DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and ABCC3

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_187915.1	Gene:	ABCC3 / 820496	AraportID:	AT3G13080	Length:	1514	Species:	Arabidopsis thaliana

Alignment Length:	1580	Identity:	464/1580 - (29%)
Similarity:	743/1580 - (47%)	Gaps:	238/1580 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LLPCFQEILLQLPVYTLFAAISAYNFGNQSRHVVRNGLQLRMLS--IRTFLAMVLALLPVAKV-- 92
            :|..|.|.:|.|                .||..:...|.||.||  :.:.|.:||....|.|.
plant    15 MLFSFSESILPL----------------DSRSFLLKPLFLRWLSGFLHSVLLLVLFFSWVRKKIR 63

  Fly    93 --------------FAFHQQ---GVELFAADLLVVSAECIMW-----------VVHSGFLLTARQ 129
                          |.|...   .:.|...:|:::|.....|           |...||||....
plant    64 GDSGVTESLKDRRDFGFKSALFCSLALSLLNLVLMSLSGFYWYESGWLDNEQLVSSLGFLLGMVS 128

  Fly   130 YGELS----------HRGSLLINVVWLTV--------VVLDAVWLRTSRHFSWWPWSLATLVCDL 176
            :|.||          |:.:..:..:||..        :|:|.|........   |..|  ||.|:
plant   129 WGVLSICLHRCRDCEHKKAPFLLRLWLVFYLVVSCYSLVVDFVMYERRETV---PVHL--LVFDI 188

  Fly   177 LFGVTLIPKGSAVYSSLPRSGVSAREDEGLLSQRYTYF----QFDLNESH-LGHAQDEANLG--S 234
            :..:..:..|........||..:...:|.||:...:..    ..:||::: .|.|...:..|  |
plant   189 VAFIAAVFLGYVAVLKKDRSNSNGVLEEPLLNGGDSRVGGDDSVELNKTNGSGEATPYSRAGILS 253

  Fly   235 RFLFHWVQPLILKGVAGKLRKIEDLFDLPDALNITRLSEKLHLALSQSQ----------SLWRAL 289
            ...|.|:.|||..| ..|...:||:..|.|..::..|:.|....|....          .|.:||
plant   254 LLTFSWMSPLIDIG-NKKTLDLEDVPQLHDTDSVVGLAPKFRSMLESPDGGERSGVTTFKLIKAL 317

  Fly   290 HRCFGVEFYLIGILRLIADLSGFAGPLL-------LGGLLRQDHADPNQVYYYALGLFGSTLLSA 347
            :.....|..:......|..::.:.||.|       |.|..:.:|    :.|...:..|.:.::..
plant   318 YFTAQWEILVTAFFAFIYTVASYVGPALIDTFVQYLNGRRQYNH----EGYVLVITFFAAKIVEC 378

  Fly   348 VCATHFDWRMAMVSMKMRVGVVNSIYRKAL-----EARGLKESKPDLLNLMSTDTDRIVNSCISF 407
            :...|:.:|:..|.::||..:|..||.|.|     ..:|  .:..:::|.|:.|.:||.|.....
plant   379 LSQRHWFFRLQKVGIRMRSALVAMIYEKGLTLSCQSKQG--RTSGEIINFMTVDAERIGNFSWYM 441

  Fly   408 HFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLMTAKDARLSATT 472
            |..|.:..::...|::||..||.|.:|.::...:::.||....:....|...||.|||:|:.:|:
plant   442 HDPWMVLLQVGLALWILYRNLGLASIAALVATIIVMLINFPFGRMQERFQEKLMEAKDSRMKSTS 506

  Fly   473 ETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVY-FWATTPVLMCLLTFGVSVL 536
            |.::..:.:|:..||..|::||..||:.|..:|.|..|..|:..: ||. .|.|:.:.|||..:|
plant   507 EILRNMRILKLQGWEMKFLSKIFDLRKSEEGWLKKYVYNSAVISFVFWG-APTLVSVSTFGACIL 570

  Fly   537 MGNPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDVPNLDYSSYYNPIMRG 601
            :|.||.:....:::|...:|..|:...|..::.:::..||:.|:...:.:.||. ......:.:|
plant   571 LGIPLESGKILSALATFRILQEPIYNLPDTISMIVQTKVSLDRLASYLCLDNLQ-PDIVERLPKG 634

  Fly   602 SGGSGAGDDAPLDAPKASVLQMKCASFCHDSDEQTSPTPFRMKDINVDIKAGQLVCIEGPVGGGK 666
            |      .|..::... |.|....:|        ::||   :||||..:..|..|.:.|.||.||
plant   635 S------SDVAVEVIN-STLSWDVSS--------SNPT---LKDINFKVFPGMKVAVCGTVGSGK 681

  Fly   667 SSFLSAIVANLQCTDG--EVCVQELTTGFGYVPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLHAC 729
            ||.||:::..:....|  :||..:     .||.||||:|.|.|.|||::|...:.:.|..||.||
plant   682 SSLLSSLLGEVPKVSGSLKVCGTK-----AYVAQSPWIQSGKIEDNILFGKPMERERYDKVLEAC 741

  Fly   730 ALEEDLQILG-GDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLDAHVARHIIKH 793
            :|.:||:||. ||...:||.|..|||||:.|:.:|||:|||..:||.||..|::|||...|:.|.
plant   742 SLSKDLEILSFGDQTVIGERGINLSGGQKQRIQIARALYQDADIYLFDDPFSAVDAHTGSHLFKE 806

  Fly   794 CILRLLKHKTRIVVTRNIQLFFHANQILQVKDGQLLPS-EYM------TQSIEL----------- 840
            .:|.||..|:.|.||..::....|:.||.:|||::..: :|.      |..:||
plant   807 VLLGLLCSKSVIYVTHQVEFLPAADLILVMKDGRISQAGKYNDILNSGTDFMELIGAHQEALAVV 871

  Fly   841 -SLDEDADDE-----QEPTVRRRSVELSNQYDKKSLDS-----------LLLEELREYGHLSGNV 888
             |:|.::..|     ||..:.:.::.:..:.:.:.|.:           ::.||.||.|.::.:|
plant   872 DSVDANSVSEKSALGQENVIVKDAIAVDEKLESQDLKNDKLESVEPQRQIIQEEEREKGSVALDV 936

  Fly   889 FTCYWKAVTSPLAF------TVLLSVVLMQLTRNLSDAWLAYWVTETTLD---PHKNDTSLDHIL 944
               |||.:|  ||:      .:||..||.||.:..|:.|:| |.|..:.|   |.|..|
plant   937 ---YWKYIT--LAYGGALVPFILLGQVLFQLLQIGSNYWMA-WATPVSEDVQAPVKLST------ 989

  Fly   945 MRPTVGNETESGHTTKFYLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFN 1009
                             .:.::.|:|..:||..|.||.|...||.|.|..:..|:...:..:..:
plant   990 -----------------LMIVYVALAFGSSLCILLRATLLVTAGYKTATELFHKMHHCIFRSPMS 1037

  Fly  1010 FFDITSVGRILNRFSSDTNTVDDSLPF---ILNILLAQLAGLVGALCVSLYAMPWL-GLVIIPMV 1070
            |||.|..|||::|.|:|.:.||..||:   .:.|.:.||.|::|.:.    .:.|| .||.||:|
plant  1038 FFDSTPSGRIMSRASTDQSAVDLELPYQFGSVAITVIQLIGIIGVMS----QVSWLVFLVFIPVV 1098

  Fly  1071 PIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESI-K 1134
            ...:..|:.|..|:|::.||.....:||..||:||:.|.|||||.....||:.| .::|.:.. :
plant  1099 AASIWYQRYYIAAARELSRLVGVCKAPLIQHFSETISGATTIRSFSQEFRFRSD-NMRLSDGYSR 1162

  Fly  1135 AQLTQSAAQQWLALRLQLLGTL-LVGGAGLLAAITASHTTNPGLVGLCISYALSITGQLGDLLHA 1198
            .:...:.|.:||..||.:|.:| .|.....|.:|... ..:|.|.||.::|.||:......|:..
plant  1163 PKFYTAGAMEWLCFRLDMLSSLTFVFSLVFLVSIPTG-VIDPSLAGLAVTYGLSLNTLQAWLIWT 1226

  Fly  1199 VAETEQELVAVERIDQYLQLEEEQNASGSAEPPF---------GWPTQGVLSFREVQLSYREHLA 1254
            :...|.::::||||.||        ||..:|||.         .||::|.:..|::|:.|..|:.
plant  1227 LCNLENKIISVERILQY--------ASVPSEPPLVIESNRPEQSWPSRGEVEIRDLQVRYAPHMP 1283

  Fly  1255 PALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGV 1319
            ..|||||...:...|.|||||||:||::::..|.|:...:.||||:|.||:.|:.|..||.|:.:
plant  1284 LVLRGITCTFKGGLRTGIVGRTGSGKSTLIQTLFRIVEPSAGEIRIDGVNILTIGLHDLRLRLSI 1348

  Fly  1320 ITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQLGGLDGKVETCGNNLSAGQRQL 1384
            |.|:|.:||||:|.||||...:.|.:||.|:........:.::...||..|...|:|.|.|||||
plant  1349 IPQDPTMFEGTMRSNLDPLEEYTDDQIWEALDKCQLGDEVRKKEQKLDSSVSENGDNWSMGQRQL 1413

  Fly  1385 LCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDD 1449
            :||.|.|||.:|::.:||.|:::|..:|..||:.||..|..||::.||||:..:...|.:::|.:
plant  1414 VCLGRVLLKRSKILVLDEATASVDTATDNLIQKTLREHFSDCTVITIAHRISSVIDSDMVLLLSN 1478

  Fly  1450 GRICEEGNPQSLASDSSTIF 1469
            |.|.|...|..|..|.|:.|
plant  1479 GIIEEYDTPVRLLEDKSSSF 1498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	464/1580 (29%)
		ABC_membrane	328..560	CDD:294371	65/237 (27%)
		ABCC_MRP_domain1	621..827	CDD:213217	84/208 (40%)
		ABC_membrane	948..1192	CDD:279056	78/249 (31%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	89/219 (41%)
ABCC3	NP_187915.1	MRP_assoc_pro	115..1499	CDD:188098	441/1464 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53842
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730