	70/239 (29%)
		ABCC_MRP_domain1	621..827	CDD:213217	84/208 (40%)
		ABC_membrane	948..1192	CDD:279056	81/252 (32%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	89/227 (39%)
ABCC6	NP_187916.3	PLN03232	67..1452	CDD:215640	462/1547 (30%)
		ABC_membrane	286..555	CDD:294371	76/273 (28%)
		ABCC_MRP_domain1	601..801	CDD:213217	84/208 (40%)
		ABC_membrane	902..1173	CDD:294371	93/300 (31%)
		ABCC_MRP_domain2	1217..1437	CDD:213211	89/227 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53842
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730